公开(公告)号：US07313260B2

公开(公告)日：2007-12-25

申请号：US11489371

申请日：2006-07-18

申请人： Shih-Ping Wang ,  Fangyi Rao

发明人： Shih-Ping Wang ,  Fangyi Rao

IPC分类号： G06K9/00

CPC分类号： A61B8/0825 ,  A61B6/463 ,  A61B6/502 ,  A61B6/5247 ,  A61B6/563 ,  A61B8/406 ,  A61B8/4281 ,  A61B8/4405 ,  A61B8/462 ,  A61B8/463 ,  A61B8/464 ,  A61B8/465 ,  A61B8/467 ,  A61B8/5238 ,  A61B8/565 ,  G06F19/00 ,  Y10S128/916

摘要： An adjunctive ultrasound mammography system and associated methods are described in which an ultrasound image being displayed near an x-ray mammogram image may be superimposed thereon or thereunder by a user for facilitating rapid comprehension of breast structures and detection of abnormalities therein. In one preferred embodiment, the x-ray mammogram image corresponds to a standard x-ray mammogram view, and the ultrasound image is a thick-slice image representing a thick-slice or slab-like portion of the breast volume substantially parallel to that standard x-ray mammogram view. In another preferred embodiment, the user is permitted to manually manipulate the registration of the ultrasound image with the x-ray mammogram image. It has been found that the manual registration process, which involves manual vernier adjustments responsive to perceived registration differences, can rapidly increase the radiologist's perception of the breast structures being displayed by both component images. Even though ultrasound images tend to have substantially different textures and feature emphases than x-ray images, the bimodal thick-slice/x-ray image, alone or in conjunction with the vernier registration process, can often expose or clarify tissue structures hidden in the separate component images, and can often obviate or explain certain noticed structures in the component images.

摘要翻译： 描述了一种辅助超声乳腺摄影系统及其相关方法，其中在X射线乳房X线照相图像附近显示的超声图像可以由用户叠加在其上或其上，以便于快速理解乳房结构并检测其中的异常。 在一个优选实施例中，X射线乳房X线照相图像对应于标准x射线乳房X线照片视图，超声图像是表示基本上平行于该标准的乳房体积的厚切片或板状部分的厚片图像 x射线乳房X线照片视图。 在另一个优选实施例中，允许用户用X射线乳腺X线照片图像手动地操作超声图像的登记。 已经发现，手动注册过程涉及响应于感知到的注册差异的手动游标调整，可以快速增加放射科医师对由两个分量图像显示的乳房结构的感知。 尽管超声图像倾向于具有与x射线图像相比具有显着不同的纹理和特征的重点，但双峰厚片/ X射线图像单独或与游标注册过程一起可以经常暴露或澄清隐藏在 单独的组件图像，并且经常可以避免或解释组件图像中的某些注意结构。

公开(公告)号：US07556602B2

公开(公告)日：2009-07-07

申请号：US10160836

申请日：2002-05-31

申请人： Shih-Ping Wang ,  Donald Chin ,  Fangyi Rao

发明人： Shih-Ping Wang ,  Donald Chin ,  Fangyi Rao

IPC分类号： A61B8/00

CPC分类号： A61B6/463 ,  A61B6/4423 ,  A61B6/502 ,  A61B6/5247 ,  A61B6/563 ,  A61B8/0825 ,  A61B8/406 ,  A61B8/462 ,  A61B8/463 ,  A61B8/464 ,  A61B8/465 ,  A61B8/467 ,  A61B8/469 ,  A61B8/5238 ,  A61B8/565 ,  G06F19/00

摘要： Ultrasound mammography in which an automated transducer scans the patient's breast to generate many images of thin slices that are processed into few images of thick slices that can be displayed simultaneously for practical rapid assessment of the breast. The thin-slice images can be acquired by a technician so that a physician need only spend time in assessing the few displayed thick-slice images and, possibly, only a few of the thin-slice images that might match a suspected anomaly indicated in the thick-slice images. Computer-aided detection or diagnosis (CAD) can be performed on the images and resulting mark and/or other information can be displayed as well. Vibration images can be obtained as well and similarly processed and displayed to highlight abnormalities or for other reasons.

