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    Mammalian pro-apoptotic Bok genes and their uses
    3.
    发明授权
    Mammalian pro-apoptotic Bok genes and their uses 失效
    哺乳动物促凋亡Bok基因及其用途

    公开(公告)号：US06376247B1

    公开(公告)日：2002-04-23

    申请号：US09518232

    申请日：2000-03-02

    申请人： Aaron J. W. Hsueh ,  Sheau Yu Hsu

    发明人： Aaron J. W. Hsueh ,  Sheau Yu Hsu

    IPC分类号： C12N1585

    CPC分类号： C07K14/4702 ,  A01K2217/075 ,  C07K14/4747

    摘要： Nucleic acid compositions encoding a pro-apoptotic protein, Bok (Bcl-2-related ovarian killer) are identified. Bok has conserved Bcl-2 homology domains 1, 2 and 3 and a C-terminal transmembrane region present in other Bcl-2 related proteins, but lacks the BH4 domain found only in anti-apoptotic Bcl-2 proteins. Over-expression of Bok induces apoptosis. Cell killing induced by Bok is suppressed by co-expression with selective anti-apoptotic Bcl-2 proteins. Bok is highly expressed in the ovary, testis and uterus, particularly in granulosa cells, the cell type that undergoes apoptosis during follicle atresia. Identification of Bok as a new pro-apoptotic protein with wide tissue distribution and hetero-dimerization properties facilitates elucidation of apoptosis mechanisms in reproductive and other tissues, and provides a means for manipulating apoptosis.

    摘要翻译： 鉴定了编码促凋亡蛋白Bok（Bcl-2相关卵巢杀伤剂）的核酸组合物。 Bok具有保守的Bcl-2同源结构域1,2和3以及存在于其他Bcl-2相关蛋白中的C末端跨膜区，但缺少仅在抗凋亡Bcl-2蛋白中发现的BH4结构域。 Bok的过度表达诱导凋亡。 通过与选择性抗凋亡Bcl-2蛋白的共表达抑制由Bok诱导的细胞杀伤。 Bok在卵巢，睾丸和子宫中高度表达，特别是在颗粒细胞中，卵泡闭锁期间细胞凋亡的细胞类型。 鉴定Bok作为具有广泛组织分布和异二聚性质的新的促凋亡蛋白促进了生殖细胞和其他组织中凋亡机制的阐明，并提供了一种操纵细胞凋亡的手段。

    Antibodies that bind stresscopin peptides
    4.
    发明授权
    Antibodies that bind stresscopin peptides 有权
    结合应激素肽的抗体

    公开(公告)号：US08481686B2

    公开(公告)日：2013-07-09

    申请号：US12896618

    申请日：2010-10-01

    申请人： Sheau Yu Hsu ,  Aaron J. W. Hsueh

    发明人： Sheau Yu Hsu ,  Aaron J. W. Hsueh

    IPC分类号： C07K16/18 ,  C07K17/00

    CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K14/57509 ,  G01N2500/02 ,  G01N2500/10

    摘要： The invention provides novel nucleic acids and polypeptides, referred to herein as stresscopin 1 and stresscopin 2, which preferentially activate the CRH-R2 receptor over the R1 receptor. Stresscopins, analogs and mimetics, and related CRH-R2 agonists suppress food intake and heat-induced edema; but do not induce substantial release of ACTH. Stresscopin also finds use in the recovery phase of stress responses, as an anti-inflammatory agent, as a hypotensive agent, as a cardioprotective agent, and in the treatment of psychiatric and anxiolytic disorders. Stresscopin nucleic acid compositions find use in identifying homologous or related proteins and the DNA sequences encoding such proteins; in producing compositions that modulate the expression or function of the protein; and in studying associated physiological pathways.

    摘要翻译： 本发明提供了新的核酸和多肽，在本文中称为应激素1和应激素2，其优先在R1受体上活化CRH-R2受体。 应激素，类似物和模拟物以及相关的CRH-R2激动剂抑制食物摄入和热诱导的水肿; 但不会引起ACTH的显着释放。 应激素还可用作应激反应的恢复期，作为抗炎剂，作为降压药，作为心脏保护剂，以及治疗精神病和抗焦虑障碍。 应激素核酸组合物用于鉴定同源或相关蛋白质和编码这些蛋白质的DNA序列; 在制备调节蛋白质的表达或功能的组合物中; 并研究相关的生理学途径。

    Mammalian pro-apoptotic Bok genes and their uses
    6.
    发明授权
    Mammalian pro-apoptotic Bok genes and their uses 失效

