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    FOCAL CAVITATION SIGNAL MEASUREMENT
    2.
    发明申请
    FOCAL CAVITATION SIGNAL MEASUREMENT 审中-公开

    公开(公告)号：US20190083065A1

    公开(公告)日：2019-03-21

    申请号：US15708214

    申请日：2017-09-19

    申请人： Shuki VITEK ,  Yoav LEVY

    发明人： Shuki VITEK ,  Yoav LEVY

    IPC分类号： A61B8/00 ,  A61B8/08

    摘要： Various approaches for detecting cavitation signals from a target region of a patient during a focused ultrasound procedure include an ultrasound transducer; an imaging device for acquiring physiological characteristics of multiple anatomical regions through which the cavitation signals from the target region travel; a controller configured to select one or more of the anatomical regions based at least in part on the physiological characteristics thereof and map the selected anatomical region(s) to one or more corresponding skin regions; and one or more cavitation detection devices attached to the corresponding skin region(s).

    ULTRASOUND FOCUSING USING A CROSS-POINT SWITCH MATRIX
    3.
    发明申请
    ULTRASOUND FOCUSING USING A CROSS-POINT SWITCH MATRIX 审中-公开

    公开(公告)号：US20180360420A1

    公开(公告)日：2018-12-20

    申请号：US15627922

    申请日：2017-06-20

    申请人： Kobi VORTMAN ,  Shuki VITEK ,  Yoav LEVY

    发明人： Kobi VORTMAN ,  Shuki VITEK ,  Yoav LEVY

    IPC分类号： A61B8/00 ,  A61B5/01 ,  A61B5/055 ,  A61N7/02 ,  G01S7/52

    摘要： A system for delivering ultrasound energy to an internal anatomical target includes an ultrasound transducer having multiple transducer elements collectively operable as a phased array; multiple driver circuits, each being connected to at least one of the transducer elements; multiple phase circuits; a switch matrix selectably coupling the driver circuits to the phase circuits; and a controller configured for (i) receiving as input a target average intensity level and/or an energy level energy to be applied to the target and/or a temperature level in target, (ii) identifying multiple sets of the transducer elements, each of the sets corresponding to multiple transducer elements for shaping and/or focusing, as a phased array, ultrasound energy at the target across tissue intervening between the target and the ultrasound transducer, and (iii) sequentially operating the transducer-element sets to apply and maintain the target average energy level at the target. In various embodiments, the controller operates each of the transducer element sets in accordance with a pulse-width modulation pattern having a duty cycle selected to achieve the target average intensity level, energy level, and/or temperature level at the target in accordance with a time constant of the target tissue.

    ULTRASOUND FOCUSING IN DYNAMICALLY CHANGING MEDIA
    5.
    发明申请
    ULTRASOUND FOCUSING IN DYNAMICALLY CHANGING MEDIA 审中-公开

    公开(公告)号：US20190175954A1

    公开(公告)日：2019-06-13

    申请号：US15837365

    申请日：2017-12-11

    申请人： Yoav LEVY ,  Eyal ZADICARIO ,  Shuki VITEK ,  Javier GRINFELD ,  Ohad SILBIGER

    发明人： Yoav LEVY ,  Eyal ZADICARIO ,  Shuki VITEK ,  Javier GRINFELD ,  Ohad SILBIGER

    IPC分类号： A61N7/02

    摘要： Various approaches to generating and maintaining an ultrasound focus at a target region include configuring a controller to cause transmission of treatment ultrasound pulses from a transducer having multiple transducer elements; cause the transducer to transmit focusing ultrasound pulses to the target region and generate an acoustic reflector therein; measure reflections of the focusing ultrasound pulses from the acoustic reflector; based at least in part on the measured reflections, adjust a parameter value associated with one or more transducer elements so as to maintain and/or improve the ultrasound focus at the target region.

    SIMULATION-BASED DRUG TREATMENT PLANNING
    7.
    发明申请
    SIMULATION-BASED DRUG TREATMENT PLANNING 审中-公开

    公开(公告)号：US20200171327A1

    公开(公告)日：2020-06-04

    申请号：US16622050

    申请日：2018-06-29

    申请人： Yoav LEVY ,  Rafi DE PICCIOTTO ,  Javier GRINFELD ,  Eyal ZADICARIO

    发明人： Yoav LEVY ,  Rafi DE PICCIOTTO ,  Javier GRINFELD ,  Eyal ZADICARIO

    IPC分类号： A61N5/10 ,  A61B34/10 ,  A61N7/02 ,  A61B5/00

    摘要： Various approaches for computationally generating a protocol for treatment of one or more target BBB regions within a tissue region of interest using a source of focused ultrasound include specifying (i) settings of sonication parameters for applying one or more sequence of sonications to the target BBB region using the source of focused ultrasound and (ii) a characteristic of microbubbles selected to be administered into the target BBB region; electronically simulating treatment in accordance with the protocol at least in part by computationally executing the sequence(s) of sonications and computationally administering the microbubbles having the characteristic; and computationally predicting a tissue disruption effect of the target BBB region resulting from the treatment.