摘要翻译： 超声乳腺摄影术，其中自动换能器扫描患者的乳房以产生薄片的许多图像，其被加工成可以同时显示以用于乳房的实际快速评估的厚片的少数图像。 薄片图像可以由技术人员获取，使得医生仅需要花费时间来评估少数显示的厚片图像，并且可能仅花费少量可能匹配疑似异常的薄片图像 厚片图像。 可以对图像执行计算机辅助检测或诊断（CAD），并且可以显示所得到的标记和/或其他信息。 也可以获得振动图像，并进行相似的处理和显示，以突显异常或其他原因。

公开(公告)号：US07103205B2

公开(公告)日：2006-09-05

申请号：US10305661

申请日：2002-11-27

申请人： Shih-Ping Wang ,  Fangyi Rao

发明人： Shih-Ping Wang ,  Fangyi Rao

IPC分类号： G06K9/00

CPC分类号： A61B8/0825 ,  A61B6/463 ,  A61B6/502 ,  A61B6/5247 ,  A61B6/563 ,  A61B8/406 ,  A61B8/4281 ,  A61B8/4405 ,  A61B8/462 ,  A61B8/463 ,  A61B8/464 ,  A61B8/465 ,  A61B8/467 ,  A61B8/5238 ,  A61B8/565 ,  G06F19/00 ,  Y10S128/916

摘要： An adjunctive ultrasound mammography system and associated methods are described in which an ultrasound image being displayed near an x-ray mammogram image may be superimposed thereon or thereunder by a user for facilitating rapid comprehension of breast structures and detection of abnormalities therein. In one preferred embodiment, the x-ray mammogram image corresponds to a standard x-ray mammogram view, and the ultrasound image is a thick-slice image representing a thick-slice or slab-like portion of the breast volume substantially parallel to that standard x-ray mammogram view. In another preferred embodiment, the user is permitted to manually manipulate the registration of the ultrasound image with the x-ray mammogram image. It has been found that the manual registration process, which involves manual vernier adjustments responsive to perceived registration differences, can rapidly increase the radiologist's perception of the breast structures being displayed by both component images. Even though ultrasound images tend to have substantially different textures and feature emphases than x-ray images, the bimodal thick-slice/x-ray image, alone or in conjunction with the vernier registration process, can often expose or clarify tissue structures hidden in the separate component images, and can often obviate or explain certain noticed structures in the component images.

摘要翻译： 描述了一种辅助超声乳腺摄影系统及其相关方法，其中在X射线乳房X线照相图像附近显示的超声图像可以由用户叠加在其上或其上，以便于快速理解乳房结构并检测其中的异常。 在一个优选实施例中，X射线乳房X线照相图像对应于标准x射线乳房X线照片视图，超声图像是表示基本上平行于该标准的乳房体积的厚切片或板状部分的厚片图像 x射线乳房X线照片视图。 在另一个优选实施例中，允许用户用X射线乳腺X线照片图像手动地操作超声图像的登记。 已经发现，手动注册过程涉及响应于感知到的注册差异的手动游标调整，可以快速增加放射科医师对由两个分量图像显示的乳房结构的感知。 尽管超声图像倾向于具有与x射线图像相比具有显着不同的纹理和特征的重点，但双峰厚片/ X射线图像单独或与游标注册过程一起可以经常暴露或澄清隐藏在 单独的组件图像，并且经常可以避免或解释组件图像中的某些注意结构。

公开(公告)号：US20090312640A1

公开(公告)日：2009-12-17

申请号：US12546339

申请日：2009-08-24

申请人： Shih-Ping Wang ,  Donald Chin ,  Fangyi Rao ,  Nico Karssemeijier

发明人： Shih-Ping Wang ,  Donald Chin ,  Fangyi Rao ,  Nico Karssemeijier

IPC分类号： A61B8/14 ,  G06K9/00 ,  A61B6/04

CPC分类号： A61B8/5215 ,  A61B6/463 ,  A61B6/502 ,  A61B6/5241 ,  A61B6/5247 ,  A61B6/563 ,  A61B8/0825 ,  A61B8/406 ,  A61B8/4281 ,  A61B8/4405 ,  A61B8/463 ,  A61B8/464 ,  A61B8/465 ,  A61B8/466 ,  A61B8/467 ,  A61B8/5238 ,  A61B8/565

