公开(公告)号：US12027358B2

公开(公告)日：2024-07-02

申请号：US17216988

申请日：2021-03-30

Applicant: Shimadzu Corporation

Inventor： Wenjian Sun ,  Ran Qiu ,  Xiaoqiang Zhang

IPC: H01J49/00 ,  G01N30/72

CPC classification number: H01J49/0072 ,  G01N30/7206 ,  G01N30/7233 ,  H01J49/0036

Abstract: The invention provides a mass spectrometry analysis method and a mass spectrometry system, including: a first sample separation step, separating a sample by a first sample separation device to obtain first isolates; a second sample separation step, introducing ionized first isolates into a second sample separation device for further separation based on a difference in ion mobility to obtain second isolates; and a mass spectrometry analysis step, performing mass spectrometry detection at least on daughter ions obtained from dissociation of the second isolates; in the second sample separation step, the second sample separation device operates in a filter mode, and screens out and releases ions having ion mobility within a specified range from received second isolates. The mass spectrometry analysis method can improve the dynamic range of mass spectrometry analysis.

公开(公告)号：US11289318B2

公开(公告)日：2022-03-29

申请号：US17212168

申请日：2021-03-25

Applicant: Shimadzu Corporation

Inventor： Xinfeng Zhou ,  Ran Qiu ,  Wenjian Sun

IPC: H01J49/00 ,  H01J49/42 ,  H01J49/40 ,  G01N30/72 ,  G01N30/02

Abstract: The invention provides a mass spectrometry analysis method and a mass spectrometry system. During implementation of the mass spectrometry analysis method, intensity data of the daughter ions, a first parameter of the daughter ions associated with the first physicochemical property, and a second parameter of the daughter ions associated with the second physicochemical property are all recorded to form a spectrogram data set. In a deconvolution step, the spectrogram data set is deconvoluted to categorize the daughter ions from the same parent ion according to two-dimensional features including the first parameter and the second parameter. In the above manner, the mass spectrometry analysis method and the mass spectrometry system provided by the invention can detect ions that partially overlap spectral peaks of other ions significantly, thereby improving the qualitative and quantitative ability of data analysis for data independent acquisition.