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    Gene sequencing structure, gene sequencing device and gene sequencing method
    1.
    发明授权
    Gene sequencing structure, gene sequencing device and gene sequencing method 有权

    公开(公告)号：US12203131B2

    公开(公告)日：2025-01-21

    申请号：US17580176

    申请日：2022-01-20

    Applicant: Shanghai Tianma Micro-Electronics Co., Ltd.

    Inventor： Baiquan Lin ,  Kerui Xi ,  Kaidi Zhang ,  Wei Li ,  Yunfei Bai ,  Ping Su ,  Junting Ouyang

    IPC: C12Q1/00 ,  B01L3/00 ,  C12Q1/6825 ,  G01N27/414

    Abstract: A gene sequencing structure, a gene sequencing device and a gene sequencing method are provided. The gene sequencing structure includes a substrate, a thin-film transistor array layer located on the substrate and including thin-film transistors that include a first electrode, and a second electrode; an ion-sensitive layer located on a side of the semiconductor layer away from the substrate; a micro-hole layer located on a side of the ion-sensitive layer away from the substrate, including a through-hole passing through the micro-hole layer, at least partially overlapping the semiconductor layer, and used for receiving a to-be-tested single-stranded nucleic acid inside; a conductive structure, located on a side of the layer away from the substrate and electrically connected to the first electrode or the second electrode; and a detection chip, located on a side of the conductive structure away from the substrate and electrically connected to the conductive structure.

    Detection device and detection method
    2.
    发明授权
    Detection device and detection method 有权

    公开(公告)号：US12163914B2

    公开(公告)日：2024-12-10

    申请号：US17682979

    申请日：2022-02-28

    Applicant: Shanghai Tianma Micro-Electronics Co., Ltd.

    Inventor： Kaidi Zhang ,  Baiquan Lin ,  Huihui Jiang ,  Luning Yang ,  Wei Li ,  Yunfei Bai ,  Zhenyu Jia ,  Kerui Xi ,  Feng Qin

    IPC: G01N27/414 ,  G01N27/333 ,  H01L21/768

    Abstract: A detection device and a detection method are provided. The detection device includes at least one detection unit. The detection unit includes a first transistor, a second transistor, a third transistor and a fourth transistor that are electrically connected to each other, a gate is disposed above a channel of each of the first transistor, the second transistor, and the third transistor, and an ion-sensitive membrane is covered above a channel of the fourth transistor. The detection device also includes a first voltage signal terminal, a second voltage signal terminal, and a third voltage signal terminal. Further, the detection device includes a first power supply terminal, a first potential output terminal, a second potential output terminal, and a second power supply terminal.

    Driving circuit, driving method and microfluidic substrate
    3.
    发明授权
    Driving circuit, driving method and microfluidic substrate 有权

    公开(公告)号：US12226771B2

    公开(公告)日：2025-02-18

    申请号：US17455148

    申请日：2021-11-16

    Applicant: Shanghai Tianma Micro-Electronics Co., Ltd.

    Inventor： Kaidi Zhang ,  Baiquan Lin ,  Wei Li ,  Yunfei Bai ,  Kerui Xi ,  Feng Qin

    IPC: B01L3/00 ,  G02B26/00 ,  G09G3/34

    Abstract: A driving circuit, a driving method and a microfluidic substrate are provided. The driving circuit includes a first switching unit, a second switching unit, a reset unit, a first capacitor, and a second capacitor. In a first stage of a driving process of the driving circuit, the first switching unit is turned on, a first voltage signal is transmitted to a first node, the second switching unit is turned on, a second voltage signal is input to an output terminal of the driving circuit, and the driving circuit outputs an AC signal. In a second stage of the driving process, the first switching unit is turned off, the valid signal output by the second scan signal terminal controls the reset unit to be turned on, a third voltage signal is input to the output terminal of the driving circuit for reset, and the driving circuit outputs a DC signal.

    Microfluidic chip and fabrication method
    4.
    发明授权
    Microfluidic chip and fabrication method 有权

    公开(公告)号：US12134097B2

    公开(公告)日：2024-11-05

    申请号：US17684719

    申请日：2022-03-02

    Applicant: Shanghai Tianma Micro-Electronics Co., Ltd.

    Inventor： Wei Li ,  Baiquan Lin ,  Kaidi Zhang ,  Yunfei Bai ,  Ping Su ,  Kerui Xi ,  Zhenyu Jia

    IPC: B01L3/00 ,  B81B3/00 ,  B81C1/00

    Abstract: A microfluidic chip and a fabrication method of the microfluidic chip are provided. The microfluidic chip includes an array substrate, and a hydrophobic layer disposed on a side of the array substrate. The hydrophobic layer includes at least one through-hole, and a through-hole of the at least one through-hole penetrates through the hydrophobic layer along a direction perpendicular to a plane of the array substrate. The microfluidic chip also includes at least one hydrophilic structure. A hydrophilic structure of the at least one hydrophilic structure is disposed in the through-hole.

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