摘要： An adjunctive ultrasound mammography system and associated methods are described comprising an adjunctive ultrasound display configured for quick, intuitive, interactive viewing of data derived from volumetric ultrasound scans, the data being displayed near a conventional x-ray mammogram display. Preferred embodiments for navigating among a thick-slice image array, a selected enlarged thick-slice image, and planar ultrasound views are described, including a preferred embodiment in which the planar ultrasound views are updated in real time as a cursor is moved across an active thick-slice image. In one preferred embodiment the thick-slice images are inverted prior to display, with non-breast areas of the image preferably segmented out and reset to dark. The inverted thick-slice images are of more familiar significance to radiologists having years of expertise in analyzing conventional x-ray mammograms. For example, the inverted thick-slice images allow benign features to be more easily dismissed as compared to non-inverted thick-slice images. Preferred embodiments for computing thick-slice image values from the volumetric scan data are also described that emphasize larger mass lesions in the resulting thick-slice images, and that compensate for mass lesions that straddle thick-slice region borders.

摘要翻译： 描述了一种辅助超声乳腺摄影系统和相关方法，其包括辅助性超声显示器，其配置用于快速，直观，互动地观看从体积超声扫描获得的数据，该数据显示在常规x射线乳房X线照片显示附近。 描述了用于在厚片图像阵列，选定的放大的厚片图像和平面超声波视图之间导航的优选实施例，包括优选实施例，其中当光标跨越活动的时候，平面超声波视图被实时地更新 厚片图像。 在一个优选实施例中，厚片图像在显示之前被反转，其中图像的非乳房区域优选地被分割出并且重新设置为暗。 倒置的厚片图像对于在分析常规x射线乳房X线照片方面具有多年专业知识的放射科医师更为重要。 例如，与非倒置厚片图像相比，反向厚片图像允许更容易地解除良性特征。 还描述了用于从体积扫描数据计算厚片图像值的优选实施例，其强调所得厚片图像中的较大质量损伤，并补偿跨越厚片区域边界的质量损伤。

公开(公告)号：US20060257009A1

公开(公告)日：2006-11-16

申请号：US11489371

申请日：2006-07-18

申请人： Shih-Ping Wang ,  Fangyi Rao

发明人： Shih-Ping Wang ,  Fangyi Rao

IPC分类号： G06K9/00

CPC分类号： A61B8/0825 ,  A61B6/463 ,  A61B6/502 ,  A61B6/5247 ,  A61B6/563 ,  A61B8/406 ,  A61B8/4281 ,  A61B8/4405 ,  A61B8/462 ,  A61B8/463 ,  A61B8/464 ,  A61B8/465 ,  A61B8/467 ,  A61B8/5238 ,  A61B8/565 ,  G06F19/00 ,  Y10S128/916

摘要： An adjunctive ultrasound mammography system and associated methods are described in which an ultrasound image being displayed near an x-ray mammogram image may be superimposed thereon or thereunder by a user for facilitating rapid comprehension of breast structures and detection of abnormalities therein. In one preferred embodiment, the x-ray mammogram image corresponds to a standard x-ray mammogram view, and the ultrasound image is a thick-slice image representing a thick-slice or slab-like portion of the breast volume substantially parallel to that standard x-ray mammogram view. In another preferred embodiment, the user is permitted to manually manipulate the registration of the ultrasound image with the x-ray mammogram image. It has been found that the manual registration process, which involves manual vernier adjustments responsive to perceived registration differences, can rapidly increase the radiologist's perception of the breast structures being displayed by both component images. Even though ultrasound images tend to have substantially different textures and feature emphases than x-ray images, the bimodal thick-slice/x-ray image, alone or in conjunction with the vernier registration process, can often expose or clarify tissue structures hidden in the separate component images, and can often obviate or explain certain noticed structures in the component images.

