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    ATOMIC MAGNETIC GRADIOMETER FOR ROOM TEMPERATURE HIGH SENSITIVITY MAGNETIC FIELD DETECTION
    1.
    发明申请
    ATOMIC MAGNETIC GRADIOMETER FOR ROOM TEMPERATURE HIGH SENSITIVITY MAGNETIC FIELD DETECTION 有权
    用于房间温度高灵敏度磁场检测的原子级磁阻计

    公开(公告)号：US20070205767A1

    公开(公告)日：2007-09-06

    申请号：US11563537

    申请日：2006-11-27

    申请人： Shoujun Xu ,  Thomas Lowery ,  Dmitry Budker ,  Valeriy Yashchuk ,  David Wemmer ,  Alexander Pines

    发明人： Shoujun Xu ,  Thomas Lowery ,  Dmitry Budker ,  Valeriy Yashchuk ,  David Wemmer ,  Alexander Pines

    IPC分类号： G01V3/00

    CPC分类号： G01R33/26

    摘要： A laser-based atomic magnetometer (LBAM) apparatus measures magnetic fields, comprising: a plurality of polarization detector cells to detect magnetic fields; a laser source optically coupled to the polarization detector cells; and a signal detector that measures the laser source after being coupled to the polarization detector cells, which may be alkali cells. A single polarization cell may be used for nuclear magnetic resonance (NMR) by prepolarizing the nuclear spins of an analyte, encoding spectroscopic and/or spatial information, and detecting NMR signals from the analyte with a laser-based atomic magnetometer to form NMR spectra and/or magnetic resonance images (MRI). There is no need of a magnetic field or cryogenics in the detection step, as it is detected through the LBAM.

    摘要翻译： 基于激光的原子磁强计（LBAM）装置测量磁场，包括：多个检测磁场的偏振检测器单元; 光学耦合到所述偏振检测器单元的激光源; 以及信号检测器，其在耦合到可以是碱电池的偏振检测器单元之后测量激光源。 通过对分析物的核自旋进行预极化，编码光谱和/或空间信息，并用基于激光的原子磁强计检测来自分析物的NMR信号，可以将单个极化单元用于核磁共振（NMR），以形成NMR光谱， /或磁共振图像（MRI）。 在检测步骤中不需要磁场或低温，因为它通过LBAM检测。

    Magnetic resonance imaging of living systems by remote detection
    2.
    发明授权
    Magnetic resonance imaging of living systems by remote detection 有权
    通过远程检测生活系统的磁共振成像

    公开(公告)号：US08570035B2

    公开(公告)日：2013-10-29

    申请号：US12747488

    申请日：2008-12-12

    申请人： David Wemmer ,  Alexander Pines ,  Louis Bouchard ,  Shoujun Xu ,  Elad Harel ,  Dmitry Budker ,  Thomas Lowery ,  Micah Ledbetter

    发明人： David Wemmer ,  Alexander Pines ,  Louis Bouchard ,  Shoujun Xu ,  Elad Harel ,  Dmitry Budker ,  Thomas Lowery ,  Micah Ledbetter

    IPC分类号： G01V3/00

    CPC分类号： G01R33/0322

    摘要： A novel approach to magnetic resonance imaging is disclosed. Blood flowing through a living system is prepolarized, and then encoded. The polarization can be achieved using permanent or superconducting magnets. The polarization may be carried out upstream of the region to be encoded or at the place of encoding. In the case of an MRI of a brain, polarization of flowing blood can be effected by placing a magnet over a section of the body such as the heart upstream of the head. Alternatively, polarization and encoding can be effected at the same location. Detection occurs at a remote location, using a separate detection device such as an optical atomic magnetometer, or an inductive Faraday coil. The detector may be placed on the surface of the skin next to a blood vessel such as a jugular vein carrying blood away from the encoded region.

    摘要翻译： 公开了一种新的磁共振成像方法。 流过生命系统的血液是预极化的，然后被编码。 可以使用永磁体或超导磁体实现极化。 极化可以在要编码的区域的上游或在编码的地方进行。 在脑的MRI的情况下，流动的血液的极化可以通过将磁体放置在身体的一部分上，例如头部上游的心脏。 或者，极化和编码可以在相同的位置进行。 使用诸如光学原子磁强计之类的单独检测装置或感应式法拉第线圈在远程位置进行检测。 检测器可以放置在皮肤表面上，紧靠血管如颈静脉，血液远离编码区域。

    Atomic magnetic gradiometer for room temperature high sensitivity magnetic field detection
    7.
    发明授权
    Atomic magnetic gradiometer for room temperature high sensitivity magnetic field detection 有权
    原子磁梯度仪，用于室温高灵敏度磁场检测

