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公开(公告)号:US09540301B2
公开(公告)日:2017-01-10
申请号:US14113498
申请日:2012-04-26
IPC分类号: C07C51/09 , C07F9/40 , C07C57/03 , A61K31/167 , A61K31/202 , A61K33/16 , A61K35/742 , A61K35/744 , A61K45/06 , C07C67/343 , C07C51/353 , A61K9/48
CPC分类号: C07C51/09 , A61K9/4858 , A61K9/4866 , A61K9/4875 , A61K31/167 , A61K31/202 , A61K33/16 , A61K35/742 , A61K35/744 , A61K45/06 , C07C51/353 , C07C57/03 , C07C67/343 , C07F9/4015 , A61K2300/00 , C07C69/587
摘要: Provided is a method of manufacturing a high quality phosphonocrotonic acid derivative.The present invention is a method of manufacturing a compound represented by the following Formula (3) by reacting a compound represented by the following Formula (1) with a compound represented by the following Formula (2), which comprises a treatment process using an acid or base.[in the formula, R1 represents a C1-6 linear or branched alkyl group that may be substituted by a C6-10 aryl group, a C2-6 linear or branched alkenyl group that may be substituted by a C6-10 aryl group, a C2-6 linear or branched alkynyl group that may be substituted by a C6-10 aryl group, or a C6-10 aryl group, R2 represents a hydrogen atom, or a C1-6 linear or branched alkyl group that may be substituted by a C6-10 aryl group, R3 represents a C1-6 linear or branched alkyl group, a C6-10 aryl group, or a halogen atom, and X represents a halogen atom, and multiple R1s may be the same or different].
摘要翻译: 提供制造高品质膦酸巴豆酸衍生物的方法。 本发明是通过使由下式(1)表示的化合物与下式(2)表示的化合物反应来制备由下式(3)表示的化合物的方法,该方法包括使用酸 或基地。 [式中,R 1表示可以被C 6-10芳基取代的C 1-6直链或支链烷基,可以被C 6-10芳基取代的C 2-6直链或支链烯基, 10芳基,可以被C 6-10芳基取代的C 2-6直链或支链炔基或C 6-10芳基,R 2表示氢原子或C 1-6直链 或可被C 6-10芳基取代的支链烷基,R 3表示C 1-6直链或支链烷基,C 6-10芳基或卤素原子,X表示卤素原子 ,多个R 1可以相同或不同]。
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公开(公告)号:US20140051876A1
公开(公告)日:2014-02-20
申请号:US14113498
申请日:2012-04-26
CPC分类号: C07C51/09 , A61K9/4858 , A61K9/4866 , A61K9/4875 , A61K31/167 , A61K31/202 , A61K33/16 , A61K35/742 , A61K35/744 , A61K45/06 , C07C51/353 , C07C57/03 , C07C67/343 , C07F9/4015 , A61K2300/00 , C07C69/587
摘要: Provided is a method of manufacturing a high quality phosphonocrotonic acid derivative.The present invention is a method of manufacturing a compound represented by the following Formula (3) by reacting a compound represented by the following Formula (1) with a compound represented by the following Formula (2), which comprises a treatment process using an acid or base.[in the formula, R1 represents a C1-6 linear or branched alkyl group that may be substituted by a C6-10 aryl group, a C2-6 linear or branched alkenyl group that may be substituted by a C6-10 aryl group, a C2-6 linear or branched alkynyl group that may be substituted by a C6-10 aryl group, or a C6-10 aryl group, R2 represents a hydrogen atom, or a C1-6 linear or branched alkyl group that may be substituted by a C6-10 aryl group, R3 represents a C1-6 linear or branched alkyl group, a C6-10 aryl group, or a halogen atom, and X represents a halogen atom, and multiple R1s may be the same or different].
摘要翻译: 提供制造高品质膦酸巴豆酸衍生物的方法。 本发明是通过使由下式(1)表示的化合物与下式(2)表示的化合物反应来制备由下式(3)表示的化合物的方法,该方法包括使用酸 或基地。 [式中,R 1表示可被C 6-10芳基取代的C 1-6直链或支链烷基,可被C 6-10芳基取代的C 2-6直链或支链烯基, 可被C 6-10芳基或C 6-10芳基取代的C 2-6直链或支链炔基,R 2表示氢原子,或可被C 1-6烷基取代的C 1-6直链或支链烷基 C6-10芳基,R3表示C1-6直链或支链烷基,C6-10芳基或卤素原子,X表示卤素原子,多个R1可以相同或不同]。
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公开(公告)号:US5752985A
公开(公告)日:1998-05-19
申请号:US833429
申请日:1997-04-07
摘要: Apparatus comprising an outside-air conditioner 2, an operation zone 4, a ceiling filter 8 such as an HEPA or ULPA filter, a fan filter unit 9 comprising a chemical filter and a draft fan arranged only on an overhead carrying apparatus 5 and storing apparatus 6 arranged in the operation zone 4 in a clean room 1 chemical mist causing chemical contamination is removed to the carrying apparatus 5 and storing apparatus 6.
摘要翻译: 包括外部空气调节器2,操作区域4,诸如HEPA或ULPA过滤器的顶棚过滤器8的装置,包括仅在架空运输装置5上设置的化学过滤器和通风扇的风扇过滤器单元9和存储装置 6,在清洁室内配置在操作区域4中,导致化学污染的化学雾被移除到运送装置5和存储装置6。
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公开(公告)号:US5827339A
公开(公告)日:1998-10-27
申请号:US829954
申请日:1997-04-01
CPC分类号: F24F3/1603 , F24F2003/144 , F24F2003/1621
摘要: A clean dry air generating unit that includes a fan filter unit and a dry air generating apparatus arranged within a chamber of closed construction. The fan filter unit includes an open air introducing fan, a chemical filter, and a HEPA filter. The chamber of closed construction is supplied air through the fan filter unit which is then supplied to the dry air generating apparatus. Clean dry air is fed from the generating unit to an area outside of the chamber or can be reintroduced to the generating unit. The apparatus can continuously supply clean dry air at a lower cost.
摘要翻译: 一种清洁的干燥空气发生单元,其包括布置在封闭结构的室内的风扇过滤器单元和干燥空气发生装置。 风扇过滤器单元包括空气引入风扇,化学过滤器和HEPA过滤器。 封闭结构的室通过风扇过滤器单元供应空气,然后将其供应到干燥空气发生装置。 清洁的干燥空气从发生单元进料到室外的区域,或者可以重新引入生成单元。 该设备可以以较低的成本连续供应干净的干燥空气。
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