公开(公告)号：US20170298058A1

公开(公告)日：2017-10-19

申请号：US15371896

申请日：2016-12-07

申请人： Shionogi & Co., Ltd.,

发明人： Hiroyuki KAI ,  Satoru TANAKA ,  Yoshiharu HIRAMATSU ,  Azusa NOZU ,  Ken'ichioh NAKAMAURA

IPC分类号： C07D417/14 ,  C07D413/14 ,  C07D413/12 ,  C07D405/14 ,  C07D403/12 ,  C07D239/47 ,  C07D401/14 ,  C07D401/12 ,  C07D239/545 ,  C07D239/48 ,  C07D417/12 ,  C07D405/12

CPC分类号： C07D417/14 ,  A61K31/506 ,  C07D239/47 ,  C07D239/48 ,  C07D239/54 ,  C07D239/545 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

摘要： The present invention provides novel compounds having a P2X3 and/or P2X2/3 receptor antagonistic effect, e.g. a compound of Formula (I): wherein R2 is a hydrogen atom or the like; ring A is five- to seven-cycloalkane or the like; C is a carbon atom; Q1 and Q2 are carbon atoms or the like; R9a and R9b are carbon atoms or the like; R6 is cycloalkyl or the like; R7 is a group represented by the formula: wherein ring D is benzene or the like; carbon atom a and b are carbon atoms; ring B is an aromatic carbocyclic ring or the like; s and s′ are 0 or the like; R9 and R9′ are halogen or the like, or the like, or its pharmaceutically acceptable salt.

公开(公告)号：US20160024072A1

公开(公告)日：2016-01-28

申请号：US14377331

申请日：2013-02-08

申请人： Shionogi & Co., Ltd.

发明人： Hiroyuki KAI ,  Satoru TANAKA ,  Yoshiharu HIRAMATSU ,  Azusa NOZU ,  Ken'ichioh NAKAMURA

IPC分类号： C07D417/14 ,  C07D239/545 ,  C07D417/12 ,  C07D403/12 ,  C07D405/14 ,  C07D413/12 ,  C07D413/14 ,  C07D401/14 ,  C07D401/12 ,  C07D405/12

CPC分类号： C07D417/14 ,  A61K31/506 ,  C07D239/47 ,  C07D239/48 ,  C07D239/54 ,  C07D239/545 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

摘要： The present invention provides novel compounds having a P2X3 and/or P2X2/3 receptor antagonistic effect, e.g. a compound of Formula (I): wherein R2 is a hydrogen atom or the like; ring A is five- to seven-cycloalkane or the like; C is a carbon atom; Q1 and Q2 are carbon atoms or the like; R9a and R9b are carbon atoms or the like; R6 is cycloalkyl or the like; R7 is a group represented by the formula: wherein ring D is benzene or the like; carbon atom a and b are carbon atoms; ring B is an aromatic carbocyclic ring or the like; s and s′ are 0 or the like; R9 and R9′ are halogen or the like, or the like, or its pharmaceutically acceptable salt.

摘要翻译： 本发明提供具有P2X3和/或P2X2 / 3受体拮抗作用的新化合物，例如 式（I）的化合物：其中R2是氢原子等; 环A为五至七环烷烃等; C是碳原子; Q1和Q2是碳原子等; R9a和R9b是碳原子等; R6是环烷基等; R7为下式所示的基团：其中环D为苯等; 碳原子a和b是碳原子; 环B是芳族碳环等; s和s'为0等; R9和R9'是卤素等，或其药学上可接受的盐。