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公开(公告)号：US11096648B2
公开(公告)日：2021-08-24
申请号：US15733431
申请日：2019-01-22
摘要： For dose calibration (39) in functional imaging, different precision sources (22, 25) for a same long-lived isotope are used to calibrate, avoiding having to ship one source from one location to another location. A ratio of sensitivities of a gas ion chamber-based dose calibrator (20) at a reference laboratory to the precision source (22) of the long-lived isotope to a source (23) with an isotope to be used for imaging is found. At the clinical site (e.g., radio-pharmacy or functional imaging facility), a measure (34) of the sensitivity of a local gas ion chamber-based dose calibrator (24) to the other source (25) with the long-lived isotope and the ratio from the remote gas ion chamber-based dose calibrator (20) are used to determine sensitivity of the local gas ion chamber-based dose calibrator (24) to the isotope of the radiopharmaceutical (26). The bias and corresponding dose for the radiopharmaceutical (26) to be used for imaging a patient are based on activity for the radiopharmaceutical (26) as calibrated to account for the sensitivity of the local gas ion chamber-based dose calibrator (24) to the isotope of the radiopharmaceutical (26).
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公开(公告)号：US09867581B2
公开(公告)日：2018-01-16
申请号：US14595254
申请日：2015-01-13
CPC分类号： A61B6/037 , A61B6/4258 , A61B6/461 , A61B6/52 , A61B6/582
摘要： Cross-calibration is provided for functional imaging. In PET or SPECT, the inaccuracies from the dose and detector sensitivity may be reduced or removed in both activity concentration and uptake. By using measures from both the radiotracer for the patient and factory calibrated sources, the variability due to dose may be removed. In SPECT, a measurement of system specific sensitivity to a factory calibrated point source is used to improve the accuracy of uptake values, not just activity concentration.
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公开(公告)号：US20170192104A1
公开(公告)日：2017-07-06
申请号：US15315151
申请日：2015-06-12
IPC分类号： G01T1/164 , G01T1/166 , G01T1/24 , A61B6/00 , G01T7/00 , G01T1/208 , G01T1/40 , G12B13/00 , G01T1/29
CPC分类号： G01T1/1647 , A61B6/582 , G01T1/1642 , G01T1/166 , G01T1/208 , G01T1/247 , G01T1/249 , G01T1/2964 , G01T1/40 , G01T7/005 , G12B13/00
摘要： For calibration (24) for quantitative SPECT, a multiple energy emission source (11) is used for calibration. The planar sensitivities and/or uniformities are determined at different emission energies based on detections from the multiple energy emission source. For estimating (32) the activity concentration, sensitivities and/or uniformities based on measures (26) at different emission energies increase accuracy. The multiple energy emission source (11) may alternatively or additionally be used to calibrate (40) a dose calibrator (15).
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公开(公告)号：US20170188982A1
公开(公告)日：2017-07-06
申请号：US15315107
申请日：2015-06-08
摘要： For dead time determination for a gamma camera (18) or other detector, a long-lived point source (26) of emissions is positioned so that the gamma camera (18) detects (34) the emissions from the source (26) while also being used to detect (36) emissions from the patient (22). The long-lived point source (26), in the scan time, acts as a fixed frequency source (26) of emissions, allowing for dead time correction measurements that include the crystal detector effects.
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公开(公告)号：US20160356894A1
公开(公告)日：2016-12-08
申请号：US14964710
申请日：2015-12-10
摘要： For dead time compensation, a point source with a same radioisotope as used for the radiopharmaceutical is positioned by the detector. Counts from the point source without the patient and with the patient are used to correct the system or detector sensitivity. Reconstruction is performed with the sensitivity normalized for count rate, compensating for the dead time and spectral broadening.
摘要翻译： 对于死区时间补偿，具有与用于放射性药物的相同放射性同位素的点源由检测器定位。 来自没有患者和患者的点源的计数用于校正系统或检测器灵敏度。 以计数率标准化的灵敏度进行重建，补偿死区时间和频谱展宽。
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公开(公告)号：US20220099845A1
公开(公告)日：2022-03-31
申请号：US17643460
申请日：2021-12-09
摘要： For dead time determination for a gamma camera or other detector, a long-lived point source of emissions is positioned so that the gamma camera detects the emissions from the source while also being used to detect emissions from the patient. The long-lived point source, in the scan time, acts as a fixed frequency source of emissions, allowing for dead time correction measurements that include the crystal detector effects.
