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9 条记录 (耗时 0.022 秒)

    Production and extraction of MicroRNA precursor as drug for cancer therapy
    1.
    发明授权
    Production and extraction of MicroRNA precursor as drug for cancer therapy 有权
    生产和提取微RNA前体作为癌症治疗药物

    公开(公告)号：US09399773B2

    公开(公告)日：2016-07-26

    申请号：US14142512

    申请日：2013-12-27

    申请人： Shi-Lung Lin ,  Donald Chang ,  David T S Wu

    发明人： Shi-Lung Lin ,  Donald Chang ,  David T S Wu

    IPC分类号： C12P19/34 ,  C12Q1/68 ,  C12N1/20 ,  C07H21/04 ,  C12N15/113 ,  C12N15/11

    CPC分类号： C12N15/113 ,  C12N15/111 ,  C12N2310/141 ,  C12N2330/50 ,  C12N2330/51

    摘要： This invention generally relates to a composition for developing novel anti-cancer drugs and/or vaccines and producing microRNA precursor (pre-miRNA) and/or its shRNA homologs/mimics/derivatives, and a method thereof. The present invention also relates to a use of a composition in producing novel prokaryote-produced microRNA precursor (pro-miRNA) capable of being delivered into human cells and processed by the cells into microRNA-like effectors to elicit specific silencing effects on certain targeted oncogenes, subsequently leading to a therapeutic result of tumor suppression and cancer therapy. Specifically, the method of the present invention includes inducing an expression of the pre-miRNA/pro-miRNAs, particularly human pre-miR-302, in prokaryotes through pol-2 or pol-2-like RNA promoter. Most importantly, the composition of the present invention is further a novel pre-miRNA-based drug that is capable of reprogramming the malignant properties of high-grade human liver cancers into a low-grade benign or even relatively normal stage—a mechanism called “Cancer Reversion”.

    摘要翻译： 本发明一般涉及用于开发新型抗癌药物和/或疫苗并产生微小RNA前体（pre-miRNA）和/或其shRNA同源物/模拟物/衍生物的组合物及其方法。 本发明还涉及一种组合物在生产新型原核生产的微小RNA前体（pro-miRNA）中的用途，其能够被递送到人类细胞中并被细胞加工成微小RNA样效应物以引发对某些靶向癌基因的特异性沉默效应 ，随后导致肿瘤抑制和癌症治疗的治疗结果。 具体地说，本发明的方法包括通过pol-2或pol-2样RNA启动子在原核生物中诱导前miRNA /前miRNAs，特别是人pre-miR-302的表达。 最重要的是，本发明的组合物还是一种新的基于前体miRNA的药物，其能够将高级别人类肝癌的恶性特征重新编程成低级良性或甚至相对正常的阶段 - 称为“ 癌症逆转“。

    In-vitro induction of adult stem cell expansion and derivation
    2.
    发明授权
    In-vitro induction of adult stem cell expansion and derivation 有权

    公开(公告)号：US11624067B2

    公开(公告)日：2023-04-11

    申请号：US16135723

    申请日：2018-09-19

    申请人： Shi-Lung Lin ,  Samantha Chang-Lin ,  Donald Chang

    发明人： Shi-Lung Lin ,  Samantha Chang-Lin ,  Donald Chang

    IPC分类号： C12N15/113 ,  C12N15/11 ,  C12P19/34 ,  C12N15/70

    摘要： This invention generally relates to a composition and its method of use for inducing adult stem cell (ASC) expansion and/or derivation in vitro, using miR-302-like pre-miRNAs, shRNAs and/or siRNAs, all of which contain a shared sequence of 5′-UAAGUGCUUC CAUGUUU-3′ (SEQ ID NO: 7) in the 5′-end, and further in conjunction with the use of some wound-healing-related defined factors, including but not limited to basic fibroblast growth factor (bFGF)/fibroblast growth factor 2 (FGF-2), leukemia inhibitory factor (LIF), insulin-like growth factor (IGF), Epidermal growth factor (EGF), platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), transforming growth factor (TGF), tumor necrosis factor (TNF), stem cell factor (SCF), homeobox proteins (HOX), Notch, GSK, Wnt/beta-Catenin signals, interleukins, and/or bone morphogenetic proteins (BMPs). The principle of the present invention is related to a novel mechanism of inducible symmetric ASC division recently found in a skin wound healing model in vivo. The resulting amplified ASCs are useful for treating a variety of human aging- and cell dysfunction-associated disorders, including but not limited to Alzheimer's disease, Parkinson's disease, motor neuron disease, stroke, diabetes, osteoporosis, myocardial infraction, hemophilia, anemia, AIDS, leukemia, lymphoma and many kinds of cancers as well as aging.

