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公开(公告)号：US20110028535A1
公开(公告)日：2011-02-03
申请号：US12904054
申请日：2010-10-13
申请人： Shunichiro KUBOTA , Masaaki Terada , Takahiro Ochiya , Hiroshi Itoh , Masayasu Furuse , Akihiko Sano , Shunji Nagahara
发明人： Shunichiro KUBOTA , Masaaki Terada , Takahiro Ochiya , Hiroshi Itoh , Masayasu Furuse , Akihiko Sano , Shunji Nagahara
IPC分类号： A61K48/00
CPC分类号： A61K9/0024 , A61K9/0019 , A61K9/127 , A61K9/19 , A61K9/2063 , A61K9/7007 , A61K31/7105 , A61K31/711 , A61K47/42 , A61K48/00 , A61K48/0008
摘要： Preparations for transferring efficiently oligonucleotides necessary in antisense therapy or the like into animal cells so as to be useful in treatment for various diseases, which comprises a collagen as an essential component are provided.
摘要翻译： 提供将反义治疗等中必需的寡核苷酸有效转移到动物细胞中以便可用于治疗包括胶原蛋白作为必需成分的各种疾病的制剂。
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公开(公告)号：US20090258933A1
公开(公告)日：2009-10-15
申请号：US12486703
申请日：2009-06-17
申请人： Shunichiro KUBOTA , Masaaki Terada , Takahiro Ochiya , Hiroshi Itoh , Masayasu Furuse , Akihiko Sano , Shunji Nagahara
发明人： Shunichiro KUBOTA , Masaaki Terada , Takahiro Ochiya , Hiroshi Itoh , Masayasu Furuse , Akihiko Sano , Shunji Nagahara
IPC分类号： A61K31/7088
CPC分类号： A61K9/0024 , A61K9/0019 , A61K9/127 , A61K9/19 , A61K9/2063 , A61K9/7007 , A61K31/7105 , A61K31/711 , A61K47/42 , A61K48/00 , A61K48/0008
摘要： Preparations for transferring efficiently oligonucleotides necessary in antisense therapy or the like into animal cells so as to be useful in treatment for various diseases, which comprises a collagen as an essential component are provided.
摘要翻译： 提供将反义治疗等中必需的寡核苷酸有效转移到动物细胞中以便可用于治疗包括胶原蛋白作为必需成分的各种疾病的制剂。
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公开(公告)号：US20100081202A1
公开(公告)日：2010-04-01
申请号：US12554846
申请日：2009-09-04
申请人： Masaaki Terada , Takahiro Ochiya , Yu Aso , Kimi Honma , Akihiko Sano , Shunji Nagahara
发明人： Masaaki Terada , Takahiro Ochiya , Yu Aso , Kimi Honma , Akihiko Sano , Shunji Nagahara
IPC分类号： C12N15/63
CPC分类号： A61K48/0008 , A61K47/6435 , A61K48/00 , C12N15/87
摘要： Means for transferring efficiently a desired nucleic acid into a cell is provided.The present invention comprises using a complex comprising a collagen or a collagen derivative, and a desired nucleic acid.
摘要翻译： 提供了将期望的核酸有效转移到细胞中的方法。 本发明包括使用包含胶原蛋白或胶原衍生物和所需核酸的复合物。
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公开(公告)号：US08742091B2
公开(公告)日：2014-06-03
申请号：US10481511
申请日：2002-06-20
申请人： Masaaki Terada , Takahiro Ochiya , Yu Aso , Kimi Honma , Akihiko Sano , Shunji Nagahara
发明人： Masaaki Terada , Takahiro Ochiya , Yu Aso , Kimi Honma , Akihiko Sano , Shunji Nagahara
CPC分类号： A61K48/0008 , A61K47/6435 , A61K48/00 , C12N15/87
摘要： Means for transferring efficiently a desired nucleic acid into a cell is provided.The present invention comprises using a complex comprising a collagen or a collagen derivative, and a desired nucleic acid.
