公开(公告)号：US20060147425A1

公开(公告)日：2006-07-06

申请号：US10531425

申请日：2003-10-15

申请人： Michel Rathbone ,  Shucui Jiang ,  Jian Wang ,  Pamela Middlemiss ,  Mohammad Khan

发明人： Michel Rathbone ,  Shucui Jiang ,  Jian Wang ,  Pamela Middlemiss ,  Mohammad Khan

IPC分类号： C12N5/08 ,  A61K35/30

CPC分类号： A61K35/30

摘要： Methods of promoting functional regeneration of injured nerve fibers are described. The methods involve administering enteric glial cells to an animal with a nerve injury or neurodegenerative disease. The method is also useful in inducing formation of a blood-brain barrier in the nervous system.

摘要翻译： 描述了促进受损神经纤维功能再生的方法。 所述方法涉及将神经胶质细胞给予具有神经损伤或神经变性疾病的动物。 该方法还可用于诱导神经系统中血脑屏障的形成。

公开(公告)号：US20110014694A1

公开(公告)日：2011-01-20

申请号：US12934349

申请日：2009-04-01

申请人： Shucui Jiang ,  Michel Rathbone

发明人： Shucui Jiang ,  Michel Rathbone

IPC分类号： C12N5/071

CPC分类号： A61K35/38

摘要： Methods of reducing tissue damage in the nervous system are disclosed. The methods involved administering enteric glial cells to an animal with a nerve injury. Methods of improving locomotor function in animal with a nerve injury are also disclosed.

摘要翻译： 公开了减少神经系统中的组织损伤的方法。 所述方法涉及将神经胶质细胞施用于具有神经损伤的动物。 还公开了改善动物神经损伤的运动功能的方法。

公开(公告)号：US20050234105A1

公开(公告)日：2005-10-20

申请号：US11079366

申请日：2005-03-14

申请人： Craig Smith ,  Michel Rathbone ,  Margaret Petty ,  David Rampe

发明人： Craig Smith ,  Michel Rathbone ,  Margaret Petty ,  David Rampe

IPC分类号： C07D401/12 ,  A61K20060101 ,  A61K31/4439 ,  A61P3/00 ,  A61P9/00 ,  A61P13/00 ,  A61P13/10 ,  A61P17/02 ,  A61P19/02 ,  A61P25/00 ,  A61P25/02 ,  A61P25/28 ,  A61P27/02 ,  A61P29/00 ,  A61P35/00

CPC分类号： A61K31/4439 ,  Y10S514/903

摘要： N-(Pyridinyl)-1H-indol-1-amines of formula I provide a unique combination of blocking properties for both the potassium and sodium channels. These compounds are useful for the treatment of Demyelinating Diseases and Conditions such as Multiple Sclerosis, Spinal Cord Injury, Traumatic Brain Injury and Stroke. The compounds are also useful for Stroke Rehabilitation, the treatment of Bladder Irritation and Dysfunction, and the treatment of Neuropathic Pain and Chemokine-Induced Pain.

摘要翻译： 式I的N-（吡啶基）-1H-吲哚-1-胺提供钾和钠通道的阻断性质的独特组合。 这些化合物可用于治疗脱髓鞘疾病和病症如多发性硬化，脊髓损伤，创伤性脑损伤和中风。 这些化合物也可用于中风康复，膀胱刺激和功能障碍的治疗，以及治疗神经性疼痛和趋化因子诱导的疼痛。

公开(公告)号：US20050159456A1

公开(公告)日：2005-07-21

申请号：US11079327

申请日：2005-03-14

申请人： Craig Smith ,  Michel Rathbone ,  Margaret Petty ,  David Rampe

发明人： Craig Smith ,  Michel Rathbone ,  Margaret Petty ,  David Rampe

IPC分类号： C07D401/12 ,  A61K20060101 ,  A61K31/4439 ,  A61P3/00 ,  A61P9/00 ,  A61P13/00 ,  A61P13/10 ,  A61P17/02 ,  A61P19/02 ,  A61P25/00 ,  A61P25/02 ,  A61P25/28 ,  A61P27/02 ,  A61P29/00 ,  A61P35/00

CPC分类号： A61K31/4439 ,  Y10S514/903

摘要： N-(Pyridinyl)-1H-indol-1-amines of formula I provide a unique combination of blocking properties for both the potassium and sodium channels. These compounds are useful for the treatment of Demyelinating Diseases and Conditions such as Multiple Sclerosis, Spinal Cord Injury, Traumatic Brain Injury and Stroke. The compounds are also useful for Stroke Rehabilitation, the treatment of Bladder Irritation and Dysfunction, and the treatment of Neuropathic Pain and Chemokine-Induced Pain.

公开(公告)号：US20060025452A1

公开(公告)日：2006-02-02

申请号：US11236145

申请日：2005-09-27

申请人： Craig Smith ,  Michel Rathbone ,  Margaret Petty ,  David Rampe

发明人： Craig Smith ,  Michel Rathbone ,  Margaret Petty ,  David Rampe

IPC分类号： A61K31/4439

CPC分类号： A61K31/4439 ,  Y10S514/903

摘要： N-(Pyridinyl)-1H-indol-1-amines of formula I provide a unique combination of blocking properties for both the potassium and sodium channels. These compounds are useful for the treatment of Demyelinating Diseases and Conditions such as Multiple Sclerosis, Spinal Cord Injury, Traumatic Brain Injury and Stroke. The compounds are also useful for Stroke Rehabilitation, the treatment of Bladder Irritation and Dysfunction, and the treatment of Neuropathic Pain and Chemokine-Induced Pain.

公开(公告)号：US20060063788A1

公开(公告)日：2006-03-23

申请号：US11240587

申请日：2005-09-29

申请人： Alvin Glasky ,  Michel Rathbone

发明人： Alvin Glasky ,  Michel Rathbone

IPC分类号： A61K31/522

CPC分类号： A61K31/7076 ,  A61K31/52 ,  A61K31/522 ,  A61K31/708

摘要： Disclosed herein are methods and associated compositions and medicaments directed generally to the control of cellular and neural activity and for selectively and controllably inducing the in vivo genetic expression of one or more naturally occurring genetically encoded molecules in mammals. More particularly, the present invention selectively activates or derepresses genes encoding for specific naturally occurring molecules such as proteins or neurotrophic factors and induces the endogenous production of such naturally occurring compounds through the administration of carbon monoxide dependent guanylyl cyclase modulating purine derivatives. The methods of the present invention may be used to affect a variety of cellular and neurological functions and activities and to therapeutically or prophylactically treat a wide variety of neurodegenerative, neurological, cellular, and physiological disorders.