摘要翻译： 描述了一种辅助超声乳腺摄影系统及其相关方法，其中在X射线乳房X线照相图像附近显示的超声图像可以由用户叠加在其上或其上，以便于快速理解乳房结构并检测其中的异常。 在一个优选实施例中，X射线乳房X线照相图像对应于标准x射线乳房X线照片视图，超声图像是表示基本上平行于该标准的乳房体积的厚切片或板状部分的厚片图像 x射线乳房X线照片视图。 在另一个优选实施例中，允许用户用X射线乳腺X线照片图像手动地操作超声图像的登记。 已经发现，手动注册过程涉及响应于感知到的注册差异的手动游标调整，可以快速增加放射科医师对由两个分量图像显示的乳房结构的感知。 尽管超声图像倾向于具有与x射线图像相比具有显着不同的纹理和特征的重点，但双峰厚片/ X射线图像单独或与游标注册过程一起可以经常暴露或澄清隐藏在 单独的组件图像，并且经常可以避免或解释组件图像中的某些注意结构。

公开(公告)号：US07828732B2

公开(公告)日：2010-11-09

申请号：US12479468

申请日：2009-06-05

申请人： Shih-Ping Wang ,  Donald Chin ,  Fangyi Rao

发明人： Shih-Ping Wang ,  Donald Chin ,  Fangyi Rao

IPC分类号： A61B8/00

CPC分类号： A61B6/463 ,  A61B6/4423 ,  A61B6/502 ,  A61B6/5247 ,  A61B6/563 ,  A61B8/0825 ,  A61B8/406 ,  A61B8/462 ,  A61B8/463 ,  A61B8/464 ,  A61B8/465 ,  A61B8/467 ,  A61B8/469 ,  A61B8/5238 ,  A61B8/565 ,  G06F19/00

摘要： An adjunctive ultrasound mammography system and associated methods are described, comprising a scanning apparatus for facilitating standardized, repeatable breast ultrasound scans, and further comprising an adjunctive ultrasound display apparatus configured for fast, intuitive viewing of adjunctive ultrasound data concurrently with x-ray mammogram information. In one preferred embodiment, thick-slice ultrasound images are displayed near an x-ray mammogram such that a screening radiologist can quickly view the thick-slice images for assistance in interpreting the x-ray mammogram. Methods for concurrently acquiring and displaying vibrational resonance image (VDI) data are described. Computer-aided diagnosis (CAD) algorithms that incorporate acoustically-based feature vectors are described, the feature vectors including lateral shadow metrics, vertical shadow metrics, posterior enhancement metrics, and VDI-based metrics. Algorithms are also described that combine x-ray mammogram CAD results with adjunctive ultrasound CAD results without requiring complex image registrations therebetween. Many of the practical, economic, and political barriers to acceptance and integration of ultrasound mammography into existing mass breast cancer screening environments are mitigated.

摘要翻译： 描述了辅助超声乳腺摄影系统和相关方法，其包括用于促进标准化，可重复的乳房超声扫描的扫描装置，并且还包括辅助超声显示装置，其配置为与X射线乳腺X线照相信息同时快速，直观地观看辅助超声数据。 在一个优选实施例中，在x射线乳房X线照片附近显示厚片超声图像，使得筛选放射科医师可以快速查看厚切片图像以辅助解释X射线乳腺X线照片。 描述了同时获取和显示振动共振图像（VDI）数据的方法。 描述了包含声学特征向量的计算机辅助诊断（CAD）算法，其特征向量包括横向阴影度量，垂直阴影度量，后验增强度量和基于VDI的度量。 还描述了将x射线乳房X线照片CAD结果与辅助超声CAD结果相结合的算法，而不需要它们之间的复杂图像注册。 超声乳房X线照相术在现有的大规模乳腺癌筛查环境中接受和整合的许多实际，经济和政治障碍得到缓解。