摘要翻译： 提供了将期望的核酸有效转移到细胞中的方法。 本发明包括使用包含胶原蛋白或胶原衍生物和所需核酸的复合物。
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公开(公告)号：US07052875B1
公开(公告)日：2006-05-30
申请号：US09701013
申请日：1999-05-19
IPC分类号： C12P19/34 , A61K38/17 , C07H21/02 , C07C59/255 , C07C59/265
CPC分类号： A61K48/0025 , A61K48/0008 , A61K48/0091
摘要： The invention is directed to the retention of the stability of formulations useful for a gene therapy during the preparation and preservation. In the invention, at least one saccharide and/or at least one non-hydrophobic amino acid and/or at least one organic acid having two or more carboxyl groups except amino acids, or a collagen or a gelatin and at least one amino acid are added to a gene formulation.
摘要翻译： 本发明涉及在制备和保存期间保留用于基因治疗的制剂的稳定性。 在本发明中，至少一种糖和/或至少一种非疏水性氨基酸和/或至少一种除氨基酸以外具有两个或多个羧基的有机酸，或胶原或明胶和至少一种氨基酸 添加到基因制剂中。
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公开(公告)号：US20110217366A1
公开(公告)日：2011-09-08
申请号：US13109949
申请日：2011-05-17
申请人： Keiji FUJIOKA , Akihiko Sano , Shunji Nagahara , Malcolm Roy Brandon , Andrew Donald Nash , Shari Lofthouse
发明人： Keiji FUJIOKA , Akihiko Sano , Shunji Nagahara , Malcolm Roy Brandon , Andrew Donald Nash , Shari Lofthouse
IPC分类号： A61K39/12 , A61K39/00 , A61K39/02 , A61K39/002 , A61K9/00 , A61K9/127 , C07K16/00 , A61P31/12 , A61P31/04 , A61P31/00 , A61P33/00 , A61P37/04
CPC分类号： A61K39/39 , A61K9/0024 , A61K9/0092 , A61K9/70 , A61K47/42
摘要： The present invention provides an immunopotentiating composition which comprises an antigen or antigen-inducing substance, and a carrier comprising a biocompatible material for effectively increasing an immune response derived from an antigen. The present invention further provides a method of producing an antibody by administering said immunopotentiating composition to a mammal or bird, thereby modulating the immune response in said mammal or bird and recovering the antibody produced.
摘要翻译： 本发明提供一种免疫增强组合物，其包含抗原或抗原诱导物质，和包含生物相容性物质的载体，用于有效增加源自抗原的免疫应答。 本发明进一步提供了通过向哺乳动物或鸟施用所述免疫增强组合物从而调节所述哺乳动物或鸟类中的免疫应答并回收产生的抗体来产生抗体的方法。
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公开(公告)号：US20060258602A1
公开(公告)日：2006-11-16
申请号：US10527597
申请日：2003-09-19
申请人： Yukio Ando , Masaaki Nakamura , Shunji Nagahara
发明人： Yukio Ando , Masaaki Nakamura , Shunji Nagahara
IPC分类号： A61K48/00
CPC分类号： C12N15/87 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A61K31/7088 , A61K47/42 , A61K48/0041 , A61K48/005 , C12N15/907
摘要： It is intended to provide a preparation whereby an oligonucleotide is efficiently transferred into a cell and the localization thereof in nucleus is promoted, a preparation for facilitating the conversion of the base sequence of a target genomic gene, and a preparation for gene therapy. Namely, a preparation for facilitating site-specific gene conversion which comprises at least a collagen and an oligonucleotide for gene conversion; a preparation for site-specific gene therapy which comprises at least a collagen and an oligonucleotide for gene conversion; a method of arbitrarily converting a specific base on a genomic gene in the nucleus of a cell which comprises bringing the above-described preparation for facilitating gene conversion into contact with the cell; and an preparation for facilitating oligonucleotide intranuclear localization which comprises at least a collagen and an oligonucleoitde.
摘要翻译： 旨在提供寡核苷酸被有效地转移到细胞中并促进其在细胞核中的定位的制备，用于促进靶基因组基因的碱基序列的转化的制剂和用于基因治疗的制剂。 即，用于促进位点特异性基因转化的制剂，其至少包含用于基因转化的胶原和寡核苷酸; 用于特异性基因治疗的制剂，其至少包含用于基因转化的胶原和寡核苷酸; 任意转化细胞核中的基因组基因的特定碱基的方法，其包括使上述促进基因转化的制剂与细胞接触; 以及促进寡核苷酸核内定位的制剂，其至少包含胶原和寡核苷酸。
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