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公开(公告)号：US20050239855A1
公开(公告)日：2005-10-27
申请号：US11112423
申请日：2005-04-22
IPC分类号： B22D11/10 , A61K31/416 , A61K31/4184 , A61K31/4375 , A61K31/443 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/4725 , A61K31/5377 , A61P9/00 , A61P35/00 , A61P43/00 , B22D41/50 , B22D41/56 , C07D231/56 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D471/04 , C07D521/00 , C07D43/02
CPC分类号： C07D249/08 , B22D41/56 , C07D231/12 , C07D231/56 , C07D233/56 , C07D401/04 , C07D401/14 , C07D403/04 , C07D471/04 , C07F7/1804
摘要： Indazole compounds that modulate and/or inhibit cell proliferation, such as the activity of protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating, e.g., kinases-dependent diseases to modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.
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2.发明申请Indazole compounds, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation 审中-公开吲唑化合物，药物组合物和介导或抑制细胞增殖的方法公开(公告)号：US20060111322A1
公开(公告)日：2006-05-25
申请号：US11329303
申请日：2006-01-10
IPC分类号： A61K31/695 , A61K31/69 , C07F5/02
CPC分类号： C07D249/08 , B22D41/56 , C07D231/12 , C07D231/56 , C07D233/56 , C07D401/04 , C07D401/14 , C07D403/04 , C07D471/04 , C07F7/1804
摘要： The invention is directed to intermediates useful for making indazole compounds that modulate and/or inhibit cell proliferation.
摘要翻译： 本发明涉及可用于制备调节和/或抑制细胞增殖的吲唑化合物的中间体。
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3.发明申请3, 5 disubstituted indazole compounds, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation 失效3,5-二取代吲唑化合物，药物组合物和介导或抑制细胞增殖的方法公开(公告)号：US20050026960A1
公开(公告)日：2005-02-03
申请号：US10866059
申请日：2004-06-10
IPC分类号： A61K31/416 , A61P35/00 , C07D401/14 , C07D413/04 , A61K31/4439 , C07
CPC分类号： C07D401/14
摘要： 3,5 disubstituted indazole compounds that modulate and/or inhibit cell proliferation, such as the activity of protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating CDK dependent diseases to modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.
摘要翻译： 描述了调节和/或抑制细胞增殖的3,5二取代吲唑化合物，例如蛋白激酶的活性。 这些化合物和含有它们的药物组合物能够介导CDK依赖性疾病调节和/或抑制不期望的细胞增殖。 本发明还涉及含有这些化合物的药物组合物的治疗或预防用途，以及治疗癌症以及与不想要的血管发生和/或细胞增殖相关的其它疾病状态的方法，例如糖尿病性视网膜病变，新生血管性青光眼，类风湿性关节炎 和牛皮癣，通过施用有效量的这种化合物。
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4.发明申请3,5 Disubstituted indazole compounds, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation 审中-公开3,5-二取代的吲唑化合物，药物组合物和介导或抑制细胞增殖的方法公开(公告)号：US20060142345A1
公开(公告)日：2006-06-29
申请号：US11237446
申请日：2005-09-26
IPC分类号： A61K31/4439
CPC分类号： C07D401/14
摘要： 3,5 disubstituted indazole compounds that modulate and/or inhibit cell proliferation, such as the activity of protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating CDK dependent diseases to modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.
摘要翻译： 描述了调节和/或抑制细胞增殖的3,5二取代吲唑化合物，例如蛋白激酶的活性。 这些化合物和含有它们的药物组合物能够介导CDK依赖性疾病调节和/或抑制不期望的细胞增殖。 本发明还涉及含有这些化合物的药物组合物的治疗或预防用途，以及治疗癌症以及与不想要的血管发生和/或细胞增殖相关的其它疾病状态的方法，例如糖尿病性视网膜病变，新生血管性青光眼，类风湿性关节炎 和牛皮癣，通过施用有效量的这种化合物。
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5.发明申请3,5 Disubstituted indazole compounds with nitrogen-bearing 5-membered heterocycles, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation 审中-公开3,5具有含氮5元杂环的二取代吲唑化合物，药物组合物和介导或抑制细胞增殖的方法公开(公告)号：US20050090529A1
公开(公告)日：2005-04-28
申请号：US10910217
申请日：2004-08-02
申请人： Indrawan McAlpine , Judith Deal , Mary Johnson , Susan Kephart , Julie Park , William Romines , Jayashree Tikhe
发明人： Indrawan McAlpine , Judith Deal , Mary Johnson , Susan Kephart , Julie Park , William Romines , Jayashree Tikhe
IPC分类号： A61K31/4439 , C07D401/14 , C07D453/02 , C07D471/04 , C07D43/14
CPC分类号： C07D401/14 , A61K31/4439 , C07D453/02 , C07D471/04
摘要： 3,5 disubstituted indazole compounds with substituted nitrogen bearing 5-membered heterocycles in the 3-position that modulate and/or inhibit cell proliferation, such as the activity of protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating CDK dependent diseases to modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.
摘要翻译： 描述了调节和/或抑制细胞增殖的3位中具有取代的含氮5位杂环的3,5-二取代吲唑化合物，例如蛋白激酶的活性。 这些化合物和含有它们的药物组合物能够介导CDK依赖性疾病调节和/或抑制不期望的细胞增殖。 本发明还涉及含有这些化合物的药物组合物的治疗或预防用途，以及治疗癌症以及与不想要的血管发生和/或细胞增殖相关的其它疾病状态的方法，例如糖尿病性视网膜病变，新生血管性青光眼，类风湿性关节炎 和牛皮癣，通过施用有效量的这种化合物。
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