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    Substituted (quinolin-2-yl-methoxy)phenylthioureas
    1.
    发明授权
    Substituted (quinolin-2-yl-methoxy)phenylthioureas 失效
    取代（喹啉-2-基甲氧基）苯基

    公开(公告)号：US5120744A

    公开(公告)日：1992-06-09

    申请号：US593180

    申请日：1990-10-05

    申请人： Siegfried Raddatz ,  Klaus Mohrs ,  Burkhard Fugmann ,  Romanis Fruchtmann ,  Christian Kohlsdorfer ,  Reiner Muller-Peddinghaus ,  Pia Theisen-Popp

    发明人： Siegfried Raddatz ,  Klaus Mohrs ,  Burkhard Fugmann ,  Romanis Fruchtmann ,  Christian Kohlsdorfer ,  Reiner Muller-Peddinghaus ,  Pia Theisen-Popp

    IPC分类号： A61K31/47 ,  A61P7/02 ,  A61P9/06 ,  A61P9/08 ,  A61P9/10 ,  A61P11/00 ,  A61P29/00 ,  A61P37/08 ,  A61P43/00 ,  C07D215/14

    CPC分类号： C07D215/14

    摘要： Substituted (quinolin-2-ylmethoxy)phenyl-thio-ureas of the formula ##STR1## in which A, B, D, E, G, K and Mrepresent hydrogen, hydroxyl, halogen, carboxyl, nitro, trifluoromethyl or trifluoromethoxy, orrepresent alkyl, alkoxy or alkoxycarbonyl, orrepresent aryl, which is optionally substituted by halogen, hydroxyl, nitro or cyano,R.sup.1represents hydrogen or alkyl, which is optionally substituted by aryl or cycloalkyl, orrepresents cycloalkyl,R.sup.2represents alkyl, which is optionally substituted by halogen or hydroxy, orrepresents cycloalkyl, which is optionally substituted by halogen or cyano, orrepresents aryl which is optionally substituted by halogen, nitro, cyano, alkyl, or by --SO.sub.2 --R.sup.3, in whichR.sup.3 denotes alkyl or --NR.sup.4 R.sup.5, in whichR.sup.4 and R.sup.5 denote hydrogen, alkyl or phenyl, orR.sup.2 represents --CO--R.sup.6, in whichR.sup.6 denotes alkyl or aryl which is optionally substituted by halogen, nitro or cyano,and their salts, are useful for the inhibition of enzymatic reactions in the context of arachidonic acid metabolism.

    摘要翻译： 其中A，B，D，E，G，K和M代表氢，羟基，卤素，羧基，硝基，三氟甲基或（C 1 -C 6）烷基的取代的（喹啉-2-基甲氧基）苯基硫代脲 或代表烷基，烷氧基或烷氧基羰基，或表示任选被卤素，羟基，硝基或氰基取代的芳基，R 1表示氢或烷基，其任选被芳基或环烷基取代，或表示环烷基，R 2表示烷基， 其任选被卤素或羟基取代，或表示任选被卤素或氰基取代的环烷基，或表示任选被卤素，硝基，氰基，烷基或-SO 2 -R 3取代的芳基，其中R 3表示烷基 或-NR4R5，其中R4和R5表示氢，烷基或苯基，或R2表示-CO-R6，其中R6表示任选被卤素，硝基或氰基取代的烷基或芳基，及其盐可用于 在上下文中抑制酶反应 花生四烯酸代谢。

    Substituted (quinolin-2-yl-methoxy)phenyl-acyl-sulphon-amides and -cyanamides, processes for their preparation and their use in medicaments
    6.
    发明授权
    Substituted (quinolin-2-yl-methoxy)phenyl-acyl-sulphon-amides and -cyanamides, processes for their preparation and their use in medicaments 失效
    取代的（喹啉-2-基 - 甲氧基）苯基 - 亚氨基 - 磺酰胺和 - 亚胺，其制备方法及其在药物中的用途

    公开(公告)号：US5091392A

    公开(公告)日：1992-02-25

    申请号：US517108

    申请日：1990-05-01

    申请人： Siegfried Raddatz ,  Klaus-Helmut Mohrs ,  Romanis Fruchtmann ,  Christian Kohlsdorfer ,  Pia Theisen-Popp ,  Reiner Muller-Peddinghaus

    发明人： Siegfried Raddatz ,  Klaus-Helmut Mohrs ,  Romanis Fruchtmann ,  Christian Kohlsdorfer ,  Pia Theisen-Popp ,  Reiner Muller-Peddinghaus

    IPC分类号： A61K31/47 ,  A61P1/00 ,  A61P9/00 ,  A61P9/06 ,  A61P9/08 ,  A61P9/10 ,  A61P11/00 ,  A61P17/00 ,  A61P29/00 ,  A61P31/04 ,  A61P37/08 ,  A61P43/00 ,  C07D215/14 ,  C07D215/18 ,  C07D215/20 ,  C07D215/38

    CPC分类号： C07D215/14

    摘要： A quinolin-2-yl-methoxy)phenylacyl-sulphonamide or -cyanamide of the formula ##STR1## in which A, B, D, E, F and G are identical or different andrepresent hydrogen, hydroxyl, halogen, carboxyl, nitro, trifluoromethyl, trifluoromethoxy or a group of the formula --NH.sup.3 R.sup.4, in whichR.sup.3 and R.sup.4 are identical or different and denote hydrogen, straight-chain or branched alkyl having up to 8 carbon atoms or aryl having 6 to 10 carbon atoms,represent straight-chain or branched alkyl, alkoxy or alkoxycarbonyl in each case having up to 12 carbon atoms,represent aryl having 6 to 10 carbon atoms,R.sup.1 represents cycloalkyl having 3 to 8 carbon atoms,R.sup.2 represents hydrogen orstraight-chain or branched alkyl having up to 10 carbon atoms,represents an alkali metal,represents cycloalkyl having 3 to 8 carbon atoms,X represents a group of the formula --SO.sub.2 --R.sup.5, in whichR.sup.5 denotes trifluoromethyl or straight-chain or branches alkyl having up to 10 carbon atoms, ordenotes aryl having 6 to 10 carbon atoms, orX represents cyanoand physiologically acceptable salts thereof.The (quinolin-2-yl-methoxy)phenylacylsulphonamide or -cyanamide is useful as an active compound in medicaments, particularly as a lipoxygenase inhibitor.

    摘要翻译： 其中A，B，D，E，F和G相同或不同并且表示氢，羟基，卤素，羧基的式（I）的喹啉-2-基 - 甲氧基）苯甲酰基 - 磺酰胺或氰基酰胺 硝基，三氟甲基，三氟甲氧基或式-NH 3 R 4基团，其中R 3和R 4相同或不同并且表示氢，具有至多8个碳原子的直链或支链烷基或具有6至10个碳原子的芳基表示 在每种情况下具有至多12个碳原子的直链或支链烷基，烷氧基或烷氧基羰基表示具有6至10个碳原子的芳基，R 1表示具有3至8个碳原子的环烷基，R 2表示氢或具有直链或支链烷基的直链或支链烷基， 至多10个碳原子，代表碱金属，代表具有3-8个碳原子的环烷基，X代表式-SO2-R5的基团，其中R5代表三氟甲基或直链或支链烷基，最多具有10个碳原子 ，或表示具有6〜10个碳的芳基 或X表示氰基及其生理上可接受的盐。 （喹啉-2-基 - 甲氧基）苯基酰基磺酰胺或氰基酰胺可用作药物中的活性化合物，特别是脂氧合酶抑制剂。