    公开(公告)号：US07573264B2

    公开(公告)日：2009-08-11

    申请号：US11563537

    申请日：2006-11-27

    申请人： Shoujun Xu ,  Thomas L. Lowery ,  Dmitry Budker ,  Valeriy V. Yashchuk ,  David E. Wemmer ,  Alexander Pines

    发明人： Shoujun Xu ,  Thomas L. Lowery ,  Dmitry Budker ,  Valeriy V. Yashchuk ,  David E. Wemmer ,  Alexander Pines

    IPC分类号： G01V3/00

    CPC分类号： G01R33/26

    摘要： A laser-based atomic magnetometer (LBAM) apparatus measures magnetic fields, comprising: a plurality of polarization detector cells to detect magnetic fields; a laser source optically coupled to the polarization detector cells; and a signal detector that measures the laser source after being coupled to the polarization detector cells, which may be alkali cells. A single polarization cell may be used for nuclear magnetic resonance (NMR) by prepolarizing the nuclear spins of an analyte, encoding spectroscopic and/or spatial information, and detecting NMR signals from the analyte with a laser-based atomic magnetometer to form NMR spectra and/or magnetic resonance images (MRI). There is no need of a magnetic field or cryogenics in the detection step, as it is detected through the LBAM.

    摘要翻译： 基于激光的原子磁强计（LBAM）装置测量磁场，包括：多个检测磁场的偏振检测器单元; 光学耦合到所述偏振检测器单元的激光源; 以及信号检测器，其在耦合到可以是碱电池的偏振检测器单元之后测量激光源。 通过对分析物的核自旋进行预极化，编码光谱和/或空间信息，并用基于激光的原子磁强计检测来自分析物的NMR信号，可以将单个极化单元用于核磁共振（NMR），以形成NMR光谱， /或磁共振图像（MRI）。 在检测步骤中不需要磁场或低温，因为它通过LBAM检测。

    NMR, MRI, and Spectroscopic MRI in Inhomogeneous Fields
    10.
    发明申请
    NMR, MRI, and Spectroscopic MRI in Inhomogeneous Fields 有权
    核磁共振，MRI和光谱MRI在不均匀场

    公开(公告)号：US20100102811A1

    公开(公告)日：2010-04-29

    申请号：US11917639

    申请日：2006-06-16

    申请人： Vasiliki Demas ,  Alexander Pines ,  Rachel W. Martin ,  John Franck ,  Jeffrey A. Reimer

    发明人： Vasiliki Demas ,  Alexander Pines ,  Rachel W. Martin ,  John Franck ,  Jeffrey A. Reimer

    IPC分类号： G01R33/48 ,  G01R23/00

    CPC分类号： G01R33/4833 ,  G01N24/084 ,  G01R33/3808 ,  G01R33/445 ,  G01R33/485 ,  G01R33/56563

    摘要： A method for locally creating effectively homogeneous or “clean” magnetic field gradients (of high uniformity) for imaging (with NMR, MRI, or spectroscopic MRI) both in in-situ and ex-situ systems with high degrees of inhomogeneous field strength. The method of imaging comprises: a) providing a functional approximation of an inhomogeneous static magnetic field strength B0 (r) at a spatial position r; b) providing a temporal functional approximation of Gshim(t) with i basis functions and j variables for each basis function, resulting in vij variables; c) providing a measured value Ω, which is an temporally accumulated dephasing due to the inhomogeneities of B0 (r); and d) minimizing a difference in the local dephasing angle (I) by varying the vij variables to form a set of minimized vij variables. The method requires calibration of the static fields prior to minimization, but may thereafter he implemented without such calibration, may he used in open or closed systems, and potentially portable systems.

    摘要翻译： 在具有高度不均匀场强的原位和非原位系统中，用于局部创建有效均匀或“清洁”磁场梯度（高均匀度））用于成像（使用NMR，MRI或光谱MRI）的方法。 成像方法包括：a）在空间位置r处提供非均匀静态磁场强度B0（r）的函数近似值; b）提供Gshim（t）的时间函数近似与i基函数和每个基函数的j变量，导致vij变量; c）提供由于B0（r）的不均匀性而导致的时间累积去相位的测量值＆amp; 以及d）通过改变vij变量来最小化局部相移角（I）的差异以形成一组最小化的vij变量。 该方法需要在最小化之前对静态场进行校准，然后可以在不进行这种校准的情况下进行实施，可以在开放或封闭的系统以及潜在的便携式系统中使用。