    SYSTEMS AND METHODS FOR CORRECTING MEASUREMENT ARTIFACTS IN MR THERMOMETRY
    8.
    发明申请
    SYSTEMS AND METHODS FOR CORRECTING MEASUREMENT ARTIFACTS IN MR THERMOMETRY 审中-公开

    公开(公告)号：US20200166593A1

    公开(公告)日：2020-05-28

    申请号：US16202558

    申请日：2018-11-28

    申请人： Shahar RINOTT ,  Yoav LEVY

    发明人： Shahar RINOTT ,  Yoav LEVY

    IPC分类号： G01R33/48 ,  G01R33/54

    摘要： Systems and methods for performing magnetic resonance (MR) thermometry include a magnetic resonance imaging (MRI) unit and a controller in communication with the MRI unit and configured to cause the MRI unit to acquire one or more baseline phase images of an imaging region and one or more treatment phase images of the imaging region subsequent to a temperature change of a subregion within the imaging region, electronically generate a thermal map pixelwise indicating the temperature change of the subregion based at least in part on the acquired baseline phase image and treatment phase image, computationally predict the temperature change of the subregion based at least in part on energy deposited in the subregion during treatment without reference to the generated thermal map, and determine whether the thermal map is inaccurate based at least in part on the temperature change of the subregion indicated by the thermal map and the predicted temperature change of the subregion.

    VARIABLE-BANDWIDTH TRANSDUCERS WITH ASYMMETRIC FEATURES
    9.
    发明公开
    VARIABLE-BANDWIDTH TRANSDUCERS WITH ASYMMETRIC FEATURES 审中-公开

    公开(公告)号：US20230145064A1

    公开(公告)日：2023-05-11

    申请号：US17520068

    申请日：2021-11-05

    申请人： Kobi VORTMAN ,  Yoav LEVY ,  Oleg PRUS

    发明人： Kobi VORTMAN ,  Yoav LEVY ,  Oleg PRUS

    IPC分类号： A61B8/00 ,  A61B8/08 ,  B06B1/02

    CPC分类号： A61B8/4494 ,  A61B8/0858 ,  A61B8/546 ,  B06B1/0207 ,  B06B2201/76

    摘要： Transducer elements have one or more asymmetric features that give rise to multiple natural resonance frequencies. The feature(s) can be discrete (e.g., steps, bars, or gemstone-like facets) or continuous across one or more dimensions of the transducer element (e.g., a triangular prism). A transducer element can be driven at more than one resonance frequency; multiple frequencies will excite more than one feature in parallel, each producing an output emission with a characteristic frequency and phase. An optimal frequency—i.e., one that maximizes the peak acoustic intensity or acoustic power at the target—within a certain frequency range may be determined, and a plurality of asymmetric transducer elements may be driven at a center frequency that coincides with or is close to this optimal frequency.

    SYSTEMS AND METHODS FOR REGULATING MICROBUBBLES IN ULTRASOUND PROCEDURES
    10.
    发明申请
    SYSTEMS AND METHODS FOR REGULATING MICROBUBBLES IN ULTRASOUND PROCEDURES 审中-公开

    公开(公告)号：US20200323515A1

    公开(公告)日：2020-10-15

    申请号：US16378945

    申请日：2019-04-09

    申请人： Yoav LEVY

    发明人： Yoav LEVY

    IPC分类号： A61B8/08 ,  G01S15/89 ,  A61N7/02

    摘要： Various approaches for regulating microbubbles in a treatment procedure for a target include generating a tissue-sensitivity map including multiple regions, at least one of the regions being outside the target region, the tissue-sensitivity map assigning, to each of the regions, a sensitivity level indicative of tissue sensitivity to the interaction between the microbubbles and an acoustic beam; select one or more interaction regions based at least in part on the tissue-sensitivity map; and activating the ultrasound transducer so as to generate the acoustic beam for interacting with the microbubbles in the selection interaction region(s) in the tissue-sensitivity map, thereby indirectly changing a characteristic of the microbubbles at the target region.