    公开(公告)号：US6043055A

    公开(公告)日：2000-03-28

    申请号：US186250

    申请日：1998-11-04

    申请人： Aaron J. W. Hsueh ,  Sheau Yu Hsu

    发明人： Aaron J. W. Hsueh ,  Sheau Yu Hsu

    IPC分类号： C07K14/47 ,  C12N1/15 ,  C12N15/12 ,  C12P21/02 ,  C12N5/10 ,  C12N15/63

    CPC分类号： C07K14/4702 ,  C07K14/4747 ,  A01K2217/075

    摘要： Nucleic acid compositions encoding a pro-apoptotic protein, Bok (Bcl-2-related ovarian killer) are identified. Bok has conserved Bcl-2 homology domains 1, 2 and 3 and a C-terminal transmembrane region present in other Bcl-2 related proteins, but lacks the BH4 domain found only in anti-apoptotic Bcl-2 proteins. Over-expression of Bok induces apoptosis. Cell killing induced by Bok is suppressed by co-expression with selective anti-apoptotic Bcl-2 proteins. Bok is highly expressed in the ovary, testis and uterus, particularly in granulosa cells, the cell type that undergoes apoptosis during follicle atresia. Identification of Bok as a new pro-apoptotic protein with wide tissue distribution and hetero-dimerization properties facilitates elucidation of apoptosis mechanisms in reproductive and other tissues, and provides a means for manipulating apoptosis.

    Gastric Inhibitory Peptide Variants and Their Uses
    7.
    发明申请
    Gastric Inhibitory Peptide Variants and Their Uses 审中-公开
    胃抑制肽变体及其用途

    公开(公告)号：US20120157379A1

    公开(公告)日：2012-06-21

    申请号：US13387931

    申请日：2010-07-29

    申请人： Sheau Yu Hsu

    发明人： Sheau Yu Hsu

    IPC分类号： A61K38/26 ,  A61P3/10 ,  C07K16/18 ,  C12Q1/68 ,  C07K14/47 ,  A61K38/16

    CPC分类号： C07K14/575 ,  A61K38/00

    摘要： Novel gastric inhibitory peptide (GIP) polypeptide compositions are provided. Human GIP alleles encode an extended peptide, referred to herein as GIP55S or GIP55G, which is resistant to serum degradation, relative to the known mature GIP peptide. GIP55S or GIP55G peptides find use where it is desirable to modulate insulin secretion.

    摘要翻译： 提供新的胃抑制肽（GIP）多肽组合物。 相对于已知的成熟GIP肽，人GIP等位基因编码延长的肽，本文称为GIP55S或GIP55G，其对血清降解具有抗性。 GIP55S或GIP55G肽可用于调节胰岛素分泌的地方。

    STRESSCOPINS AND THEIR USES
    8.
    发明申请
    STRESSCOPINS AND THEIR USES 有权
    压力及其用途

    公开(公告)号：US20080145927A1

    公开(公告)日：2008-06-19

    申请号：US11935350

    申请日：2007-11-05

    申请人： Sheau Yu Hsu ,  Aaron J.W. Hsueh

    发明人： Sheau Yu Hsu ,  Aaron J.W. Hsueh

    IPC分类号： C12N15/12 ,  C12N15/63

    CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K14/57509 ,  G01N2500/02 ,  G01N2500/10

    摘要： The invention provides novel nucleic acids and polypeptides, referred to herein as stresscopin 1 and stresscopin 2, which preferentially activate the CRH-R2 receptor over the R1 receptor. Stresscopins, analogs and mimetics, and related CRH-R2 agonists suppress food intake and heat-induced edema; but do not induce substantial release of ACTH. Stresscopin also finds use in the recovery phase of stress responses, as an anti-inflammatory agent, as a hypotensive agent, as a cardioprotective agent, and in the treatment of psychiatric and anxiolytic disorders. Stresscopin nucleic acid compositions find use in identifying homologous or related proteins and the DNA sequences encoding such proteins; in producing compositions that modulate the expression or function of the protein; and in studying associated physiological pathways.

