公开(公告)号：US06821306B2

公开(公告)日：2004-11-23

申请号：US10098405

申请日：2002-03-18

申请人： Shinya Tachibana ,  Yasuo Yonou ,  Naoto Hirano ,  Shigemitsu Abe

发明人： Shinya Tachibana ,  Yasuo Yonou ,  Naoto Hirano ,  Shigemitsu Abe

IPC分类号： B01D900

CPC分类号： C07H19/16

摘要： Herein is disclosed a method for producing mixed crystals of disodium 5′-guanylate and disodium 5′-inosinate which comprises feeding a mixed solution of disodium 5′-guanylate and disodium 5′-inosinate which solution will become supersaturated at the below-mentioned constant temperature, to a solution or slurry of disodium 5′-guanylate and disodium 5′-inosinate charged in a crystallization bath (lower-temperature bath) and kept at a constant temperature, whereby mixed crystals of disodium 5′-guanylate and disodium 5′-inosinate are deposited from the mixed solution of disodium 5′-guanylate and disodium 5′-inosinate, according to which method 5′-GMP2Na which is difficult to handle due to the properties and powder characteristic of its crystals in particular and 5′-IMP2Na, in the form of crystals which are easy to handle, that is, I+G mixed crystals having a given I/G ratio, can be produced under simple process control and with inexpensive facilities, with the I/G ratio being controlled easily.

摘要翻译： 本发明公开了一种制备5'-鸟苷酸二钠和5'-肌苷酸二钠的混合晶体的方法，该方法包括将5'-鸟苷酸二钠和5'-肌苷酸二钠的混合溶液加入到下述常数中变成过饱和的溶液 温度，加入到在结晶浴（低温浴）中的5'-鸟苷酸二钠和5'-肌苷二钠的溶液或浆液中，并保持在恒定温度，由此将5'-鸟苷酸二钠和5' 由5'-鸟苷酸二钠和5'-肌苷酸二钠的混合溶液沉积 - 硫氰酸钠，根据该方法由于其晶体的特性和粉末特性以及5'- 以易于处理的晶体形式的IMP2Na，即具有给定I / G比的I + G混晶，可以在简单的工艺控制下和廉价的设备下生产，I / G比例被控制为ea 。。

公开(公告)号：US07354615B2

公开(公告)日：2008-04-08

申请号：US10481893

申请日：2002-07-19

申请人： Toyokazu Kaneko ,  Yasuo Yonou ,  Naoto Hirano ,  Shigemitsu Abe ,  Kunihiko Toumori

发明人： Toyokazu Kaneko ,  Yasuo Yonou ,  Naoto Hirano ,  Shigemitsu Abe ,  Kunihiko Toumori

IPC分类号： A23L1/221 ,  B01D9/00

CPC分类号： C07H1/00 ,  C07H19/20

摘要： Disclosed herein are a process for producing mixed crystals of disodium 5′-guanylate and disodium 5′-inosinate which comprises precipitating mixed crystals of disodium 5′-guanylate and disodium 5′-inosinate (I+G mixed crystals) by adding an aqueous mixed solution of disodium 5′-guanylate and disodium 5′-inosinate and a hydrophilic organic solvent at the same time into a crystallization vessel in such manner that the ratio of the hydrophilic organic solvent to the liquid phase in the crystallization vessel is maintained in a range of 30 to 70 vol %, as well as such process for producing I+G mixed crystals wherein said producing of I+G mixed crystals is carried out by seeding crystallization wherein crystals of 5′-IMP2Na or/and I+G mixed crystals are used as seed crystals. According to these production processes, the by-production of amorphous solids of 5′-GMP2Na which adversely affect separability of the crystals concerned, is inhibited, and therefore, such mixed crystals having a good separability without contamination of such amorphous solids, can be produced in a high productivity.

摘要翻译： 本文公开了一种生产5'-鸟苷酸二钠和5'-肌苷酸二钠的混合晶体的方法，该方法包括通过加入含水混合物来沉淀5'-鸟苷酸二钠和5'-肌苷酸二钠（I + G混合晶体）的混合物 5'-鸟苷酸二钠和5'-肌苷酸二钠和亲水性有机溶剂的溶液同时放入结晶容器中，使得结晶容器中的亲水性有机溶剂与液相的比率保持在一定范围内 为30〜70体积％，以及这种I + G混合晶体的制造方法，其中所述I + G混晶的制造是通过晶种结晶进行的，其中5'-IMP2Na或/和I + G混合晶体的晶体为 用作晶种。 根据这些制造方法，抑制了对相关晶体的分离性有不利影响的5-GMP2Na的无定形固体的副产物，因此可以制备这种具有良好分离性而不会污染这种无定形固体的混合晶体 在高生产力。