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公开(公告)号：US20180303825A1
公开(公告)日：2018-10-25
申请号：US15961201
申请日：2018-04-24
发明人： Harry G. Brittain , David A. Dickason , Joyce M. Hotz , Shawn L. Lyons , J. Michael Ramstack , Steven G. Wright
IPC分类号： A61K31/485 , C07C19/03 , C07D489/08 , C07D489/06
CPC分类号： A61K31/485 , C07B2200/13 , C07C19/03 , C07D489/06 , C07D489/08
摘要： This invention relates to the discovery of novel polymorphic forms of naltrexone, including solvates, hydrates, anhydrous and other crystalline forms and combinations thereof. These novel forms of naltrexone impart advantages in pharmaceutical formulations incorporating them, including sustained release, or long acting, formulations.
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公开(公告)号：US20180022023A1
公开(公告)日：2018-01-25
申请号：US15654094
申请日：2017-07-19
发明人： DANIEL THERRIAULT , KAMBIZ CHIZARI
IPC分类号： B29C64/153 , C08J3/075 , C07C307/08 , C07C31/02 , C08B37/08 , C07C19/03
CPC分类号： B29C64/153 , B29C64/106 , B29K2995/0005 , B33Y10/00 , B33Y70/00 , C07C19/03 , C07C31/02 , C07C307/08 , C08B37/003 , C08J3/075 , C09D5/24 , C09D7/61 , C09D7/70 , C09D105/08 , C08K3/041 , C08L5/08
摘要： An ink for solvent-cast 3D printing is provided. The ink comprises a solution or gel of a polymer in a volatile solvent, and carbon nanotubes dispersed in the solution or gel. In the ink, the carbon nanotubes are present in a carbon nanotubes:polymer weight ratio between about 20:80 and about 40:60, and the polymer and carbon nanotubes total concentration is between about 20 and about 35 wt %, based on the total weight of the ink. There is also provided a 3D printer ink cartridge comprising the ink; a method of manufacturing the ink; a method of manufacturing a solvent-cast 3D printed material using the ink, a solvent-cast 3D printed material as well as uses thereof.
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公开(公告)号：US20170369512A1
公开(公告)日：2017-12-28
申请号：US15537378
申请日：2015-12-09
发明人： Ulfried Felfer , Clemens Stueckler , Stefan Steinhofer , Andreas Pelz , Marcus Hanacek , Thomas Heinrich Pabst , George Winkler , Peter Poechlauer , Bas Ritzen , Michel Goldbach
IPC分类号： C07F5/02 , C07C19/03 , C07D307/06 , C07F1/02
CPC分类号： C07F5/025 , C07C19/03 , C07D307/06 , C07F1/02
摘要： A process for a continuous production of a boronic acid derivative based on a Matteson boronic ester homologation and an apparatus of performing the process are disclosed.
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公开(公告)号：US09365580B2
公开(公告)日：2016-06-14
申请号：US14945607
申请日：2015-11-19
发明人： Harry G. Brittain , David A. Dickason , Joyce M. Hotz , Shawn L. Lyons , J. Michael Ramstack , Steven G. Wright
IPC分类号： A61K31/485 , C07D489/08 , C07C19/03
CPC分类号： A61K31/485 , C07B2200/13 , C07C19/03 , C07D489/06 , C07D489/08
摘要： This invention relates to the discovery of novel polymorphic forms of naltrexone, including solvates, hydrates, anhydrous and other crystalline forms and combinations thereof These novel forms of naltrexone impart advantages in pharmaceutical formulations incorporating them, including sustained release, or long acting, formulations.
摘要翻译： 本发明涉及纳曲酮的新型多晶型物的发现，包括溶剂化物，水合物，无水和其它结晶形式及其组合。纳他酮的这些新型形式在掺入其中的药物制剂中赋予其优势，包括持续释放或长效制剂。
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公开(公告)号：US09302964B2
公开(公告)日：2016-04-05
申请号：US14749877
申请日：2015-06-25
发明人： Shoji Furuta , Tetsuo Otsuka
IPC分类号： C07C17/386 , C07C17/18 , C07C17/395
CPC分类号： C07C17/386 , C07C17/18 , C07C17/395 , C07C21/18 , C07C19/03
摘要： To provide a method for efficiently separating 2,3,3,3-tetrafluoropropene (HFO-1234yf) and chloromethane (R40) from a composition containing HFO-1234yf and R40. A method for separating HFO-1234yf containing substantially no R40, which comprises bringing an azeotropic composition or azeotrope-like composition of H FO-1234yf and R40 into contact with a specific extraction solvent.
摘要翻译： 提供从含有HFO-1234yf和R40的组合物有效分离2,3,3,3-四氟丙烯（HFO-1234yf）和氯甲烷（R40）的方法。 一种分离基本上不含R40的HFO-1234yf的方法，其包括使H FO-1234yf和R40的共沸组合物或类共沸组合物与特定的提取溶剂接触。
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公开(公告)号：US08859830B2
公开(公告)日：2014-10-14
申请号：US12717800
申请日：2010-03-04
申请人： John D. Myers
发明人： John D. Myers
CPC分类号： B01D53/1418 , B01D53/1406 , B01D53/1487 , B01D53/77 , B01D53/78 , B01D2252/10 , B01D2252/103 , B01D2252/2021 , B01D2252/504 , B01D2257/2045 , B01D2257/708 , B01D2257/80 , C07C17/16 , Y02P20/582 , C07C19/03
摘要： Methods and assemblies for improving the reaction kinetics of, conserving reactants utilized in, and/or producing a more pure reaction product of, liquid-phase reactions that involve volatile reactants and products are provided. The methods and assemblies herein provide for a feed of reaction liquid to two or more absorption zones, wherein the temperature and/or feed rate of the liquid is independently adjusted prior to introduction into at least one of the two or more absorption zones. More particularly, the temperature and feed rate of the liquid as delivered to each absorption zone can be adjusted independently to optimize the absorption of at least a portion of any gaseous reactants and byproducts from the gaseous product stream and/or to optimize reaction zone conditions. Reaction kinetics may thus be improved, or substantially maintained.
