公开(公告)号：US09744379B2

公开(公告)日：2017-08-29

申请号：US14004504

申请日：2012-03-13

申请人： Shyam Bharat ,  Karl Antonin Bzdusek ,  Parag Jitendra Parikh ,  Camille Elizabeth Noel

发明人： Shyam Bharat ,  Karl Antonin Bzdusek ,  Parag Jitendra Parikh ,  Camille Elizabeth Noel

IPC分类号： A61N5/00 ,  A61N5/10

CPC分类号： A61N5/1037 ,  A61N5/1031 ,  A61N2005/1072

摘要： A treatment planning system (106) for generating patient-specific treatment margins. The system (106) includes one or more processors (142). The processors (142) are programmed to receive a radiation treatment plan (RTP) for irradiating a target (122) over the course of one or more treatment fractions. The RTP including one or more treatment margins around the target (122) and a planned dose distribution for the target (122). The processors (142) are further programmed to receive motion data for at least one of the treatment fractions of the RTP from one or more target surrogates (124), calculate a motion-compensated dose distribution for the target (122) using the motion data and the planned dose distribution, compare the motion-compensated dose distribution to the planned dose distribution, and adjust the treatment margins based on dosimetric differences between the motion-compensated dose distribution and the planned dose distribution.

公开(公告)号：US20140005464A1

公开(公告)日：2014-01-02

申请号：US14004504

申请日：2012-03-13

申请人： Shyam Bharat ,  Karl Antonin Bzdusek ,  Parag Jitendra Parikh ,  Camille Elizabeth Noel

发明人： Shyam Bharat ,  Karl Antonin Bzdusek ,  Parag Jitendra Parikh ,  Camille Elizabeth Noel

IPC分类号： A61N5/10

CPC分类号： A61N5/1037 ,  A61N5/1031 ,  A61N2005/1072

摘要： A treatment planning system (106) for generating patient-specific treatment margins. The system (106) includes one or more processors (142). The processors (142) are programmed to receive a radiation treatment plan (RTP) for irradiating a target (122) over the course of one or more treatment fractions. The RTP including one or more treatment margins around the target (122) and a planned dose distribution for the target (122). The processors (142) are further programmed to receive motion data for at least one of the treatment fractions of the RTP from one or more target surrogates (124), calculate a motion-compensated dose distribution for the target (122) using the motion data and the planned dose distribution, compare the motion-compensated dose distribution to the planned dose distribution, and adjust the treatment margins based on dosimetric differences between the motion-compensated dose distribution and the planned dose distribution.

摘要翻译： 一种用于产生患者特异性治疗边缘的治疗计划系统（106）。 系统（106）包括一个或多个处理器（142）。 处理器（142）被编程为接收用于在一个或多个处理分数的过程中照射目标（122）的放射治疗计划（RTP）。 RTP包括目标周围的一个或多个治疗边缘（122）和目标（122）的计划剂量分布。 处理器（142）还被编程为从一个或多个目标代理（124）接收RTP的处理分数中的至少一个的运动数据，使用运动数据计算目标（122）的运动补偿剂量分布 和计划剂量分布，将运动补偿剂量分布与计划剂量分布进行比较，并根据运动补偿剂量分布与计划剂量分布之间的剂量差异来调整治疗余量。

公开(公告)号：US20100256530A1

公开(公告)日：2010-10-07

申请号：US12416485

申请日：2009-04-01

申请人： Tomy Varghese ,  Shyam Bharat

发明人： Tomy Varghese ,  Shyam Bharat

IPC分类号： A61B5/103 ,  A61B18/18

CPC分类号： A61B18/18 ,  A61B5/0051 ,  A61B5/015 ,  A61B5/441 ,  A61B8/485 ,  A61B18/1815

摘要： Real-time monitoring of tissue ablation is possible by using a vibrating ablation needle coupling lateral shear waves to the tissue. Ultrasonic imaging may characterize the velocity of these shear waves to reveal Young's modulus of the tissue and, at a discontinuity in Young's modulus, a boundary of the ablated lesion reflecting an underlying increase in stiffness of ablated tissue. This technique may be coupled with quasi-static elastography-based ablation monitoring techniques for improved measurement.

摘要翻译： 通过使用振动消融针将横向剪切波耦合到组织，实现对组织消融的实时监测。 超声成像可以表征这些剪切波的速度，以显示组织的杨氏模量，并且在杨氏模量的不连续性处，消融的病变的边界反映消融组织的刚度的潜在增加。 该技术可以与基于准静态弹性成像的消融监测技术相结合，以改进测量。

公开(公告)号：US09259155B2

公开(公告)日：2016-02-16

申请号：US14237227

申请日：2012-07-24

申请人： Shyam Bharat ,  Vijay Parthasarathy

发明人： Shyam Bharat ,  Vijay Parthasarathy

IPC分类号： G01T1/08 ,  A61N5/10 ,  A61B5/00 ,  A61B5/11

CPC分类号： A61B5/0033 ,  A61B5/1126 ,  A61B5/721 ,  A61B2562/0233 ,  A61N5/103 ,  A61N5/1037 ,  A61N5/1038 ,  A61N5/1039 ,  A61N5/1049 ,  A61N5/1071 ,  A61N2005/1051 ,  A61N2005/1072 ,  G01T1/08 ,  G06T2207/30004