    Use of Novel Monosaccharide-like Glycylated Sugar Alcohol Compositions for Designing and Developing Anti-Diabetic Drugs
    4.
    发明申请
    Use of Novel Monosaccharide-like Glycylated Sugar Alcohol Compositions for Designing and Developing Anti-Diabetic Drugs 有权
    使用新型单糖样糖基化糖醇组合物设计和开发抗糖尿病药物

    公开(公告)号：US20150209377A1

    公开(公告)日：2015-07-30

    申请号：US14585978

    申请日：2014-12-30

    申请人： Shi-Lung Lin ,  Samantha Chang-Lin ,  Yi-Wen Lin ,  Donald Chang

    发明人： Shi-Lung Lin ,  Samantha Chang-Lin ,  Yi-Wen Lin ,  Donald Chang

    IPC分类号： A61K31/7012 ,  A61K31/221

    CPC分类号： A61K31/221 ,  A61K9/0053 ,  A61K9/08 ,  A61K31/7012 ,  A61K31/7024 ,  C12N15/111 ,  C12N15/113 ,  C12N2310/141 ,  C12N2320/32 ,  C12N2330/50 ,  C12N2330/51

    摘要： This invention is related to a novel sugar-like chemical composition and its use for diabetes therapy. Particularly, the present invention teaches the use of monosaccharide-like glycylated sugar alcohol compounds to block or reduce sugar absorption in diabetes patients, so as to prevent the risk of hyperglycemia symptoms. Glycylation of sugar alcohols is a totally novel reaction that has never been reported before. Therefore, the novelty of the present invention is that for the first time glycylated sugar alcohols not only was found but also was found to be useful for treating Diabetes mellitus. In addition, the present invention teaches a method for producing these glycylated sugar alcohols. In sum, the present invention includes not only a kind of novel sugar-like chemical compositions and its use for treating diabetes but also a state-of-the-art protocol and methodology for producing such a novel composition via glycylation of sugars and sugar alcohols.

    摘要翻译： 本发明涉及新型糖类化学组合物及其用于糖尿病治疗的用途。 特别地，本发明教导了使用单糖样的糖化糖醇化合物来阻止或减少糖尿病患者的糖吸收，以防止高血糖症状的风险。 糖醇的糖基化是一种完全新颖的反应，从未在之前报道过。 因此，本发明的新颖性不仅首次发现了糖化糖醇，而且被发现可用于治疗糖尿病。 此外，本发明教导了一种制备这些糖基化糖醇的方法。 总之，本发明不仅包括一种新型的糖类化学组合物及其用于治疗糖尿病的用途，而且还包括通过糖和糖醇的糖基化制备这种新型组合物的最新方案和方法 。

    Fixed wireless back haul for mobile communications using stratospheric platforms
    6.
    发明申请
    Fixed wireless back haul for mobile communications using stratospheric platforms 审中-公开
    使用平流层平台固定无线移动通信

    公开(公告)号：US20050032545A1

    公开(公告)日：2005-02-10

    申请号：US10931861

    申请日：2004-09-01

    申请人： Donald Chang ,  Ming Chang ,  Ying Feria ,  Harold Rosen

    发明人： Donald Chang ,  Ming Chang ,  Ying Feria ,  Harold Rosen

    IPC分类号： H04B7/185 ,  H04Q7/20

    CPC分类号： H04B7/18504

    摘要： A method and system for communicating includes a plurality of cells having base units therein. Each of the base units communicates with a plurality of users within the cells. A communications platform is located in a stratospheric location for transmitting and receiving information with respect to the base units. A gateway station communicates with the communications platform and routes signals to terrestrial networks or other user back through the communications platform. A microcell within at least one of the cells is used to provide coverage in a small geographic area such as within a building. Each of the microcells is also in communication with the gateway station through the platform.

    摘要翻译： 用于通信的方法和系统包括其中具有基本单元的多个单元。 每个基本单元与小区内的多个用户通信。 通信平台位于平流层位置，用于发送和接收关于基本单元的信息。 网关站与通信平台通信，并通过通信平台将信号路由到地面网络或其他用户。 至少一个小区内的微小区被用于在诸如建筑物内的小地理区域中提供覆盖。 每个微小区还通过平台与网关站通信。

    Dynamic cell CDMA code assignment system and method
    7.
    发明授权
    Dynamic cell CDMA code assignment system and method 有权
    动态小区CDMA码分配系统及方法

    公开(公告)号：US06891813B2

    公开(公告)日：2005-05-10

    申请号：US09735861

    申请日：2000-12-12

    申请人： Ying Feria ,  Ming Chang ,  Donald Chang

    发明人： Ying Feria ,  Ming Chang ,  Donald Chang

    IPC分类号： H04B7/204 ,  H04Q7/20

    CPC分类号： H04B7/2041

    摘要： A communications system and method of operating the communications system includes a high altitude communication device that communicates with a plurality of user terminals and a gateway station. The gateway station couples the users to terrestrial networks and other users. The high altitude communication device has a controller that assigns a first code to a beam of a first plurality of users. When one of the first plurality of users moves to interfere with one of the other of the first plurality of users, the beam associated with the user is reassigned another code.

    摘要翻译： 通信系统和操作通信系统的方法包括与多个用户终端和网关站通信的高空通信设备。 网关站将用户耦合到地面网络和其他用户。 高空通信设备具有将第一代码分配给第一多个用户的波束的控制器。 当第一多个用户中的一个移动以干扰第一多个用户中的另一个中的一个时，与用户相关联的波束被重新分配另一个码。