-
公开(公告)号:US20100029949A1
公开(公告)日:2010-02-04
申请号:US11988354
申请日:2006-07-04
申请人: Shogo Sakuma , Nobutaka Mochiduki , Rie Takahashi , Toshitake Hirai , Tomio Yamakawa , Seiichiro Masui
发明人: Shogo Sakuma , Nobutaka Mochiduki , Rie Takahashi , Toshitake Hirai , Tomio Yamakawa , Seiichiro Masui
IPC分类号: C07D413/14 , C07D261/20
CPC分类号: C07D413/06 , C07D405/06 , C07D409/06 , C07D413/14 , C07D417/06
摘要: A compound having the following formula (II) or its salt is used as an activator for PPAR δ: [in which W3 is a nitrogen atom or CH; Z1 is an oxygen atom or a sulfur atom; each of R11 and R12 is a hydrogen atom, a halogen atom, a C1-C8 alkyl group, a C1-C8 alkoxy group, a C1-C8 alkyl group having a halogen substituent, or the like; each of R13 and R14 is a hydrogen atom or a C1-C8 alkyl group; A1 is pyrazole or thiophene which may have a substituent; and m is an integer of 2 to 4].
摘要翻译: 使用具有下式(II)或其盐的化合物作为PPARδ的活化剂:[其中W3是氮原子或CH; Z1是氧原子或硫原子; R 11和R 12各自为氢原子,卤素原子,C1-C8烷基,C1-C8烷氧基,具有卤素取代基的C1-C8烷基等; R 13和R 14各自为氢原子或C 1 -C 8烷基; A1是可以具有取代基的吡唑或噻吩; m为2〜4的整数]。
-
公开(公告)号:US20090203908A1
公开(公告)日:2009-08-13
申请号:US11920940
申请日:2006-05-24
申请人: Shogo Sakuma , Nobutaka Mochiduki , Rie Takahashi , Toshitake Hirai , Tomio Yamakawa , Seiichiro Masui
发明人: Shogo Sakuma , Nobutaka Mochiduki , Rie Takahashi , Toshitake Hirai , Tomio Yamakawa , Seiichiro Masui
IPC分类号: C07D417/06
CPC分类号: C07D277/28
摘要: A compound having the following formula or its salt is used as an activator for PPAR: in which W2 represents a bond, C(═O) or CH2; Z2 represents an oxygen or sulfur atom; R21, R22 and R23 independently represent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, a halogen atom, an alkyl group having 1 to 8 carbon atoms which is substituted with a halogen atom or the like; and R24 and R25 independently represent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms or an alkyl group having 1 to 8 carbon atoms which is substituted with a halogen atom.
摘要翻译: 具有下式的化合物或其盐用作PPAR的活化剂:其中W 2表示键,C(-O)或CH 2; Z2表示氧或硫原子; R 21,R 22和R 23独立地表示氢原子,碳原子数1〜8的烷基,碳原子数1〜8的烷氧基,卤原子,碳原子数1〜8的被卤素取代的烷基 原子等; R 24和R 25独立地表示氢原子,碳原子数1〜8的烷基或碳原子数1〜8的被卤素原子取代的烷基。
-
3.
公开(公告)号:US20090240058A1
公开(公告)日:2009-09-24
申请号:US11885265
申请日:2006-02-28
申请人: Shogo Sakuma , Tomio Yamakawa , Nobutaka Mochiduki , Seiichiro Masui , Rie Takahashi , Toshitake Hirai
发明人: Shogo Sakuma , Tomio Yamakawa , Nobutaka Mochiduki , Seiichiro Masui , Rie Takahashi , Toshitake Hirai
IPC分类号: C07D401/02 , C07D231/12 , C07D333/24
CPC分类号: C07D231/12 , C07D207/325 , C07D207/333 , C07D231/22 , C07D307/42 , C07D307/46 , C07D333/16 , C07D333/22 , C07D401/04 , C07D405/04 , C07D409/04
摘要: A compound or its salt having the following formula (II) is used as an activator for PPAR δ: in which each of R11 and R13 is a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms and a halogen atom substituent, etc.; R12 is a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, an alkyl group having 1 to 8 carbon atoms and a halogen atom substituent, etc.; each of R14 and R15 is a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, or an alkyl group having 1 to 8 carbon atoms and a halogen atom substituent; X1 is CH or N; Z1 is an oxygen atom or a sulfur atom; W1 is an oxygen atom or CH2; and q is an integer of 2 to 4.
