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42 条记录 (耗时 0.048 秒)

    Bicyclic triazole α4 integrin inhibitors
    6.
    发明授权
    Bicyclic triazole α4 integrin inhibitors 失效
    双环三唑α4整联蛋白抑制剂

    公开(公告)号：US07618983B2

    公开(公告)日：2009-11-17

    申请号：US11269369

    申请日：2005-11-08

    申请人： Edward Lawson ,  Bruce Maryanoff

    发明人： Edward Lawson ,  Bruce Maryanoff

    IPC分类号： A61K31/4745 ,  A61K31/4196 ,  C07D487/02

    CPC分类号： C07D471/04 ,  C07D487/04

    摘要： The compounds of the present invention are novel bicyclic triazole amino acid-derivatives useful as α4 integrin receptor antagonists. The invention is further directed to methods for treating integrin mediated disorders including, but not limited to, inflammatory, autoimmune and cell-proliferative disorders, methods for preparing the compounds and methods for preparing the intermediates, derivatives and pharmaceutical compositions thereof.

    摘要翻译： 本发明的化合物是用作α4整联蛋白受体拮抗剂的新型双环三唑氨基酸衍生物。 本发明进一步涉及用于治疗整联蛋白介导的病症的方法，包括但不限于炎症，自身免疫和细胞增殖性疾病，制备化合物的方法及其制备方法，其衍生物和药物组合物。

    Substituted sulfamate anticonvulsant derivatives
    8.
    发明授权
    Substituted sulfamate anticonvulsant derivatives 有权
    取代氨基磺酸酯抗惊厥药衍生物

    公开(公告)号：US07560459B2

    公开(公告)日：2009-07-14

    申请号：US11265670

    申请日：2005-11-02

    申请人： Ahmed Abdel-Magid ,  Cynthia Maryanoff ,  Steven Mehrman ,  Allen B. Reitz ,  Bruce Maryanoff

    发明人： Ahmed Abdel-Magid ,  Cynthia Maryanoff ,  Steven Mehrman ,  Allen B. Reitz ,  Bruce Maryanoff

    IPC分类号： A61K31/255 ,  C07C311/01

    CPC分类号： C07H5/06 ,  C07H9/04

    摘要： The present invention is directed to novel compounds of the formula (I) wherein X, R1, R2, R3, R4, R5 and R6 are as described in the specification, processes for the preparation of and pharmaceutical compositions comprising said derivatives. The compounds of the present invention are useful for the treatment of epilepsy.The invention is further directed to a process for the preparation of compounds of formula (XX), wherein X, R3, R4, R5 and R6 are as described in the specification.

    摘要翻译： 本发明涉及式（I）的新化合物，其中X，R 1，R 2，R 3，R 4，R 5和R 6如说明书中所述，制备方法和包含所述衍生物的药物组合物。 本发明的化合物可用于治疗癫痫。 本发明还涉及制备式（XX）化合物的方法，其中X，R 3，R 4，R 5和R 6如说明书中所述。