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公开(公告)号：US20180267061A1
公开(公告)日：2018-09-20
申请号：US15915566
申请日：2018-03-08
IPC分类号： G01N33/68 , G01N33/50 , G01N33/543 , G01N33/535 , G01N33/566 , C07K14/78
CPC分类号： G01N33/6887 , A61K38/00 , C07K14/78 , G01N33/5029 , G01N33/5044 , G01N33/5082 , G01N33/535 , G01N33/54306 , G01N33/566 , G01N33/57488 , G01N2333/78 , G01N2800/10 , G01N2800/52 , G01N2800/60
摘要： The present invention provides methods for determining bone growth velocity comprising: (a) measuring an amount of a collagen X marker in a sample obtained from a subject in need thereof; and (b) comparing the amount of collagen X marker measured in step (a) with a collagen X marker standard curve, wherein the amount of collagen X marker is measured using at least two reagents. In an embodiment, there is at least one capture reagent and at least one detection reagent. In a preferred embodiment for measuring CXM, the capture reagent is the aptamer SOMA1 and the detection reagent is the monoclonal antibody mAb X34. The present invention further provides methods for treating diseases, disorders or conditions comprising receiving an identification of an amount of CXM in a sample, wherein the amount of CXM has been identified using a combination of SOMA1 and mAb X34 as CXM-binding reagents, and administering a treatment in light of the amount of CXM in the sample.
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公开(公告)号：US20200378990A1
公开(公告)日：2020-12-03
申请号：US16990052
申请日：2020-08-11
IPC分类号： G01N33/68 , G01N33/50 , G01N33/543 , G01N33/566 , C07K14/78 , G01N33/535 , G01N33/574
摘要： The present invention provides methods for determining bone growth velocity comprising: (a) measuring an amount of a collagen X marker in a sample obtained from a subject in need thereof; and (b) comparing the amount of collagen X marker measured in step (a) with a collagen X marker standard curve, wherein the amount of collagen X marker is measured using at least two reagents. In an embodiment, there is at least one capture reagent and at least one detection reagent. In a preferred embodiment for measuring CXM, the capture reagent is the aptamer SOMA1 and the detection reagent is the monoclonal antibody mAb X34. The present invention further provides methods for treating diseases, disorders or conditions comprising receiving an identification of an amount of CXM in a sample, wherein the amount of CXM has been identified using a combination of SOMA1 and mAb X34 as CXM-binding reagents, and administering a treatment in light of the amount of CXM in the sample.
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公开(公告)号：US20230349921A1
公开(公告)日：2023-11-02
申请号：US18173604
申请日：2023-02-23
IPC分类号： G01N33/68 , G01N33/50 , G01N33/543 , G01N33/566 , C07K14/78 , G01N33/535 , G01N33/574
CPC分类号： G01N33/6887 , C07K14/78 , G01N33/5029 , G01N33/5044 , G01N33/5082 , G01N33/535 , G01N33/54306 , G01N33/566 , G01N33/57488 , A61K38/00 , G01N2800/10 , G01N2800/52 , G01N2800/60
摘要： The present invention provides methods for determining bone growth velocity comprising: (a) measuring an amount of a collagen X marker in a sample obtained from a subject in need thereof; and (b) comparing the amount of collagen X marker measured in step (a) with a collagen X marker standard curve, wherein the amount of collagen X marker is measured using at least two reagents. In an embodiment, there is at least one capture reagent and at least one detection reagent. In a preferred embodiment for measuring CXM, the capture reagent is the aptamer SOMA1 and the detection reagent is the monoclonal antibody mAb X34. The present invention further provides methods for treating diseases, disorders or conditions comprising receiving an identification of an amount of CXM in a sample, wherein the amount of CXM has been identified using a combination of SOMA1 and mAb X34 as CXM-binding reagents, and administering a treatment in light of the amount of CXM in the sample.
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公开(公告)号：US20220065870A1
公开(公告)日：2022-03-03
申请号：US17524166
申请日：2021-11-11
IPC分类号： G01N33/68 , G01N33/50 , G01N33/543 , G01N33/566 , C07K14/78 , G01N33/535 , G01N33/574
摘要： The present invention provides methods for determining bone growth velocity comprising: (a) measuring an amount of a collagen X marker in a sample obtained from a subject in need thereof; and (b) comparing the amount of collagen X marker measured in step (a) with a collagen X marker standard curve, wherein the amount of collagen X marker is measured using at least two reagents. In an embodiment, there is at least one capture reagent and at least one detection reagent. In a preferred embodiment for measuring CXM, the capture reagent is the aptamer SOMA1 and the detection reagent is the monoclonal antibody mAb X34. The present invention further provides methods for treating diseases, disorders or conditions comprising receiving an identification of an amount of CXM in a sample, wherein the amount of CXM has been identified using a combination of SOMA1 and mAb X34 as CXM-binding reagents, and administering a treatment in light of the amount of CXM in the sample.
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公开(公告)号：US20210223263A1
公开(公告)日：2021-07-22
申请号：US17215629
申请日：2021-03-29
IPC分类号： G01N33/68 , G01N33/50 , G01N33/543 , G01N33/566 , C07K14/78 , G01N33/535 , G01N33/574
摘要： The present invention provides methods for determining bone growth velocity comprising: (a) measuring an amount of a collagen X marker in a sample obtained from a subject in need thereof; and (b) comparing the amount of collagen X marker measured in step (a) with a collagen X marker standard curve, wherein the amount of collagen X marker is measured using at least two reagents. In an embodiment, there is at least one capture reagent and at least one detection reagent. In a preferred embodiment for measuring CXM, the capture reagent is the aptamer SOMA1 and the detection reagent is the monoclonal antibody mAb X34. The present invention further provides methods for treating diseases, disorders or conditions comprising receiving an identification of an amount of CXM in a sample, wherein the amount of CXM has been identified using a combination of SOMA1 and mAb X34 as CXM-binding reagents, and administering a treatment in light of the amount of CXM in the sample.
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