公开(公告)号：US07597663B2

公开(公告)日：2009-10-06

申请号：US10305936

申请日：2002-11-27

申请人： Shih-Ping Wang ,  Donald Chin ,  Fangyi Rao ,  Nico Karssemeijier

发明人： Shih-Ping Wang ,  Donald Chin ,  Fangyi Rao ,  Nico Karssemeijier

IPC分类号： A61B8/00

CPC分类号： A61B8/5215 ,  A61B6/463 ,  A61B6/502 ,  A61B6/5241 ,  A61B6/5247 ,  A61B6/563 ,  A61B8/0825 ,  A61B8/406 ,  A61B8/4281 ,  A61B8/4405 ,  A61B8/463 ,  A61B8/464 ,  A61B8/465 ,  A61B8/466 ,  A61B8/467 ,  A61B8/5238 ,  A61B8/565 ,  G06F19/00

摘要： An adjunctive ultrasound mammography system and associated methods are described comprising an adjunctive ultrasound display configured for quick, intuitive, interactive viewing of data derived from volumetric ultrasound scans, the data being displayed near a conventional x-ray mammogram display. Preferred embodiments for navigating among a thick-slice image array, a selected enlarged thick-slice image, and planar ultrasound views are described, including a preferred embodiment in which the planar ultrasound views are updated in real time as a cursor is moved across an active thick-slice image. In one preferred embodiment the thick-slice images are inverted prior to display, with non-breast areas of the image preferably segmented out and reset to dark. The inverted thick-slice images are of more familiar significance to radiologists having years of expertise in analyzing conventional x-ray mammograms. For example, the inverted thick-slice images allow benign features to be more easily dismissed as compared to non-inverted thick-slice images. Preferred embodiments for computing thick-slice image values from the volumetric scan data are also described that emphasize larger mass lesions in the resulting thick-slice images, and that compensate for mass lesions that straddle thick-slice region borders.

摘要翻译： 描述了一种辅助超声乳腺摄影系统和相关方法，其包括辅助性超声显示器，其配置用于快速，直观，互动地观看从体积超声扫描获得的数据，该数据显示在常规x射线乳房X线照片显示附近。 描述了用于在厚片图像阵列，选定的放大的厚片图像和平面超声波视图之间导航的优选实施例，包括优选实施例，其中当光标移动到活动的时候，平面超声波视图被实时地更新 厚片图像。 在一个优选实施例中，厚片图像在显示之前被反转，其中图像的非乳房区域优选地被分割出并且重新设置为暗。 倒置的厚片图像对于在分析常规x射线乳房X线照片方面具有多年专业知识的放射科医师更为重要。 例如，与非倒置厚片图像相比，反向厚片图像允许更容易地解除良性特征。 还描述了用于从体积扫描数据计算厚片图像值的优选实施例，其强调所得厚片图像中的较大质量损伤，并补偿跨越厚片区域边界的质量损伤。

公开(公告)号：US20180256130A1

公开(公告)日：2018-09-13

申请号：US15975544

申请日：2018-05-09

申请人： Shih-Ping Wang

发明人： Shih-Ping Wang

IPC分类号： A61B8/08

CPC分类号： A61B8/0825 ,  A61B8/14 ,  A61B8/145 ,  A61B8/4209 ,  A61B8/4218 ,  A61B8/4281 ,  A61B8/4405 ,  A61B8/4455 ,  A61B8/4461 ,  A61B8/4494 ,  A61B8/463 ,  A61B8/483 ,  A61B8/54

摘要： A method and apparatus for acquisition of volumetric breast images for screening and/or diagnosing breast cancers using a rotary scanning template and transducer.

