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公开(公告)号：US20100093828A1
公开(公告)日：2010-04-15
申请号：US12310303
申请日：2007-08-20
申请人： Keizo Koya , Lijun Sun , Shoujun Chen , Jun Jiang
发明人： Keizo Koya , Lijun Sun , Shoujun Chen , Jun Jiang
IPC分类号： A61K31/165 , C07C327/56 , C07D333/24 , C07D307/54 , A61K31/381 , A61K31/341 , A61P35/00 , A61P25/16 , A61P25/28
CPC分类号： C07C327/56 , C07C337/08 , C07C2601/14 , C07C2601/18 , C07D211/84 , C07D213/53 , C07D239/04 , C07D263/10 , C07D271/10 , C07D307/52 , C07D317/28 , C07D333/22 , C07D339/08 , C07D413/14
摘要： Disclosed are compounds of formula (IA), formula (IV) or formula (V), and pharmaceutical compositions containing them which are useful for treating a subject with a proliferative disorder, such as cancer. The disclosed compounds and pharmaceutical compositions are also useful for treating disorders responsive to Hsp70 induction and/or natural killer induction.
摘要翻译： 公开了式（IA），式（IV）或式（V）的化合物和含有它们的药物组合物，其可用于治疗患有增殖性疾病如癌症的受试者。 所公开的化合物和药物组合物还可用于治疗对Hsp70诱导和/或天然杀伤诱导反应的病症。
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公开(公告)号：US20090270353A1
公开(公告)日：2009-10-29
申请号：US12496902
申请日：2009-07-02
申请人： Lijun Sun , Jun Jiang , Christopher Borella , Shoujun Chen , Keizo Koya
发明人： Lijun Sun , Jun Jiang , Christopher Borella , Shoujun Chen , Keizo Koya
IPC分类号： A61K31/427 , A61K31/425 , A61K31/4439 , A61K31/501 , A61K31/506 , A61K31/675
CPC分类号： C07D275/02 , A61K31/425 , A61K31/4439 , A61K31/506 , C07D417/04 , C07D417/10 , C07F9/6539 , C07F9/65586
摘要： The invention relates to compounds of structural formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, and prodrug thereof, wherein Ra, Rb, and R2 are defined herein. These compounds inhibit tubulin polymerization and/or target vasculature and are useful for treating proliferative disorders, such as cancer.
摘要翻译： 本发明涉及结构式（I）的化合物或其药学上可接受的盐，溶剂化物，包合物和前药，其中R a，R b和R 2在本文中定义。 这些化合物抑制微管蛋白聚合和/或靶向脉管系统，并且可用于治疗增殖性疾病如癌症。
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公开(公告)号：US20070179159A1
公开(公告)日：2007-08-02
申请号：US11601590
申请日：2006-11-17
申请人： Lijun Sun , Jun Jiang , Christopher Borella , Shoujun Chen , Keizo Koya
发明人： Lijun Sun , Jun Jiang , Christopher Borella , Shoujun Chen , Keizo Koya
IPC分类号： A61K31/506 , A61K31/4439 , A61K31/425 , C07F9/06 , C07F9/6512 , C07D417/02
CPC分类号： C07D275/02 , A61K31/425 , A61K31/4439 , A61K31/506 , C07D417/04 , C07D417/10 , C07F9/6539 , C07F9/65586
摘要： The invention relates to compounds of structural formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, and prodrug thereof, wherein Ra, Rb, and R2 are defined herein. These compounds inhibit tubulin polymerization and/or target vasculature and are useful for treating proliferative disorders, such as cancer.
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公开(公告)号：US08598366B2
公开(公告)日：2013-12-03
申请号：US13558886
申请日：2012-07-26
申请人： Lijun Sun , Christopher Borella , Hao Li , Jun Jiang , Shoujun Chen , Keizo Koya , Takayo Inoue , Zhenjian Du , Kevin Foley , Yaming Wu , Mei Zhang , Weiwen Ying
发明人： Lijun Sun , Christopher Borella , Hao Li , Jun Jiang , Shoujun Chen , Keizo Koya , Takayo Inoue , Zhenjian Du , Kevin Foley , Yaming Wu , Mei Zhang , Weiwen Ying
IPC分类号： C07D261/02
CPC分类号： C07D413/14 , A61K31/42 , A61K31/426 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/675 , A61K45/06 , C07D261/08 , C07D413/04 , C07D413/10 , C07F9/653
摘要： The invention relates to compounds of structural formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, and prodrug thereof, wherein Ra, Rb, and R2 are defined herein. These compounds inhibit tubulin polymerization and/or target vasculature and are useful for treating proliferative disorders, such as cancer.
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公开(公告)号：US20130203824A1
公开(公告)日：2013-08-08
申请号：US13785724
申请日：2013-03-05
申请人： Lijun Sun , Jun Jiang , Christopher Borella , Shoujun Chen , Keizo Koya
发明人： Lijun Sun , Jun Jiang , Christopher Borella , Shoujun Chen , Keizo Koya
IPC分类号： C07D275/02
CPC分类号： C07D275/02 , A61K31/425 , A61K31/4439 , A61K31/506 , C07D417/04 , C07D417/10 , C07F9/6539 , C07F9/65586
摘要： The invention relates to compounds of structural formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, and prodrug thereof, wherein Ra, Rb, and R2 are defined herein. These compounds inhibit tubulin polymerization and/or target vasculature and are useful for treating proliferative disorders, such as cancer.
