公开(公告)号：US08242142B2

公开(公告)日：2012-08-14

申请号：US12543480

申请日：2009-08-18

申请人： Shuo Lin ,  Zhen Yang

发明人： Shuo Lin ,  Zhen Yang

IPC分类号： A61K31/4406 ,  C07D409/12

CPC分类号： C07D409/04

摘要： Compounds having the formula I, their methods of synthesis, and pharmaceutically acceptable salts of certain of them are provided in which the variables have the definitions described herein. Compositions including the compounds having the formula I-A in which the variables have the definitions described herein, and methods of using the compositions for the treatment of certain diseases mediated by the up-regulation of Smo are also disclosed.

摘要翻译： 提供了具有式I的化合物，其合成方法及其某些药学上可接受的盐，其中变量具有本文所述的定义。 还公开了包括具有式I-A的化合物的组合物，其中变量具有本文所述的定义，以及使用该组合物治疗由上调Smo介导的某些疾病的方法。

公开(公告)号：US20100048637A1

公开(公告)日：2010-02-25

申请号：US12543480

申请日：2009-08-18

申请人： Shuo Lin ,  Zhen Yang

发明人： Shuo Lin ,  Zhen Yang

IPC分类号： A61K31/4436 ,  C07D409/02 ,  C07K14/00 ,  A61P35/00

CPC分类号： C07D409/04

摘要： Compounds having the formula I, their methods of synthesis, and pharmaceutically acceptable salts of certain of them are provided in which the variables have the definitions described herein. Compositions including the compounds having the formula I-A in which the variables have the definitions described herein, and methods of using the compositions for the treatment of certain diseases mediated by the up-regulation of Smo are also disclosed.

摘要翻译： 提供了具有式I的化合物，其合成方法及其某些药学上可接受的盐，其中变量具有本文所述的定义。 还公开了包括具有式I-A的化合物的组合物，其中变量具有本文所述的定义，以及使用该组合物治疗由上调Smo介导的某些疾病的方法。

公开(公告)号：US20190394347A1

公开(公告)日：2019-12-26

申请号：US16481359

申请日：2017-02-15

申请人： Jian-Qun ZHANG ,  Fei ZHANG ,  Zhen YANG ,  Hewlett-Packard Development Company, L.P.

发明人： Jian-Qun Zhang ,  Fei Zhang ,  Zhen Yang

IPC分类号： H04N1/00 ,  H04N1/32

摘要： Examples disclosed herein relate to a protected electronic communication method comprising assigning a protected electronic communication to a data element, wherein the protected electronic communication comprises a plurality of identifier segments, receiving a request for the data element to be included in an analytics report, determining, according to the protected electronic communication, whether the data element is permitted to be included in the analytics report, and in response to determining that the data element is permitted to be included in the analytics report, providing the data element for use in the analytics report.

公开(公告)号：US08676811B2

公开(公告)日：2014-03-18

申请号：US12594930

申请日：2007-08-28

申请人： Lei Pan ,  Yuanhu Yao ,  Zhen Yang ,  Tianji Zhang

发明人： Lei Pan ,  Yuanhu Yao ,  Zhen Yang ,  Tianji Zhang

IPC分类号： G06F17/30

CPC分类号： G06F17/3097 ,  G06F17/3064 ,  G06F17/30699

摘要： Provided is a method of generating updating parameters. The method obtains search keywords used by users within a predetermined time period; counts the search keywords to obtain primary keywords, related keywords, co-search frequencies of each primary keyword and the respective related keywords being searched together, and search frequencies of the primary keywords being searched alone; computes first feature values based on the search frequencies of the primary keywords being searched alone; and then computes second feature values based on the first feature values and the co-search frequencies of the primary keywords and the respective related keywords. The second feature values serve as updating parameters for determining displaying modes of the related keywords. An apparatus of generating updating parameters, and a method and an apparatus of displaying related keywords according to the updating parameters are also provided. The solution keeps abreast with the user trends to allow a better user experience and improve computing performance and efficiency. For a service provider, no special secret algorithm is needed, and the operation is easy with a low development cost.

