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    Activator for Peroxisome Proliferator-Activated Receptor
    2.
    发明申请
    Activator for Peroxisome Proliferator-Activated Receptor 审中-公开
    过氧化物酶体增殖物激活受体活化剂

    公开(公告)号：US20090203908A1

    公开(公告)日：2009-08-13

    申请号：US11920940

    申请日：2006-05-24

    申请人： Shogo Sakuma ,  Nobutaka Mochiduki ,  Rie Takahashi ,  Toshitake Hirai ,  Tomio Yamakawa ,  Seiichiro Masui

    发明人： Shogo Sakuma ,  Nobutaka Mochiduki ,  Rie Takahashi ,  Toshitake Hirai ,  Tomio Yamakawa ,  Seiichiro Masui

    IPC分类号： C07D417/06

    CPC分类号： C07D277/28

    摘要： A compound having the following formula or its salt is used as an activator for PPAR: in which W2 represents a bond, C(═O) or CH2; Z2 represents an oxygen or sulfur atom; R21, R22 and R23 independently represent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, a halogen atom, an alkyl group having 1 to 8 carbon atoms which is substituted with a halogen atom or the like; and R24 and R25 independently represent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms or an alkyl group having 1 to 8 carbon atoms which is substituted with a halogen atom.

    摘要翻译： 具有下式的化合物或其盐用作PPAR的活化剂：其中W 2表示键，C（-O）或CH 2; Z2表示氧或硫原子; R 21，R 22和R 23独立地表示氢原子，碳原子数1〜8的烷基，碳原子数1〜8的烷氧基，卤原子，碳原子数1〜8的被卤素取代的烷基 原子等; R 24和R 25独立地表示氢原子，碳原子数1〜8的烷基或碳原子数1〜8的被卤素原子取代的烷基。

    ACTIVATING AGENT FOR PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR
    7.
    发明申请
    ACTIVATING AGENT FOR PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR 有权
    过氧化物促进剂活化受体的激活剂

    公开(公告)号：US20110098480A1

    公开(公告)日：2011-04-28

    申请号：US12937986

    申请日：2009-04-15

    申请人： Shogo Sakuma ,  Rie Takahashi ,  Hideki Nakamura

    发明人： Shogo Sakuma ,  Rie Takahashi ,  Hideki Nakamura

    IPC分类号： C07D413/02 ,  C07D333/56

    CPC分类号： C07D333/56 ,  C07D333/58 ,  C07D413/06

    摘要： A compound represented by the formula (I) or a pharmacologically acceptable salt thereof is used as an activator of PPAR. wherein each of R1 and R2 is hydrogen, C1-8 alkyl, C1-8 alkyl substituted with halogen, or the like; each of R3, R4, R5, and R6 is hydrogen, C1-8 alkyl, or the like; X is sulfur or the like; Y is oxygen, a bond, or the like; p is 0 or 1; A is oxygen, CH2, N—NH2, or the like; when p is 1, B is phenyl, which can have a substituent; when p is 0, B is a condensed ring such as benzisoxazole, which can have a substituent; m is an integer of 1 to 4; and n is an integer of 0 to 5.

    摘要翻译： 使用由式（I）表示的化合物或其药理学上可接受的盐作为PPAR的活化剂。 其中R 1和R 2各自为氢，C 1-8烷基，被卤素取代的C 1-8烷基等; R 3，R 4，R 5和R 6各自为氢，C 1-8烷基等; X是硫等; Y是氧，键或类似物; p为0或1; A是氧，CH 2，N-NH 2等; 当p为1时，B为可具有取代基的苯基; 当p为0时，B为可以具有取代基的苯并异恶唑等稠环; m为1〜4的整数。 n为0〜5的整数。

    Activating agent for peroxisome proliferator activated receptor
    8.
    发明授权
    Activating agent for peroxisome proliferator activated receptor 有权
    过氧化物酶体增殖物激活受体的活化剂

    公开(公告)号：US08648208B2

    公开(公告)日：2014-02-11

    申请号：US12937986

    申请日：2009-04-15

    申请人： Shogo Sakuma ,  Rie Takahashi ,  Hideki Nakamura

    发明人： Shogo Sakuma ,  Rie Takahashi ,  Hideki Nakamura

    IPC分类号： C07D209/12 ,  C07D209/18 ,  A61K31/405

    CPC分类号： C07D333/56 ,  C07D333/58 ,  C07D413/06

    摘要： A compound represented by the formula (I) or a pharmacologically acceptable salt thereof is used as an activator of PPAR wherein each of R1 and R2 is hydrogen, C1-8 alkyl, C1-8 alkyl substituted with halogen, or the like; each of R3, R4, R5, and R6 is hydrogen, C1-8 alkyl, or the like; X is sulfur or the like; Y is oxygen, a bond, or the like; p is 0 or 1; A is oxygen, CH2, N—NH2, or the like; when p is 1, B is phenyl, which can have a substituent; when p is 0, B is a condensed ring such as benzisoxazole, which can have a substituent; m is an integer of 1 to 4; and n is an integer of 0 to 5.

