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公开(公告)号：US20110105562A1
公开(公告)日：2011-05-05
申请号：US12914244
申请日：2010-10-28
申请人： Michael H. Parker , Dennis J. Hlasta , Yifang Huang , Allen B. Reitz , Edward C. Lawson , Carsten Schubert , Eric Strobel , Brett A. Tounge , Kimberly White , Michael P. Winters , Shyamali Ghosh
发明人： Michael H. Parker , Dennis J. Hlasta , Yifang Huang , Allen B. Reitz , Edward C. Lawson , Carsten Schubert , Eric Strobel , Brett A. Tounge , Kimberly White , Michael P. Winters , Shyamali Ghosh
IPC分类号： A61K31/454 , C07C237/20 , C07D211/46 , C07D401/12 , C07D409/12 , A61K31/165 , A61K31/45 , A61K31/4535 , A61P19/02 , A61P11/06 , A61P11/00 , A61P31/00 , A61P1/00 , A61P9/00
CPC分类号： C07C237/16 , C07C317/32 , C07D211/42 , C07D211/46 , C07D217/02 , C07D307/79 , C07D317/28 , C07D401/12 , C07D409/12
摘要： The present invention is directed to novel alkynyl derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by DPP-1.
摘要翻译： 本发明涉及新型炔基衍生物，含有它们的药物组合物及其用于治疗由DPP-1调节的病症和状况的用途。
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公开(公告)号：US20080039454A1
公开(公告)日：2008-02-14
申请号：US11881268
申请日：2007-07-26
申请人： Shyamali Ghosh , William Kinney , Edward Lawson , Diane Luci , Bruce Maryanoff , Francois Sommen , Yongchun Pan
发明人： Shyamali Ghosh , William Kinney , Edward Lawson , Diane Luci , Bruce Maryanoff , Francois Sommen , Yongchun Pan
IPC分类号： A61K31/538 , A61K31/4709 , A61P13/00 , A61P25/00 , A61P9/00 , C07D401/06 , C07D413/06
CPC分类号： C07D413/06 , C07D401/06 , C07D413/14 , C07D451/02
摘要： The invention is directed to Urotensin II receptor antagonists. More specifically, the present invention relates to certain novel compounds and methods for preparing compounds, compositions, intermediates and derivatives thereof. Pharmaceutical compositions and methods for treating or ameliorating a Urotensin-II mediated disorder using compounds of the invention are also described.
摘要翻译： 本发明涉及尿激素II受体拮抗剂。 更具体地，本发明涉及某些新化合物及其制备方法，其组合物，中间体及其衍生物。 还描述了使用本发明的化合物治疗或改善促rotensin-II介导的病症的药物组合物和方法。
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公开(公告)号：US09079896B2
公开(公告)日：2015-07-14
申请号：US12533257
申请日：2009-07-31
IPC分类号： C07D487/12 , C07D471/04 , C07D487/04
CPC分类号： C07D471/04 , C07D487/04
摘要： The present invention is directed to compounds of formula (I) and pharmaceutically acceptable salts, esters and prodrugs thereof, pharmaceutical compositions containing compounds of formula (I) and the use of said compounds and compositions as urotensin II receptor antagonists.
摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐，酯和前药，含有式（I）化合物的药物组合物以及所述化合物和组合物作为尿素转运蛋白II受体拮抗剂的用途。
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公开(公告)号：US08680278B2
公开(公告)日：2014-03-25
申请号：US12290438
申请日：2008-10-30
申请人： William A. Kinney , Christopher A. Teleha , Shyamali Ghosh , Bruce E. Maryanoff , Gabriela Grasa , Antonio Zanotti-Gerosa , Jonathan Alan Medlock
发明人： William A. Kinney , Christopher A. Teleha , Shyamali Ghosh , Bruce E. Maryanoff , Gabriela Grasa , Antonio Zanotti-Gerosa , Jonathan Alan Medlock
IPC分类号： C07D215/00 , C07D417/02 , C07D401/00
CPC分类号： C07D401/06 , B01J31/2213 , B01J31/2409 , B01J31/2495 , B01J2231/645 , B01J2531/0263 , B01J2531/0266 , B01J2531/821 , B01J2531/822 , B01J2531/827 , C07D405/14 , C07D471/04
摘要： The present invention is directed to a process for enantioselectively preparing substituted piperidine alkanoic acid integrin antagonist compounds.
摘要翻译： 本发明涉及对映选择性制备取代的哌啶链烷酸整联蛋白拮抗剂化合物的方法。
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公开(公告)号：US20110152321A1
公开(公告)日：2011-06-23
申请号：US12970247
申请日：2010-12-16
IPC分类号： A61K31/454 , C07D209/18 , A61K31/4045 , C07D401/14 , C07D417/12 , A61K31/427 , C07D403/12 , A61K31/4184 , A61P19/02 , A61P11/06 , A61P11/00 , A61P1/00
CPC分类号： C07D209/14 , C07D209/32 , C07D209/42 , C07D409/12 , C07D409/14 , C07D417/12
摘要： The present invention is directed to novel bicyclic derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by DPP-1.