公开(公告)号：US08639720B2

公开(公告)日：2014-01-28

申请号：US12970485

申请日：2010-12-16

申请人： Peng Gao ,  Shaw-Ben Shi ,  Zhen Yang ,  Yue Yu

发明人： Peng Gao ,  Shaw-Ben Shi ,  Zhen Yang ,  Yue Yu

IPC分类号： G06F17/30 ,  G06F7/00

CPC分类号： G06F17/30

摘要： A computer implemented method for accessing data begins with receipt of a data access request. In response to determining that the requested data needs to be acquired in real time from an original data source, the processor acquires and stores that data. In response to determining that the data cannot be acquired in real time from the data source, the processor acquires the data from a configuration management database in which the requested data was previously stored.

摘要翻译： 用于访问数据的计算机实现的方法从接收到数据访问请求开始。 响应于确定需要从原始数据源实时获取所请求的数据，处理器获取并存储该数据。 响应于确定不能从数据源实时获取数据，处理器从配置管理数据库中获取先前存储了请求的数据的数据。

公开(公告)号：US08048889B2

公开(公告)日：2011-11-01

申请号：US11093846

申请日：2005-03-29

申请人： Bin Xu ,  Qiang Zhu ,  Hyun-Joon Cho ,  Reza Fathi ,  Zhen Yang ,  Anthony Sandrasagra ,  Yixin Liu

发明人： Bin Xu ,  Qiang Zhu ,  Hyun-Joon Cho ,  Reza Fathi ,  Zhen Yang ,  Anthony Sandrasagra ,  Yixin Liu

IPC分类号： A61K31/505 ,  A61K31/35 ,  A61K31/425 ,  A01N43/54 ,  C07D401/00 ,  C07D239/02 ,  C07D277/00 ,  C07D311/02

CPC分类号： A61K31/366 ,  A61K31/4025 ,  A61K31/4433 ,  A61K31/4709 ,  A61K31/675

摘要： The present invention relates to 3,4-disubstituted coumarin and quinolone derivatives and processes for their preparation. The invention also related to methods for treating infection of Hepatitis C virus by administering a 3,4-disubstituted coumarin or quinolone derivative.

摘要翻译： 本发明涉及3,4-二取代香豆素和喹诺酮衍生物及其制备方法。 本发明还涉及通过施用3,4-二取代香豆素或喹诺酮衍生物来治疗丙型肝炎病毒感染的方法。

公开(公告)号：US07923004B2

公开(公告)日：2011-04-12

申请号：US11974744

申请日：2007-10-15

申请人： Guolin Li ,  Reza Fathi ,  Zhen Yang ,  Yun Liao ,  Qiang Zhu ,  Angela Lam ,  Anthony Sandrasagra ,  Kenneth Nawoschik ,  Hyun-Joon Cho ,  Jie Cao ,  Wu Ruoqiu ,  C. Richard Wobbe ,  Yixin Liu

发明人： Guolin Li ,  Reza Fathi ,  Zhen Yang ,  Yun Liao ,  Qiang Zhu ,  Angela Lam ,  Anthony Sandrasagra ,  Kenneth Nawoschik ,  Hyun-Joon Cho ,  Jie Cao ,  Wu Ruoqiu ,  C. Richard Wobbe ,  Yixin Liu

IPC分类号： A61K38/21

CPC分类号： C07D401/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12

摘要： Aryl substituted pyrazole derivatives are provided, as well as processes for their preparation. The invention also provides compositions and methods for the treatment of HCV by administering a compound of the present invention, alone or in combination with additional antiviral agents, in a therapeutically effective amount.

摘要翻译： 提供了芳基取代的吡唑衍生物，以及其制备方法。 本发明还提供了治疗HCV的组合物和方法，其通过以治疗有效量施用单独或与其它抗病毒剂组合的本发明化合物。

公开(公告)号：US07759194B2

公开(公告)日：2010-07-20

申请号：US12180389

申请日：2008-07-25

申请人： Yi-Peng Chan ,  Sheng-He Huang ,  Zhen Yang

发明人： Yi-Peng Chan ,  Sheng-He Huang ,  Zhen Yang

IPC分类号： H01L27/115

CPC分类号： H01L27/11521 ,  H01L21/28273 ,  H01L27/11206 ,  H01L27/115 ,  H01L27/11519 ,  H01L27/11524 ,  H01L29/42324 ,  H01L29/7883

摘要： An electrically programmable device with embedded EEPROM and method for making thereof. The method includes providing a substrate including a first device region and a second device region, growing a first gate oxide layer in the first device region and the second device region, and forming a first diffusion region in the first device region and a second diffusion region and a third diffusion region in the second device region. Additionally, the method includes implanting a first plurality of ions to form a fourth diffusion region in the first device region and a fifth diffusion region in the second device region. The fourth diffusion region overlaps with the first diffusion region.