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公开(公告)号：US20210093283A1
公开(公告)日：2021-04-01
申请号：US15733431
申请日：2019-01-22
摘要： For dose calibration (39) in functional imaging, different precision sources (22, 25) for a same long-lived isotope are used to calibrate, avoiding having to ship one source from one location to another location. A ratio of sensitivities of a gas ion chamber-based dose calibrator (20) at a reference laboratory to the precision source (22) of the long-lived isotope to a source (23) with an isotope to be used for imaging is found. At the clinical site (e.g., radio-pharmacy or functional imaging facility), a measure (34) of the sensitivity of a local gas ion chamber-based dose calibrator (24) to the other source (25) with the long-lived isotope and the ratio from the remote gas ion chamber-based dose calibrator (20) are used to determine sensitivity of the local gas ion chamber-based dose calibrator (24) to the isotope of the radiopharmaceutical (26). The bias and corresponding dose for the radiopharmaceutical (26) to be used for imaging a patient are based on activity for the radiopharmaceutical (26) as calibrated to account for the sensitivity of the local gas ion chamber-based dose calibrator (24) to the isotope of the radiopharmaceutical (26).
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公开(公告)号：US10820880B2
公开(公告)日：2020-11-03
申请号：US15337288
申请日：2016-10-28
摘要： A detector of a gamma camera is configured such that a radioactive point source is positioned within a field of view at a fixed distance from the detector. A predetermined number of gamma photons emitted by the point source and passed through a collimator are acquired. A system-specific planar sensitivity is computed for a combination of the collimator and detector using the number of gamma photons acquired, a time duration of the acquisition, and precalibrated radioactivity data of the point source corrected for decay that occurred after a precalibration time. A deviation of the computed system-specific planar sensitivity from a class standard sensitivity value for a combination of the radioactive point source, the collimator, and the detector is computed. A class standard sensitivity value for a combination of a radiopharmaceutical, the collimator, and the detector is scaled by the computed deviation, yielding a scaled system-specific sensitivity value for the radiopharmaceutical.
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公开(公告)号：US20170042500A1
公开(公告)日：2017-02-16
申请号：US15337288
申请日：2016-10-28
CPC分类号： A61B6/582 , A61B6/037 , A61B6/4258 , G01T1/1647 , G01T7/005
摘要： A detector of a gamma camera is configured such that a radioactive point source is positioned within a field of view at a fixed distance from the detector. A predetermined number of gamma photons emitted by the point source and passed through a collimator are acquired. A system-specific planar sensitivity is computed for a combination of the collimator and detector using the number of gamma photons acquired, a time duration of the acquisition, and precalibrated radioactivity data of the point source corrected for decay that occurred after a precalibration time. A deviation of the computed system-specific planar sensitivity from a class standard sensitivity value for a combination of the radioactive point source, the collimator, and the detector is computed. A class standard sensitivity value for a combination of a radiopharmaceutical, the collimator, and the detector is scaled by the computed deviation, yielding a scaled system-specific sensitivity value for the radiopharmaceutical.
摘要翻译： 伽马照相机的检测器被配置为使得放射性点源位于与检测器固定距离的视场内。 获取由点源发射并通过准直仪的预定数量的γ光子。 对于准直器和检测器的组合，使用所获取的伽马光子的数量，采集的持续时间以及在预校准时间之后发生的衰变校正的点源的预校准的放射性数据来计算系统特定的平面灵敏度。 计算出计算出的系统特定平面灵敏度与放射性点源，准直器和检测器的组合的类标准灵敏度值的偏差。 放射性药物，准直仪和检测器的组合的类标准灵敏度值通过计算的偏差进行缩放，产生用于放射性药物的缩放的系统特异性灵敏度值。
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公开(公告)号：US20150196268A1
公开(公告)日：2015-07-16
申请号：US14595254
申请日：2015-01-13
CPC分类号： A61B6/037 , A61B6/4258 , A61B6/461 , A61B6/52 , A61B6/582
摘要： Cross-calibration is provided for functional imaging. In PET or SPECT, the inaccuracies from the dose and detector sensitivity may be reduced or removed in both activity concentration and uptake. By using measures from both the radiotracer for the patient and factory calibrated sources, the variability due to dose may be removed. In SPECT, a measurement of system specific sensitivity to a factory calibrated point source is used to improve the accuracy of uptake values, not just activity concentration.
摘要翻译： 为功能成像提供交叉校准。 在PET或SPECT中，剂量和检测器灵敏度的不准确度可以在活性浓度和摄取两者中降低或去除。 通过使用放射性示踪剂对患者和工厂校准的来源进行测量，可能会消除由于剂量导致的变异性。 在SPECT中，使用对工厂校准点源的系统特异性灵敏度的测量来提高摄取值的准确性，而不仅仅是活动浓度。
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