摘要翻译: 使用具有下式(II)的化合物或其盐作为PPARδ的活化剂:其中R11和R13各自为氢原子,具有1至8个碳原子的烷基,具有1至8个碳原子的烷氧基 碳原子数为1〜8的烷基,卤原子取代基等。 R12为氢原子,碳原子数1〜8的烷基,碳原子数1〜8的烷氧基,碳原子数1〜8的烷基和卤素原子取代基等。 R 14和R 15各自为氢原子,碳原子数1〜8的烷基或碳原子数1〜8的烷基和卤原子取代基。 X1是CH或N; Z1是氧原子或硫原子; W1是氧原子或CH2; q为2〜4的整数。
-
公开(公告)号:US20130217734A1
公开(公告)日:2013-08-22
申请号:US13765540
申请日:2013-02-12
申请人: Shogo Sakuma , Nobutaka Mochiduki , Rie Takahashi , Masatoshi Ushioda , Tomio Yamakawa , Seiichiro Masui
发明人: Shogo Sakuma , Nobutaka Mochiduki , Rie Takahashi , Masatoshi Ushioda , Tomio Yamakawa , Seiichiro Masui
IPC分类号: C07D277/22
CPC分类号: C07D277/22 , C07D263/32 , C07D277/20 , C07D277/30 , C07D333/22
摘要: A compound represented by the following general formula (II) or a salt thereof is used as an activator of PPARδ. wherein Ga is O, CH2 or the like; Aa is thiazole, oxazole, or thiophene, which can have a substituent such as C1-8 alkyl, C1-8 alkoxy, halogen, C1-8 alkyl substituted with halogen or the like; Ba is a C1-8 alkylene or C2-8 alkenylene chain; and each of R1a and R2a independently is hydrogen, C1-8 alkyl, C1-8 alkoxy, halogen, C1-8 alkyl substituted with halogen or the like.
-
5.
公开(公告)号:US08404726B2
公开(公告)日:2013-03-26
申请号:US12297436
申请日:2007-04-18
申请人: Shogo Sakuma , Nobutaka Mochiduki , Rie Takahashi , Masatoshi Ushioda , Tomio Yamakawa , Seiichiro Masui
发明人: Shogo Sakuma , Nobutaka Mochiduki , Rie Takahashi , Masatoshi Ushioda , Tomio Yamakawa , Seiichiro Masui
IPC分类号: A61K31/426 , C07D277/30 , A61P3/00 , A61P9/10
CPC分类号: C07D277/22 , C07D263/32 , C07D277/20 , C07D277/30 , C07D333/22
摘要: A compound represented by the following general formula (II) or a salt thereof is used as an activator of PPARδ. wherein Ga is O, CH2 or the like; Aa is thiazole, oxazole, or thiophene, which can have a substituent such as C1-8 alkyl, C1-8 alkoxy, halogen, C1-8 alkyl substituted with halogen or the like; Ba is a C1-8 alkylene or C2-8 alkenylene chain; and each of R1a and R2a independently is hydrogen, C1-8 alkyl, C1-8 alkoxy, halogen, C1-8 alkyl substituted with halogen or the like.
摘要翻译: 使用由以下通式(II)表示的化合物或其盐作为PPARδ的活化剂。 其中Ga是O,CH 2等; Aa是噻唑,恶唑或噻吩,其可以具有取代基,例如C 1-8烷基,C 1-8烷氧基,卤素,被卤素取代的C 1-8烷基等; Ba是C 1-8亚烷基或C 2-8亚烯基链; R 1a和R 2a各自独立地为氢,C 1-8烷基,C 1-8烷氧基,卤素,被卤素等取代的C 1-8烷基。
-
6.
公开(公告)号:US20090298896A1
公开(公告)日:2009-12-03
申请号:US12297436
申请日:2007-04-18
申请人: Shogo Sakuma , Nobutaka Mochiduki , Rie Takahashi , Masatoshi Ushioda , Tomio Yamakawa , Seiichiro Masui
发明人: Shogo Sakuma , Nobutaka Mochiduki , Rie Takahashi , Masatoshi Ushioda , Tomio Yamakawa , Seiichiro Masui
IPC分类号: A61K31/426 , C07D277/30 , A61P3/00 , A61P9/10
CPC分类号: C07D277/22 , C07D263/32 , C07D277/20 , C07D277/30 , C07D333/22
摘要: A compound represented by the following general formula (II) or a salt thereof is used as an activator of PPARδ. wherein Ga is O, CH2 or the like; Aa is thiazole, oxazole, or thiophene, which can have a substituent such as C1-8 alkyl, C1-8 alkoxy, halogen, C1-8 alkyl substituted with halogen or the like; Ba is a C1-8 alkylene or C2-8 alkenylene chain; and each of R1a and R2a independently is hydrogen, C1-8 alkyl, C1-8 alkoxy, halogen, C1-8 alkyl substituted with halogen or the like.