摘要翻译： 具有嵌入式EEPROM的电可编程器件及其制造方法。 该方法包括提供包括第一器件区域和第二器件区域的衬底，在第一器件区域和第二器件区域中生长第一栅极氧化物层，以及在第一器件区域中形成第一扩散区域和第二扩散区域 以及第二装置区域中的第三扩散区域。 此外，该方法包括：注入第一多个离子以在第一器件区域中形成第四扩散区域，并在第二器件区域中形成第五扩散区域。 第四扩散区域与第一扩散区域重叠。

公开(公告)号：US20100019308A1

公开(公告)日：2010-01-28

申请号：US12180389

申请日：2008-07-25

申请人： YI-PENG CHAN ,  Sheng-He Huang ,  Zhen Yang

发明人： YI-PENG CHAN ,  Sheng-He Huang ,  Zhen Yang

IPC分类号： H01L27/115 ,  H01L21/8247

CPC分类号： H01L27/11521 ,  H01L21/28273 ,  H01L27/11206 ,  H01L27/115 ,  H01L27/11519 ,  H01L27/11524 ,  H01L29/42324 ,  H01L29/7883

摘要： An electrically programmable device with embedded EEPROM and method for making thereof. The method includes providing a substrate including a first device region and a second device region, growing a first gate oxide layer in the first device region and the second device region, and forming a first diffusion region in the first device region and a second diffusion region and a third diffusion region in the second device region. Additionally, the method includes implanting a first plurality of ions to form a fourth diffusion region in the first device region and a fifth diffusion region in the second device region. The fourth diffusion region overlaps with the first diffusion region.

摘要翻译： 具有嵌入式EEPROM的电可编程器件及其制造方法。 该方法包括提供包括第一器件区域和第二器件区域的衬底，在第一器件区域和第二器件区域中生长第一栅极氧化物层，以及在第一器件区域中形成第一扩散区域和第二扩散区域 以及第二装置区域中的第三扩散区域。 此外，该方法包括：注入第一多个离子以在第一器件区域中形成第四扩散区域，并在第二器件区域中形成第五扩散区域。 第四扩散区域与第一扩散区域重叠。

公开(公告)号：US20080270832A1

公开(公告)日：2008-10-30

申请号：US11790251

申请日：2007-04-24

申请人： Ramandeep Sethi ,  Zhen Yang ,  Tom Whittaker ,  Shoji Kuruvilla

发明人： Ramandeep Sethi ,  Zhen Yang ,  Tom Whittaker ,  Shoji Kuruvilla

IPC分类号： G06F11/07

CPC分类号： G06F11/1443 ,  G06F11/2082 ,  H04L67/1095 ,  H04L69/40

摘要： Systems, methods and computer program products for efficiently re-starting and/or recovering interrupted synchronizations between a client and a server are described herein. A server transmits sync data to a client during a synchronization operation. The sync is interrupted for some reason prior to the client receiving all of the sync data. The client sends to the server a request to re-start the synchronization operation. The request includes information that identifies a point in the sync data that was received by the client prior to interruption of the sync. Such information may include (a) information identifying the last data received by the client prior to interruption of the sync; and/or (b) information identifying the next data needed by the client upon re-start of the sync. Thereafter, the server re-starts the sync by transmitting to the client the sync data starting from said point in said sync data identified by said request.

摘要翻译： 这里描述了用于有效地重新启动和/或恢复客户机和服务器之间的中断的同步的系统，方法和计算机程序产品。 服务器在同步操作期间向客户端发送同步数据。 在客户端接收到所有同步数据之前，由于某种原因，同步被中断。 客户端向服务器发送重新启动同步操作的请求。 该请求包括标识在同步中断之前由客户端接收的同步数据中的点的信息。 这样的信息可以包括（a）在同步中断之前识别客户端接收的最后数据的信息; 和/或（b）识别重新开始同步时客户端所需的下一个数据的信息。 此后，服务器通过向所述客户端发送从所述请求所标识的所述同步数据中的所述点开始的同步数据来重新开始同步。