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    Preparation of microparticles having a selected release profile
    1.
    发明授权
    Preparation of microparticles having a selected release profile 有权
    具有选择的释放曲线的微粒的制备

    公开(公告)号：US06194006B1

    公开(公告)日：2001-02-27

    申请号：US09223276

    申请日：1998-12-30

    申请人： Shawn L. Lyons ,  J. Michael Ramstack ,  Steven G. Wright

    发明人： Shawn L. Lyons ,  J. Michael Ramstack ,  Steven G. Wright

    IPC分类号： A61K914

    CPC分类号： A61K9/1647 ,  A61K9/1694 ,  B01J13/02 ,  Y10T428/2982

    摘要： An improved method for preparing microparticles that exhibit controlled release of an effective amount of an active agent over an extended period of time. More particularly, a method is provided for preparing microparticles having a selected release profile for release of active agent contained in the microparticles. By adjusting the degree of drying that is performed during the preparation of the microparticles, the release profile can be controlled. By performing no intermediate drying, an initial burst and a substantially linear release profile is achieved. By performing substantially complete intermediate drying, an initial lag phase and a substantially sigmoidal release profile is achieved.

    摘要翻译： 一种用于制备在长时间内显示有效量的活性剂的受控释放的微粒的改进方法。 更具体地，提供了一种制备具有选择的释放曲线的微粒以释放微粒中所含的活性剂的方法。 通过调节在制备微粒期间进行的干燥程度，可以控制剥离曲线。 通过不进行中间干燥，实现初始脉冲串和基本上线性的释放曲线。 通过进行基本上完全的中间干燥，实现了初始滞后期和基本上S形释放曲线。

    Apparatus and method for preparing microparticles
    2.
    发明授权
    Apparatus and method for preparing microparticles 有权
    微粒制备装置及方法

    公开(公告)号：US06861016B2

    公开(公告)日：2005-03-01

    申请号：US10713039

    申请日：2003-11-17

    申请人： Shawn L. Lyons ,  Steven G. Wright

    发明人： Shawn L. Lyons ,  Steven G. Wright

    IPC分类号： A61J3/00 ,  A61K9/16 ,  A61K9/58 ,  A61K31/517 ,  A61K47/34 ,  A61P25/18 ,  B01J13/02

    CPC分类号： A61K9/1694 ,  A61K9/1682 ,  Y10T428/2985

    摘要： Apparatus and method for preparing microparticles. An emulsion is formed by combining two phases in a static mixing assembly. The static mixing assembly preferably includes a preblending static mixer and a manifold. The emulsion flows out of the static mixing assembly into a quench liquid whereby droplets of the emulsion form microparticles. The residence time of the emulsion in the static mixing assembly is controlled to obtain a predetermined particle size distribution of the resulting microparticles.

    摘要翻译： 微粒制备装置及方法。 通过在静态混合组件中组合两相形成乳液。 静态混合组件优选地包括预混合静态混合器和歧管。 乳液从静态混合组件流出到骤冷液体中，由此乳液的液滴形成微粒。 控制乳液在静态混合组件中的停留时间，以获得所得微粒的预定粒度分布。

    Apparatus for preparing microparticles using in-line solvent extraction
    4.
    发明授权
    Apparatus for preparing microparticles using in-line solvent extraction 有权
    使用在线溶剂萃取制备微粒的装置

    公开(公告)号：US06540393B1

    公开(公告)日：2003-04-01

    申请号：US09930450

    申请日：2001-08-16

    申请人： Shawn L. Lyons ,  Steven G. Wright

    发明人： Shawn L. Lyons ,  Steven G. Wright

    IPC分类号： B01F1502

    CPC分类号： A61K9/1694 ,  A61K9/1682 ,  Y10T428/2985

    摘要： Apparatus and method for preparing microparticles using in-line solvent extraction. An emulsion is formed by combining two phases in a static mixer. The emulsion is combined with an extraction liquid in a blending static mixer. The outflow of the blending static mixer is combined with additional extraction liquid. The additional extraction liquid and the outflow of the blending static mixer can be combined in a vessel, or through the use of a static mixer manifold that includes a plurality of static mixers.

    摘要翻译： 使用在线溶剂萃取制备微粒的装置和方法。 通过在静态混合器中组合两相来形成乳液。 将乳液与混合静态混合器中的提取液组合。 混合静态混合器的流出与另外的萃取液组合。 附加的提取液和混合静态混合器的流出可以组合在容器中，或者通过使用包括多个静态混合器的静态混合器歧管。

    Apparatus and method for preparing microparticles
    5.
    发明授权
    Apparatus and method for preparing microparticles 有权

    公开(公告)号：US06537586B2

    公开(公告)日：2003-03-25

    申请号：US10109641

    申请日：2002-04-01

    申请人： Shawn L. Lyons ,  Steven G. Wright

    发明人： Shawn L. Lyons ,  Steven G. Wright

    IPC分类号： A61K950

    CPC分类号： A61K9/1694 ,  A61K9/1682 ,  Y10T428/2985

    摘要： Apparatus and method for preparing microparticles. An emulsion is formed by combining two phases in a static mixing assembly. The static mixing assembly preferably includes a preblending static mixer and a manifold. The emulsion flows out of the static mixing assembly into a quench liquid whereby droplets of the emulsion form microparticles. The residence time of the emulsion in the static mixing assembly is controlled to obtain a predetermined particle size distribution of the resulting microparticles.

    Apparatus and method for preparing microparticles
    6.
    发明授权
    Apparatus and method for preparing microparticles 有权
    微粒制备装置及方法

    公开(公告)号：US06331317B1

    公开(公告)日：2001-12-18

    申请号：US09438659

    申请日：1999-11-12

    申请人： Shawn L. Lyons ,  Steven G. Wright

    发明人： Shawn L. Lyons ,  Steven G. Wright

    IPC分类号： A61K950

    CPC分类号： A61K9/1694 ,  A61K9/1682 ,  Y10T428/2985

    摘要： Apparatus and method for preparing microparticles. An emulsion is formed by combining two phases in a static mixing assembly. The static mixing assembly preferably includes a preblending static mixer and a manifold. The emulsion flows out of the static mixing assembly into a quench liquid whereby droplets of the emulsion form microparticles. The residence time of the emulsion in the static mixing assembly is controlled to obtain a predetermined particle size distribution of the resulting microparticles.

    摘要翻译： 微粒制备装置及方法。 通过在静态混合组件中组合两相形成乳液。 静态混合组件优选地包括预混合静态混合器和歧管。 乳液从静态混合组件流出到骤冷液体中，由此乳液的液滴形成微粒。 控制乳液在静态混合组件中的停留时间以获得所得微粒的预定粒度分布。