摘要翻译: 使用由以下通式(II)表示的化合物或其盐作为PPARδ的活化剂。 其中Ga是O,CH 2等; Aa是噻唑,恶唑或噻吩,其可以具有取代基,例如C 1-8烷基,C 1-8烷氧基,卤素,被卤素取代的C 1-8烷基等; Ba是C 1-8亚烷基或C 2-8亚烯基链; R 1a和R 2a各自独立地为氢,C 1-8烷基,C 1-8烷氧基,卤素,被卤素等取代的C 1-8烷基。
-
公开(公告)号:US07652045B2
公开(公告)日:2010-01-26
申请号:US11888493
申请日:2007-07-31
申请人: Shogo Sakuma , Tomio Yamakawa , Takashi Kanda , Seiichiro Masui
发明人: Shogo Sakuma , Tomio Yamakawa , Takashi Kanda , Seiichiro Masui
IPC分类号: A61K31/421 , A61K31/426 , C07D263/30 , C07D277/20
CPC分类号: C07D263/62 , C07D263/32 , C07D277/24
摘要: A compound represented by the following general formula (I): (wherein R1 represents phenyl, etc. which can have substituents selected from the group consisting of C1-8 alkyl, C1-8 alkyl having halogen, halogen, hydroxyl, etc.; R2 represents C1-8 alkyl, etc.; A represents oxygen, sulfur, etc.; X represents C1-8 alkylene chain, etc.; Y represents C(═O), CH═CH, etc.; R3, R4, and R5 each represents hydrogen, C1-8 alkyl, etc.; B represents CH or nitrogen; Z represents oxygen or sulfur; R6 and R7 each represents hydrogen, C1-8 alkyl, etc.; and R8 represents hydrogen or C1-8 alkyl; provided that at least one of R3, R4, and R5 is not hydrogen) or a salt of the compound; and a PPAR-δ activator which contains the compound or salt as the active ingredient.
摘要翻译: 由以下通式(I)表示的化合物:(其中R 1表示可以具有选自C 1-8烷基,具有卤素的C 1-8烷基,卤素,羟基等的取代基的苯基等; R 2 表示C1-8烷基等; A表示氧,硫等; X表示C1-8亚烷基链等; Y表示C(-O),CH-CH等; R3,R4和R5 各自表示氢,C 1-8烷基等; B表示CH或氮; Z表示氧或硫; R6和R7各自表示氢,C1-8烷基等; R8表示氢或C1-8烷基; R3,R4和R5中的至少一个不是氢)或化合物的盐; 和含有该化合物或盐作为活性成分的PPAR-δ活化剂。
-
公开(公告)号:US07648999B2
公开(公告)日:2010-01-19
申请号:US11888492
申请日:2007-07-31
申请人: Shogo Sakuma , Tomio Yamakawa , Takashi Kanda , Seiichiro Masui
发明人: Shogo Sakuma , Tomio Yamakawa , Takashi Kanda , Seiichiro Masui
IPC分类号: A61K31/426 , A61K31/4436 , A61K31/4709 , C07D277/22 , C07D417/04
CPC分类号: C07D263/62 , C07D263/32 , C07D277/24
摘要: A compound represented by the following general formula (I): (wherein R1 represents phenyl, etc. which can have substituents selected from the group consisting of C1-8 alkyl, C1-8 alkyl having halogen, halogen, hydroxyl, etc.; R2 represents C1-8 alkyl, etc.; A represents oxygen, sulfur, etc.; X represents C1-8 alkylene chain, etc.; Y represents C(═O), CH═CH, etc.; R3, R4, and R5 each represents hydrogen, C1-8 alkyl, etc.; B represents CH or nitrogen; Z represents oxygen or sulfur; R6 and R7 each represents hydrogen, C1-8 alkyl, etc.; and R8 represents hydrogen or C1-8 alkyl; provided that at least one of R3, R4, and R5 is not hydrogen) or a salt of the compound; and a PPAR-δ activator which contains the compound or salt as the active ingredient.
