公开(公告)号：US20210317480A1

公开(公告)日：2021-10-14

申请号：US17272252

申请日：2019-08-29

Applicant: ShanghaiTech University

Inventor： Jia Liu ,  Biao Jiang ,  Peixiang Ma ,  Guang Yang

IPC: C12N15/90 ,  A61K38/46 ,  A61K38/16 ,  C12N7/00 ,  A61K38/50 ,  A61K31/7088

Abstract: Provided are amino acid sequences capable of binding to and inhibiting a Cas protein's ability to bind to a nucleic acid molecule, thereby inhibiting the Cas protein's function in genome editing. Such Cas protein inhibitors, which can be comprised of a major coat protein (G8P), an extracellular region of the G8P (G8PEX), or a biological equivalent, are useful in improving the specificity of Cas protein-based genome editing procedures.

公开(公告)号：US20220213176A1

公开(公告)日：2022-07-07

申请号：US17702710

申请日：2022-03-23

Applicant: ShanghaiTech University ,  ShOx Science Limited

Inventor： Peixiang Ma ,  Guang Yang ,  Richard A. Lerner ,  Min Qiang ,  Hou Wang

IPC: C07K16/10 ,  A61P31/14

Abstract: The present disclosure provides human antibodies and fragments thereof having binding specificity to the SARS-CoV-2 spike protein's receptor binding domain (RBD). The antibodies and fragments have strong affinity and potent neutralization ability against the SARS-CoV-2 virus and various mutant forms. Also provided are trimeric antibodies which have further enhanced neutralization capabilities. The antibodies and fragments thus may be used for preventing or treating SARS-CoV-2 viral infection or detecting the presence of the virus in a sample.

公开(公告)号：US11492645B2

公开(公告)日：2022-11-08

申请号：US17272252

申请日：2019-08-29

Applicant: ShanghaiTech University

Inventor： Jia Liu ,  Biao Jiang ,  Peixiang Ma ,  Guang Yang

IPC: C12N15/63 ,  A61K31/70 ,  C12N15/90 ,  A61K31/7088 ,  A61K38/16 ,  A61K38/46 ,  A61K38/50 ,  C12N7/00 ,  A01K67/00

Abstract: Provided are amino acid sequences capable of binding to and inhibiting a Cas protein's ability to bind to a nucleic acid molecule, thereby inhibiting the Cas protein's function in genome editing. Such Cas protein inhibitors, which can be comprised of a major coat protein (G8P), an extracellular region of the G8P (G8PEX), or a biological equivalent, are useful in improving the specificity of Cas protein-based genome editing procedures.