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公开(公告)号：US08404809B2
公开(公告)日：2013-03-26
申请号：US12605028
申请日：2009-10-23
IPC分类号： C07K14/435
CPC分类号： A61K38/4846 , A61K47/549 , A61K47/60 , C12N9/644 , C12Y304/21022
摘要： Conjugates between Factor IX and PEG moieties are disclosed in the present application. The conjugates are linked via a glycosyl linking group interposed between and covalently attached to the peptide and the modifying group. Conjugates are formed from glycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto a glycosyl residue on the peptide. Also provided are methods for preparing the conjugates, methods for treating various disease conditions with the conjugates, and pharmaceutical formulations including the conjugates.
摘要翻译： 在本申请中公开了因子IX和PEG部分之间的缀合物。 缀合物通过插入在肽和修饰基团之间并共价连接到肽上的糖基连接基团连接。 通过糖基转移酶的作用由糖基化肽形成缀合物。 糖基转移酶将修饰的糖部分连接到肽上的糖基残基上。 还提供了制备缀合物的方法，用缀合物治疗各种疾病状况的方法，以及包括缀合物的药物制剂。
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公开(公告)号：US08063015B2
公开(公告)日：2011-11-22
申请号：US12496595
申请日：2009-07-01
申请人： Shawn DeFrees , David A. Zopf , Robert J. Bayer , David James Hakes , Caryn L. Bowe , Xi Chen
发明人： Shawn DeFrees , David A. Zopf , Robert J. Bayer , David James Hakes , Caryn L. Bowe , Xi Chen
IPC分类号： A01N37/18
CPC分类号： A61K47/48215 , A61K38/1793 , A61K38/1816 , A61K38/185 , A61K38/193 , A61K38/212 , A61K38/215 , A61K38/24 , A61K38/36 , A61K38/40 , A61K38/465 , A61K38/47 , A61K38/482 , A61K38/4846 , A61K38/57 , A61K39/3955 , A61K47/549 , A61K47/60 , C07K5/1013 , C07K5/1016 , C07K9/00 , C07K9/008 , C07K14/00 , C07K16/241 , C07K2317/24 , C12N9/6424 , C12N9/6437 , C12N9/644 , C12N9/6459 , C12N9/96 , C12P21/005 , C12Y301/27005 , C12Y302/01045 , C12Y304/21021 , C12Y304/21022 , C12Y304/21068
摘要： The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
摘要翻译： 本发明包括用于重组肽分子的方法和组合物，包括向肽添加或缺失一个或多个糖基，和/或向肽中加入修饰基团。
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