    摘要翻译： 使用由式（I）表示的化合物或其药学上可接受的盐作为PPAR的活化剂，其中R 1和R 2各自为氢，C 1-8烷基，被卤素取代的C 1-8烷基等; R 3，R 4，R 5和R 6各自为氢，C 1-8烷基等; X是硫等; Y是氧，键或类似物; p为0或1; A是氧，CH 2，N-NH 2等; 当p为1时，B为可具有取代基的苯基; 当p为0时，B为可以具有取代基的苯并异恶唑等稠环; m为1〜4的整数。 n为0〜5的整数。

    GPR119 AGONIST
    9.
    发明申请
    GPR119 AGONIST 失效

    公开(公告)号：US20110137032A1

    公开(公告)日：2011-06-09

    申请号：US13056673

    申请日：2009-07-31

    申请人： Tsuyoshi Endo ,  Rie Takahashi ,  Hiroto Tanaka ,  Toshihiro Kunigami ,  Takaichi Hamano ,  Mai Okamura ,  Kaoru Hara

    发明人： Tsuyoshi Endo ,  Rie Takahashi ,  Hiroto Tanaka ,  Toshihiro Kunigami ,  Takaichi Hamano ,  Mai Okamura ,  Kaoru Hara

    IPC分类号： C07D401/04 ,  C07D413/14 ,  C07D401/14

    CPC分类号： C07D413/14 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/501 ,  A61K31/506 ,  C07D401/04 ,  C07D401/14

    摘要： A cyclic amine derivative represented by the formula (II) is a GPR119 agonist, and is used as an agent for treating diabetes. wherein Ar0 is phenyl or phenyl having a substituent such as C1-8 alkylsulfonyl or the like, pyridyl, or pyridyl having a substituent such as C1-8 alkylsulfonyl;A0 is (CH2)p, O, or the like;B0 is (CH2)q, or the like, provided that B0 is neither O nor NR25 when A0 is O or NR24;one of U0 and V0 is N, and the other is N or CR26;each of X0 and Y0 is C1-3 alkylene or C1-3 alkylene having a substituent;R23 is a C1-8 alkyl group or the like;each of R21 and R22 is hydrogen, a halogen atom, or the like.

    摘要翻译： 由式（II）表示的环胺衍生物是GPR119激动剂，用作治疗糖尿病的药剂。 其中Ar 0是苯基或具有取代基的苯基，例如C1-8烷基磺酰基等，吡啶基或具有取代基的吡啶基，例如C1-8烷基磺酰基; A 0为（CH 2）p，O等; B0为（CH2）q等，条件是当A0为O或NR24时，B0既不为O也不为NR25; U0和V0之一是N，另一个是N或CR26; X0和Y0各自为C1-3亚烷基或具有取代基的C1-3亚烷基; R 23是C 1-8烷基等; R 21和R 22各自为氢，卤素原子等。

    MANIPULATOR AND METHOD OF CONTROLLING THE SAME
    10.
    发明申请
    MANIPULATOR AND METHOD OF CONTROLLING THE SAME 有权
    操纵器及其控制方法

    公开(公告)号：US20100318224A1

    公开(公告)日：2010-12-16

    申请号：US12866959

    申请日：2009-03-05

    申请人： Akinobu Okuda ,  Soichiro Fujioka ,  Osamu Mizuno ,  Yoshihiko Matsukawa ,  Tsuyoshi Tojo ,  Rie Takahashi ,  Tohru Nakamura

    发明人： Akinobu Okuda ,  Soichiro Fujioka ,  Osamu Mizuno ,  Yoshihiko Matsukawa ,  Tsuyoshi Tojo ,  Rie Takahashi ,  Tohru Nakamura

    IPC分类号： B25J13/08 ,  B25J17/02 ,  B25J18/00 ,  B25J9/00 ,  G05B15/00 ,  G06F19/00 ,  B25J19/06

    CPC分类号： B25J9/1676 ,  G05B2219/39082 ,  Y10T74/20329

    摘要： A manipulator is provided with an arm, an arm, a holding section, a first joint section pivotally interconnecting the arm and the arm, a second joint section pivotally interconnecting the arm and the holding section, a first joint driving section capable of driving the first joint section, a second joint driving section capable of driving the second joint section, a member specifying section for specifying one of the arms which has a possibility of collision with an obstacle or which has collided with the obstacle, and a control device for controlling the first joint driving section and the second joint driving section to pivotally move the one of the arms specified by the member specifying section in a direction away from the obstacle, and pivotally move the other of the arms in a direction toward the obstacle.

    摘要翻译： 操纵器具有臂，臂，保持部，枢转地互连臂和臂的第一接合部，将臂和保持部枢转地相互连接的第二接头部，能够驱动第一接头的第一接头驱动部 接合部，能够驱动第二接合部的第二关节驱动部，用于指定具有与障碍物碰撞的可能性或与障碍物碰撞的一个臂的部件指定部，以及用于控制 第一关节驱动部和第二关节驱动部，用于使远离障碍物的方向枢转地移动由构件指定部指定的臂中的一个臂，并且使臂中的另一个朝向障碍物的方向。