公开(公告)号：US08317702B2

公开(公告)日：2012-11-27

申请号：US10560200

申请日：2004-06-18

申请人： Zengpin Yu ,  Danhua Zhao ,  Thomas P. Neff ,  Wei Zhang ,  Shih-Ping Wang

发明人： Zengpin Yu ,  Danhua Zhao ,  Thomas P. Neff ,  Wei Zhang ,  Shih-Ping Wang

IPC分类号： A61B8/00

CPC分类号： A61B8/4477 ,  A61B8/0825 ,  A61B8/4281 ,  A61B8/4405 ,  A61B8/5238 ,  Y10T29/49005

摘要： A modular, flexible architecture for offering full-field breast ultrasound (FFBU) functionality and general-purpose ultrasound functionality in a single system is described. A conventional, general-purpose ultrasound system (202) is modified with an FFBU toolkit to create a dual-capability ultrasound system (200), the dual-capability ultrasound system (200) being able to accommodate both general-purpose ultrasound functionality and FFBU functionality, using a single ultrasound engine (112). Among other advantages, real-world clinical environments may enjoy cost savings for initial system procurement, space savings on clinic floors, easier and less expensive system upgrades, and the ability to use a single system and user interface for both FFBU screening and for follow-up diagnosis, biopsy, etc. Among other advantages from an ultrasound manufacturer's perspective are the ability to quickly and/or more easily come to market with an FFBU-related offering by modifying their existing general-purpose ultrasound systems (202) with FFBU toolkits to quickly create dual-capability ultrasound systems (200).

摘要翻译： 描述了在单个系统中提供全场乳房超声（FFBU）功能和通用超声功能的模块化，灵活的架构。 传统的通用超声系统（202）用FFBU工具包修改以创建双能力超声系统（200），双能力超声系统（200）能够容纳通用超声功能和FFBU 功能，使用单个超声引擎（112）。 除了其他优点之外，现实世界的临床环境可以节省初始系统采购成本，临床楼层节省空间，更便宜和更便宜的系统升级，以及使用单个系统和用户界面进行FFBU筛选和跟踪的功能， 诊断，活检等。超声波制造商的观点还有其他优点，即通过使用FFBU工具包修改现有的通用超声波系统（202），通过与FFBU相关的产品快速和/或更容易上市。 快速创建双功能超声系统（200）。

公开(公告)号：US20120089026A1

公开(公告)日：2012-04-12

申请号：US13296023

申请日：2011-11-14

申请人： Shih-Ping Wang ,  Jiayu Chen ,  Douglas G. Summers

发明人： Shih-Ping Wang ,  Jiayu Chen ,  Douglas G. Summers

IPC分类号： A61B8/14

CPC分类号： A61B8/0825 ,  A61B8/4218 ,  A61B8/4281 ,  A61B8/44 ,  A61B8/4405 ,  A61B8/4444 ,  A61B8/462 ,  A61B8/483 ,  A61B8/54

摘要： Apparatus and related methods for facilitating volumetric ultrasonic scanning of a breast are described. In one preferred embodiment, a generally cone-shaped radial scanning template having a vertex and a wide opening angle is provided, the radial scanning template having a slot-like opening extending outward from the vertex through which an ultrasound transducer scans the breast as the radial scanning template is rotated. In another preferred embodiment, a flexible membrane for compressing a skin surface of the breast is provided, the flexible membrane being mounted on a mechanical assembly such as a roller assembly to form a slot-like opening through which an ultrasound transducer directly contacts the skin surface, the flexible membrane rising and falling relative to the skin surface but not moving laterally as the slot-like opening and ultrasound transducer move laterally across the compressed breast, whereby stabilization of the breast and direct transducer-skin contact are concurrently achieved.

摘要翻译： 描述了用于促进乳房体积超声扫描的装置和相关方法。 在一个优选实施例中，提供了具有顶点和宽开口角度的大致锥形的径向扫描模板，该径向扫描模板具有从顶点向外延伸的狭缝状开口，超声波换能器通过该顶点径向扫描模具 扫描模板旋转。 在另一个优选实施例中，提供了用于压缩乳房皮肤表面的柔性膜，柔性膜被安装在诸如辊组件的机械组件上以形成狭缝状开口，超声波换能器通过该槽开口直接接触皮肤表面 ，柔性膜相对于皮肤表面上升和下降，但是当狭缝状开口和超声换能器横向压缩的乳房移动时横向移动，从而同时实现乳房的稳定和直接的换能器 - 皮肤接触。