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公开(公告)号：US20110098476A1
公开(公告)日：2011-04-28
申请号：US12934903
申请日：2009-03-31
申请人： Shoujun Chen , Jun Jiang , Lijun Sun , Keizo Koya
发明人： Shoujun Chen , Jun Jiang , Lijun Sun , Keizo Koya
IPC分类号： C07D213/44 , C07C327/48
CPC分类号： C07C327/56 , C07C2601/02 , C07D213/86 , C07D213/87
摘要： Disclosed herein are methods of preparing a bis(thio-hydrazide amides) compounds of the following structural formula: wherein R1, R2, R3, R4, R5, R6 and R13 are defined herein.
摘要翻译： 本文公开了制备以下结构式的双（硫代酰肼酰胺）化合物的方法：其中R1，R2，R3，R4，R5，R6和R13如本文所定义。
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公开(公告)号：US08633323B2
公开(公告)日：2014-01-21
申请号：US12934903
申请日：2009-03-31
申请人： Shoujun Chen , Jun Jiang , Lijun Sun , Keizo Koya
发明人： Shoujun Chen , Jun Jiang , Lijun Sun , Keizo Koya
IPC分类号： C07D213/44 , C07C327/00
CPC分类号： C07C327/56 , C07C2601/02 , C07D213/86 , C07D213/87
摘要： Disclosed herein are methods of preparing a bis(thio-hydrazide amides) compounds of the following structural formula: wherein R1, R2, R3, R4, R5, R6 and R13 are defined herein.
摘要翻译： 本文公开了制备以下结构式的双（硫代酰肼酰胺）化合物的方法：其中R1，R2，R3，R4，R5，R6和R13如本文所定义。
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公开(公告)号：US08399435B2
公开(公告)日：2013-03-19
申请号：US13269042
申请日：2011-10-07
申请人： Lijun Sun , Jun Jiang , Christopher Borella , Shoujun Chen , Keizo Koya
发明人： Lijun Sun , Jun Jiang , Christopher Borella , Shoujun Chen , Keizo Koya
IPC分类号： A61K31/675 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61P35/00 , C07D275/02 , C07D261/08 , C07D417/10 , C07F9/09 , C12N5/07
CPC分类号： C07D275/02 , A61K31/425 , A61K31/4439 , A61K31/506 , C07D417/04 , C07D417/10 , C07F9/6539 , C07F9/65586
摘要： The invention relates to compounds of structural formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, and prodrug thereof, wherein Ra, Rb, and R2 are defined herein. These compounds inhibit tubulin polymerization and/or target vasculature and are useful for treating proliferative disorders, such as cancer.
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公开(公告)号：US07884094B2
公开(公告)日：2011-02-08
申请号：US11355922
申请日：2006-02-16
申请人： Lijun Sun , Christopher Borella , Hao Li , Jun Jiang , Shoujun Chen , Keizo Koya , Takayo Inoue , Zhenjian Du , Kevin Foley , Yaming Wu , Mei Zhang , Weiwen Ying
发明人： Lijun Sun , Christopher Borella , Hao Li , Jun Jiang , Shoujun Chen , Keizo Koya , Takayo Inoue , Zhenjian Du , Kevin Foley , Yaming Wu , Mei Zhang , Weiwen Ying
IPC分类号： A61K31/33 , C07D261/02
CPC分类号： C07D413/14 , A61K31/42 , A61K31/426 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/675 , A61K45/06 , C07D261/08 , C07D413/04 , C07D413/10 , C07F9/653
摘要： The invention relates to compounds of structural formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, and prodrug thereof, wherein Ra, Rb, and R2 are defined herein. These compounds inhibit tubulin polymerization and/or target vasculature and are useful for treating proliferative disorders, such as cancer.
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公开(公告)号：US07572821B2
公开(公告)日：2009-08-11
申请号：US11601590
申请日：2006-11-17
申请人： Lijun Sun , Jun Jiang , Christopher Borella , Shoujun Chen , Keizo Koya
发明人： Lijun Sun , Jun Jiang , Christopher Borella , Shoujun Chen , Keizo Koya
IPC分类号： A61K31/425 , C07D275/03
CPC分类号： C07D275/02 , A61K31/425 , A61K31/4439 , A61K31/506 , C07D417/04 , C07D417/10 , C07F9/6539 , C07F9/65586
摘要： The invention relates to compounds of structural formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, and prodrug thereof, wherein Ra, Rb, and R2 are defined herein. These compounds inhibit tubulin polymerization and/or target vasculature and are useful for treating proliferative disorders, such as cancer.
摘要翻译： 本发明涉及结构式（I）的化合物或其药学上可接受的盐，溶剂化物，包合物和前药，其中R a，R b和R 2在本文中定义。 这些化合物抑制微管蛋白聚合和/或靶向脉管系统，并且可用于治疗增殖性疾病如癌症。
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