摘要： A therapy system (10) includes one or more processors (98, 100). The processors (98, 100) are programmed to receive one or more of: (1) dosimetric data from dosimeters (26, 28, 202, 204, 206, 208, 210, 212) implanted within a patient and/or positioned on a vest (200); and (2) motion data from surrogates (18, 20, 22, 24) implanted within the patient. Based on the motion data, a current location and/or shape of a surrogate (18, 20, 22, 24) is determined and deviations between the current location and/or shape and a reference location and/or shape are determined. Based on the dosimetric data, a delivered dose distribution is compared with a planned dose distribution and deviations therebetween are determined. The deviations determined from the motion data and/or the dosimetric data are employed for adaptive planning, alignment, post treatment analysis, and safety.

摘要翻译： 治疗系统（10）包括一个或多个处理器（98,100）。 处理器（98,100）被编程为接收以下中的一个或多个：（1）植入患者体内和/或定位在患者体内的剂量计（26,28,202,204,206,208,210,212）的剂量测量数据 背心（200）; 和（2）植入患者体内的替代物（18,20,22,24）的运动数据。 基于运动数据，确定代理（18,20,22,24）的当前位置和/或形状，并且确定当前位置和/或形状与参考位置和/或形状之间的偏差。 基于剂量学数据，将递送的剂量分布与计划的剂量分布进行比较，并确定它们之间的偏差。 采用运动数据和/或剂量测量数据确定的偏差用于自适应规划，对准，后处理分析和安全性。

公开(公告)号：US20140193058A1

公开(公告)日：2014-07-10

申请号：US14237227

申请日：2012-07-24

申请人： Shyam Bharat ,  Vijay Parthasarathy

发明人： Shyam Bharat ,  Vijay Parthasarathy

IPC分类号： A61B5/00

CPC分类号： A61B5/0033 ,  A61B5/1126 ,  A61B5/721 ,  A61B2562/0233 ,  A61N5/103 ,  A61N5/1037 ,  A61N5/1038 ,  A61N5/1039 ,  A61N5/1049 ,  A61N5/1071 ,  A61N2005/1051 ,  A61N2005/1072 ,  G01T1/08 ,  G06T2207/30004

摘要： A therapy system (10) includes one or more processors (98, 100). The processors (98, 100) are programmed to receive one or more of: (1) dosimetric data from dosimeters (26, 28, 202, 204, 206, 208, 210, 212) implanted within a patient and/or positioned on a vest (200); and (2) motion data from surrogates (18, 20, 22, 24) implanted within the patient. Based on the motion data, a current location and/or shape of a surrogate (18, 20, 22, 24) is determined and deviations between the current location and/or shape and a reference location and/or shape are determined. Based on the dosimetric data, a delivered dose distribution is compared with a planned dose distribution and deviations therebetween are determined. The deviations determined from the motion data and/or the dosimetric data are employed for adaptive planning, alignment, post treatment analysis, and safety.

摘要翻译： 治疗系统（10）包括一个或多个处理器（98,100）。 处理器（98,100）被编程为接收以下中的一个或多个：（1）植入患者体内和/或定位在患者体内的剂量计（26,28,202,204,206,208,210,212）的剂量测量数据 背心（200）; 和（2）植入患者体内的替代物（18,20,22,24）的运动数据。 基于运动数据，确定代理（18,20,22,24）的当前位置和/或形状，并且确定当前位置和/或形状与参考位置和/或形状之间的偏差。 基于剂量学数据，将递送的剂量分布与计划的剂量分布进行比较，并确定它们之间的偏差。 采用运动数据和/或剂量测量数据确定的偏差用于自适应规划，对准，后处理分析和安全性。

公开(公告)号：US08328726B2

公开(公告)日：2012-12-11

申请号：US12416485

申请日：2009-04-01

申请人： Tomy Varghese ,  Shyam Bharat

发明人： Tomy Varghese ,  Shyam Bharat

IPC分类号： A61B8/14 ,  A61B8/00 ,  A61B5/103 ,  A61B5/117 ,  A61B18/04

CPC分类号： A61B18/18 ,  A61B5/0051 ,  A61B5/015 ,  A61B5/441 ,  A61B8/485 ,  A61B18/1815

摘要： Real-time monitoring of tissue ablation is possible by using a vibrating ablation needle coupling lateral shear waves to the tissue. Ultrasonic imaging may characterize the velocity of these shear waves to reveal Young's modulus of the tissue and, at a discontinuity in Young's modulus, a boundary of the ablated lesion reflecting an underlying increase in stiffness of ablated tissue. This technique may be coupled with quasi-static elastography-based ablation monitoring techniques for improved measurement.

摘要翻译： 通过使用振动消融针将横向剪切波耦合到组织，实现对组织消融的实时监测。 超声成像可以表征这些剪切波的速度，以显示组织的杨氏模量，并且在杨氏模量的不连续性处，消融的病变的边界反映消融组织的刚度的潜在增加。 该技术可以与基于准静态弹性成像的消融监测技术相结合，以改进测量。