    摘要翻译： 本发明提供了新的核酸和多肽，在本文中称为应激素1和应激素2，其优先在R1受体上活化CRH-R2受体。 应激素，类似物和模拟物以及相关的CRH-R2激动剂抑制食物摄入和热诱导的水肿; 但不会引起ACTH的显着释放。 应激素还可用作应激反应的恢复期，作为抗炎剂，作为降压药，作为心脏保护剂，以及治疗精神病和抗焦虑障碍。 应激素核酸组合物用于鉴定同源或相关蛋白质和编码这些蛋白质的DNA序列; 在制备调节蛋白质的表达或功能的组合物中; 并研究相关的生理学途径。

    Mammalian pro-apoptotic Bok genes and their uses
    9.
    发明授权
    Mammalian pro-apoptotic Bok genes and their uses 失效
    哺乳动物促凋亡Bok基因及其用途

    公开(公告)号：US06222017B1

    公开(公告)日：2001-04-24

    申请号：US09517347

    申请日：2000-03-02

    申请人： Aaron J. W. Hsueh ,  Sheau Yu Hsu

    发明人： Aaron J. W. Hsueh ,  Sheau Yu Hsu

    IPC分类号： C07K1447

    CPC分类号： C07K14/4702 ,  A01K2217/075 ,  C07K14/4747

    摘要： Nucleic acid compositions encoding a pro-apoptotic protein, Bok (Bcl-2-related ovarian killer) are identified. Bok has conserved Bcl-2 homology domains 1, 2 and 3 and a C-terminal transmembrane region present in other Bcl-2 related proteins, but lacks the BH4 domain found only in anti-apoptotic Bcl-2 proteins. Over-expression of Bok induces apoptosis. Cell killing induced by Bok is suppressed by co-expression with selective anti-apoptotic Bcl-2 proteins. Bok is highly expressed in the ovary, testis and uterus, particularly in granulosa cells, the cell type that undergoes apoptosis during follicle atresia. Identification of Bok as a new pro-apoptotic protein with wide tissue distribution and hetero-dimerization properties facilitates elucidation of apoptosis mechanisms in reproductive and other tissues, and provides a means for manipulating apoptosis.

    摘要翻译： 鉴定了编码促凋亡蛋白Bok（Bcl-2相关卵巢杀伤剂）的核酸组合物。 Bok具有保守的Bcl-2同源结构域1,2和3以及存在于其他Bcl-2相关蛋白中的C末端跨膜区，但缺少仅在抗凋亡Bcl-2蛋白中发现的BH4结构域。 Bok的过度表达诱导凋亡。 通过与选择性抗凋亡Bcl-2蛋白的共表达抑制由Bok诱导的细胞杀伤。 Bok在卵巢，睾丸和子宫中高度表达，特别是在颗粒细胞中，卵泡闭锁期间细胞凋亡的细胞类型。 鉴定Bok作为具有广泛组织分布和异二聚性质的新的促凋亡蛋白促进了生殖细胞和其他组织中凋亡机制的阐明，并提供了一种操纵细胞凋亡的手段。

    Stresscopins and their Uses
    10.
    发明申请
    Stresscopins and their Uses 有权
    应激素及其用途

    公开(公告)号：US20120066775A1

    公开(公告)日：2012-03-15

    申请号：US12896618

    申请日：2010-10-01

    申请人： Sheau Yu Hsu ,  Aaron J.W. Hsueh

    发明人： Sheau Yu Hsu ,  Aaron J.W. Hsueh

    IPC分类号： A01K67/00 ,  A61K38/17 ,  C07H21/04 ,  C12N15/63 ,  C12Q1/02 ,  A61P29/00 ,  A61P3/04 ,  A61P3/00 ,  A61P9/12 ,  A61P9/00 ,  A61P25/22 ,  C07K14/435 ,  G01N33/50

    CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K14/57509 ,  G01N2500/02 ,  G01N2500/10

    摘要： The invention provides novel nucleic acids and polypeptides, referred to herein as stresscopin 1 and stresscopin 2, which preferentially activate the CRH-R2 receptor over the R1 receptor. Stresscopins, analogs and mimetics, and related CRH-R2 agonists suppress food intake and heat-induced edema; but do not induce substantial release of ACTH. Stresscopin also finds use in the recovery phase of stress responses, as an anti-inflammatory agent, as a hypotensive agent, as a cardioprotective agent, and in the treatment of psychiatric and anxiolytic disorders. Stresscopin nucleic acid compositions find use in identifying homologous or related proteins and the DNA sequences encoding such proteins; in producing compositions that modulate the expression or function of the protein; and in studying associated physiological pathways.

    摘要翻译： 本发明提供了新的核酸和多肽，在本文中称为应激素1和应激素2，其优先在R1受体上活化CRH-R2受体。 应激素，类似物和模拟物以及相关的CRH-R2激动剂抑制食物摄入和热诱导的水肿; 但不会引起ACTH的显着释放。 应激素还可用作应激反应的恢复期，作为抗炎剂，作为降压药，作为心脏保护剂，以及治疗精神病和抗焦虑障碍。 应激素核酸组合物用于鉴定同源或相关蛋白质和编码这些蛋白质的DNA序列; 在制备调节蛋白质的表达或功能的组合物中; 并研究相关的生理学途径。