摘要翻译： 本发明涉及新颖的双环衍生物，含有它们的药物组合物及其用于治疗由DPP-1调节的病症和状况的用途。
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公开(公告)号：US20110136824A1
公开(公告)日：2011-06-09
申请号：US13026549
申请日：2011-02-14
申请人： Bruce E. Maryanoff , William A. Kinney , Edward C. Lawson , Diane K. Luci , Nikolay Marchenko , Sergey Sviridov , Shyamali Ghosh
发明人： Bruce E. Maryanoff , William A. Kinney , Edward C. Lawson , Diane K. Luci , Nikolay Marchenko , Sergey Sviridov , Shyamali Ghosh
IPC分类号： A61K31/496 , C07D403/10 , C07D209/48 , A61K31/4035 , C07D403/14 , A61P9/00 , A61P13/12 , A61P1/18 , A61P25/28
CPC分类号： C07D209/48 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D451/14 , C07D487/08 , C07D513/04
摘要： The invention is directed to Urotensin II antagonists. More specifically, the present invention relates to certain novel compounds, methods for preparing compounds, compositions, intermediates and derivatives thereof and methods for treating Urotensin-II mediated disorders. Pharmaceutical and veterinary compositions and methods of treating cardiovascular disorders and various other disease states or conditions using compounds of the invention are also described.
摘要翻译： 本发明涉及尿激素II拮抗剂。 更具体地，本发明涉及某些新化合物，其制备方法，组合物，中间体及其衍生物以及用于治疗促肾上腺素II介导的病症的方法。 还描述了使用本发明化合物治疗心血管疾病和各种其它疾病状态或病症的药物和兽医组合物和方法。
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公开(公告)号：US08633322B2
公开(公告)日：2014-01-21
申请号：US12914244
申请日：2010-10-28
申请人： Michael H. Parker , Dennis J. Hlasta , Yifang Huang , Allen B. Reitz , Edward C. Lawson , Carsten Schubert , Eric Strobel , Brett A. Tounge , Kimberly White , Michael P. Winters , Shyamali Ghosh
发明人： Michael H. Parker , Dennis J. Hlasta , Yifang Huang , Allen B. Reitz , Edward C. Lawson , Carsten Schubert , Eric Strobel , Brett A. Tounge , Kimberly White , Michael P. Winters , Shyamali Ghosh
IPC分类号： A61K31/445 , C07D211/40
CPC分类号： C07C237/16 , C07C317/32 , C07D211/42 , C07D211/46 , C07D217/02 , C07D307/79 , C07D317/28 , C07D401/12 , C07D409/12
摘要： The present invention is directed to novel alkynyl derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by DPP-1.
摘要翻译： 本发明涉及新型炔基衍生物，含有它们的药物组合物及其用于治疗由DPP-1调节的病症和状况的用途。
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公开(公告)号：US08536174B2
公开(公告)日：2013-09-17
申请号：US13459708
申请日：2012-04-30
IPC分类号： A61K31/4995 , C07D487/08
CPC分类号： C07D209/48 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D451/14 , C07D487/08 , C07D513/04
摘要： The invention is directed to Urotensin II antagonists. More specifically, the present invention relates to certain novel compounds, methods for preparing compounds, compositions, intermediates and derivatives thereof and methods for treating Urotensin-II mediated disorders. Pharmaceutical and veterinary compositions and methods of treating cardiovascular disorders and various other disease states or conditions using compounds of the invention are also described.
摘要翻译： 本发明涉及尿激素II拮抗剂。 更具体地，本发明涉及某些新化合物，其制备方法，组合物，中间体及其衍生物以及用于治疗促肾上腺素II介导的病症的方法。 还描述了使用本发明化合物治疗心血管疾病和各种其它疾病状态或病症的药物和兽医组合物和方法。
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公开(公告)号：US08476302B2
公开(公告)日：2013-07-02
申请号：US13245137
申请日：2011-09-26
申请人： Michael N. Greco , Margery A. Connelly , Shyamali Ghosh , Dennis J. Hlasta , Edward C. Lawson , Eric Strobel , Michele A. Weidner-Wells , Hong Ye
发明人： Michael N. Greco , Margery A. Connelly , Shyamali Ghosh , Dennis J. Hlasta , Edward C. Lawson , Eric Strobel , Michele A. Weidner-Wells , Hong Ye
IPC分类号： A61K31/4245 , A61K31/4439 , A61K31/433 , C07D285/12 , C07D417/12 , C07D271/107
CPC分类号： C07D271/10 , C07D249/08 , C07D285/12 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention is directed to α-ketoamide derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by endothelial lipase, for example, cardiovascular disorders.
摘要翻译： 本发明涉及α-酮酰胺衍生物，含有它们的药物组合物及其用于治疗由内皮脂肪酶调节的病症和状况的用途，例如心血管疾病。
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公开(公告)号：US20110269768A1
公开(公告)日：2011-11-03
申请号：US13183121
申请日：2011-07-14
IPC分类号： A61K31/496 , C07D403/14 , C07D403/10 , C07D401/14 , C07D413/14 , A61K31/454 , A61P9/12 , A61P9/04 , A61P9/10 , A61P13/12 , A61P1/12 , A61P9/00 , A61P3/10 , A61P25/00 , A61P25/28 , A61P25/08 , A61P25/24 , A61P25/06 , A61P25/18 , A61P25/22 , A61P21/00 , C07D409/14
CPC分类号： C07D401/12 , C07D209/46 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12
摘要： This invention is directed to a compound of Formula (I): and forms thereof, wherein A, B, E, G, X and L2 are as defined herein and their use as urotensin II receptor antagonists.
摘要翻译： 本发明涉及式（I）的化合物及其形式，其中A，B，E，G，X和L2如本文所定义，以及它们作为尿素转运蛋白II受体拮抗剂的用途。
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