摘要翻译： 提供了用于改善用于和/或生产涉及挥发性反应物和产物的液相反应的更纯的反应产物的反应动力学的保护反应动力学的方法和装置。 本文的方法和组件提供了将反应液体进料到两个或更多个吸收区域，其中在引入两个或更多个吸收区域中的至少一个吸收区域之前，液体的温度和/或进料速率被独立地调节。 更具体地，可以独立地调节输送到每个吸收区域的液体的温度和进料速率，以优化来自气态产物流的至少一部分气态反应物和副产物的吸收和/或优化反应区条件。 反应动力学因此可以得到改善或基本维持。
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公开(公告)号：US20130253199A1
公开(公告)日：2013-09-26
申请号：US13690327
申请日：2012-11-30
申请人： ALKERMES, INC.
发明人： Harry G. Brittain , David A. Dickason , Joyce M. Hotz , Shawn L. Lyons , J. Michael Ramstack , Steven G. Wright
IPC分类号： C07D489/08 , C07C19/03
CPC分类号： A61K31/485 , C07B2200/13 , C07C19/03 , C07D489/06 , C07D489/08
摘要： This invention relates to the discovery of novel polymorphic forms of naltrexone, including solvates, hydrates, anhydrous and other crystalline forms and combinations thereof. These novel forms of naltrexone impart advantages in pharmaceutical formulations incorporating them, including sustained release, or long acting, formulations.
摘要翻译： 本发明涉及纳曲酮的新型多晶型物的发现，包括溶剂合物，水合物，无水和其它结晶形式及其组合。 纳曲酮的这些新型形式赋予其掺入它们的药物制剂中的优点，包括持续释放或长效制剂。
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公开(公告)号：US20110313214A1
公开(公告)日：2011-12-22
申请号：US13003426
申请日：2009-07-09
申请人： Jean-Luc Dubois
发明人： Jean-Luc Dubois
CPC分类号： C07C17/25 , C07C17/087 , C07C17/10 , C07C17/16 , C07C17/275 , C07C21/18 , C07C29/1518 , C07C41/09 , Y02E50/343 , C07C19/10 , C07C19/08 , C07C19/03 , C07C19/01 , C07C31/12 , C07C31/08 , C07C31/04 , C07C31/10 , C07C43/043
摘要： A subject of the invention is a compound of formula (I) XCFzR3-z in which: in which X represents a branched or linear unsaturated hydrocarbon radical having up to 5 carbon atoms, unsubstituted or substituted, R represents Cl, F, Br, I or H, Z is equal to 1, 2 or 3, and the bio-carbon content of which is at least 1%.A subject of the invention is also processes for the preparation of this compound.
摘要翻译： 本发明的主题是式（I）XCFzR 3-z的化合物，其中X表示具有至多5个碳原子的支链或直链不饱和烃基，未取代或取代的，R表示Cl，F，Br，I 或H，Z等于1,2或3，其生物碳含量为至少1％。 本发明的主题也是制备该化合物的方法。
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公开(公告)号：US20110311401A1
公开(公告)日：2011-12-22
申请号：US13220906
申请日：2011-08-30
申请人： John E. STAUFFER
发明人： John E. STAUFFER
IPC分类号： B01J19/00
CPC分类号： B01J8/0278 , B01J2208/00548 , C07C17/154 , C07C17/156 , C07C19/01 , C07C19/03 , C07C19/045
摘要： A reactor with swing feeds is provided for oxychlorination. This reactor comprises multiple inlets with controls capable of introducing feed streams sequentially to the reactor. In one configuration, a feed stream comprises a paraffin or olefin hydrocarbon such as methane or ethylene, and a second feed stream comprises oxygen and hydrogen chloride. By segregating these feeds, combustion reactions can be minimized and yields of chlorinated components increased.
摘要翻译： 提供具有摆动进料的反应器用于氧氯化。 该反应器包括具有能够将进料流顺序地引入反应器的对照物的多个入口。 在一种构型中，进料流包含石蜡或烯烃，例如甲烷或乙烯，第二进料流包含氧和氯化氢。 通过分离这些进料，燃烧反应可以最小化，并且氯化组分的产率增加。
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公开(公告)号：US20110257445A1
公开(公告)日：2011-10-20
申请号：US13089635
申请日：2011-04-19
CPC分类号： C07C17/383 , B01D3/141 , C07C19/03 , C07C19/041 , C07C19/04
摘要： The present invention relates to a process for separating chlorinated methanes utilizing a dividing wall column. Processes and manufacturing assemblies for generating chlorinated methanes are also provided, as are processes for producing products utilizing the chlorinated methanes produced and/or separated utilizing the present process(es) and/or assemblies.
摘要翻译： 本发明涉及利用分隔壁塔分离氯化甲烷的方法。 还提供了用于产生氯化甲烷的方法和制造组件，以及利用本方法和/或组件生产和/或分离的氯化甲烷生产产物的方法。
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