摘要翻译: 由以下通式(I)表示的化合物:(其中R 1表示可以具有选自C 1-8烷基,具有卤素的C 1-8烷基,卤素,羟基等的取代基的苯基等; R 2 表示C1-8烷基等; A表示氧,硫等; X表示C1-8亚烷基链等; Y表示C(-O),CH-CH等; R3,R4和R5 各自表示氢,C 1-8烷基等; B表示CH或氮; Z表示氧或硫; R6和R7各自表示氢,C1-8烷基等; R8表示氢或C1-8烷基; R3,R4和R5中的至少一个不是氢)或化合物的盐; 和含有该化合物或盐作为活性成分的PPAR-δ活化剂。
-
公开(公告)号:US07265137B2
公开(公告)日:2007-09-04
申请号:US10486783
申请日:2002-08-02
申请人: Shogo Sakuma , Tomio Yamakawa , Takashi Kanda , Seiichiro Masui
发明人: Shogo Sakuma , Tomio Yamakawa , Takashi Kanda , Seiichiro Masui
IPC分类号: A61K31/421 , A61K31/426 , C07D213/30 , C07D277/20
CPC分类号: C07D263/62 , C07D263/32 , C07D277/24
摘要: A compound represented by the following general formula (I): (wherein R1 represents phenyl, etc. which can have substituents selected from the group consisting of C1-8 alkyl, C1-8 alkyl having halogen, halogen, hydroxyl, etc.; R2 represents C1-8 alkyl, etc.; A represents oxygen, sulfur, etc.; X represents C1-8 alkylene chain, etc.; Y represents C(═O), CH═CH, etc.; R3, R4, and R5 each represents hydrogen, C1-8 alkyl, etc.; B represents CH or nitrogen; Z represents oxygen or sulfur; R6 and R7 each represents hydrogen, C1-8 alkyl, etc.; and R8 represents hydrogen or C1-8 alkyl; provided that at least one of R3, R4, and R5 is not hydrogen) or a salt of the compound; and a PPAR-δ activator which contains the compound or salt as the active ingredient.
摘要翻译: 由以下通式(I)表示的化合物:(其中R 1表示苯基等,其可以具有选自C 1-8烷基的取代基 具有卤素,卤素,羟基等的C 1-8烷基; R 2表示C 1-8烷基等; A 表示氧,硫等; X表示C 1-8亚烷基链等; Y表示C(-O),CH-CH等; R 3 O R 4,R 5和R 5各自表示氢,C 1-8烷基等; B表示CH或氮; Z表示 氧或硫; R 6和R 7各自表示氢,C 1-8烷基等;和R 8, / SUP>表示氢或C 1-8烷基,条件是R 3,R 4和R 4中的至少一个, 5不是氢)或化合物的盐; 和含有该化合物或盐作为活性成分的PPAR-δ活化剂。
-
公开(公告)号:US07402597B2
公开(公告)日:2008-07-22
申请号:US11544505
申请日:2006-10-06
申请人: Shogo Sakuma , Tomio Yamakawa , Takashi Kanda , Seiichiro Masui
发明人: Shogo Sakuma , Tomio Yamakawa , Takashi Kanda , Seiichiro Masui
IPC分类号: A61K31/4178 , A61K31/423 , A61K31/427
CPC分类号: C07D403/06 , A61K31/00 , A61K31/423 , A61K31/427 , A61K31/454 , C07D405/06 , C07D409/06 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14
摘要: A compound represented by the formula (I) or a salt of the compound, and a PPAR-δ activator which contains the compound or salt as the active ingredient: (wherein A represents O or S; B1 represents N, etc.; B2 represents O, etc.; each of X1 and X2 represents O, S, a bond, etc.; Y represents C1-8 alkylene chain; z represents O or S; R1 represents aryl, etc. which can have substituents; R2 represents C1-8 alkyl, etc.; R3 represents C1-8 alkyl, C2-8 alkenyl, etc.; each of R4 and R5 represents hydrogen, C1-8 alkyl, etc.; and R6 represents hydrogen, etc.; provided that each of Z and R3 is attached to the benzene ring, and X2 is not attached to the benzene ring).
摘要翻译: 由式(I)表示的化合物或化合物的盐和含有该化合物或盐作为活性成分的PPAR-δ活化剂:(其中A表示O或S; B < 表示N等; B 2表示O等; X 1和X 2各自表示O,S,键, Y表示C 1-8亚烷基链; z表示O或S; R 1表示可具有取代基的芳基等; R 2, / SUP表示C 1-8烷基等; R 3表示C 1-8烷基,C 2-8 链烯基等; R 4和R 5各自代表氢,C 1-8烷基等;和 R 6表示氢等;条件是Z和R 3各自连接到苯环上,并且X 2不连接 到苯环)。
-
-
-
-
-
-
-
-
-