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![PHARMACEUTICAL FORMULATIONS, PROCESSES, SOLID FORMS AND METHODS OF USE RELATING TO 1-ETHYL-7-(2-METHYL-6-(1H-1,2,4-TRIAZOL-3-YL)PYRIDIN-3-YL)-3,4-DIHYDROPYRAZINO[2,3-b]PYRAZIN-2(1H)-ONE](/abs-image/US/2018/02/15/US20180042924A1/abs.jpg.150x150.jpg)
公开(公告)号：US20180042924A1
公开(公告)日：2018-02-15
申请号：US15790177
申请日：2017-10-23
发明人： Anil Menon , Darshan K. Parikh , Dora Visky , Matthew Michael Kreilein , Nathan Boersen , Thomas Lee , Ying Li , Jean Xu , Xiaozhang Liang , William Wei-Hwa Leong , Benjamin Cohen
IPC分类号： A61K31/4985 , A61K9/48 , A61K9/20 , C07D487/04 , C07D471/04
CPC分类号： A61K31/4985 , A61K9/2018 , A61K9/2054 , A61K9/4858 , C07D471/04 , C07D487/04
摘要： Provided herein are formulations, processes, solid forms and methods of use relating to 1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2 (1H)-one.
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![Pharmaceutical compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino [2,3-B]pyrazin-2(1H)-one, a solid form thereof and methods of their use](/abs-image/US/2017/10/24/US09795603B2/abs.jpg.150x150.jpg)
公开(公告)号：US09795603B2
公开(公告)日：2017-10-24
申请号：US15427242
申请日：2017-02-08
发明人： Marie Georges Beauchamps , Antonio Christian Ferretti , Juan Antonio Gamboa , Kevin Klopfer , William Edward Konnecke , Matthew Michael Kreilein , Anil Menon , Amanda Nicole Miklos , John Fitzgerald Traverse
IPC分类号： A61K31/4985 , A61K9/28 , A61K9/20 , C07D487/04
CPC分类号： A61K31/4985 , A61K9/2013 , A61K9/2018 , A61K9/2054 , A61K9/28 , A61K9/2866 , C07B59/00 , C07B2200/13 , C07D241/20 , C07D487/04
摘要： Provided herein are compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one, solid forms, isotopologues and metabolites thereof, and methods of their use for the treatment of a disease, disorder, or condition.
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![Pharmaceutical formulations, processes, solid forms and methods of use relating to 1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b] pyrazin-2(1H)-one](/abs-image/US/2016/06/07/US09359364B2/abs.jpg.150x150.jpg)
3.发明授权Pharmaceutical formulations, processes, solid forms and methods of use relating to 1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b] pyrazin-2(1H)-one 有权涉及1-乙基-7-（2-甲基-6-（1H-1,2,4-三唑-3-基）吡啶-3-基）-3的药物制剂，方法，固体形式和使用方法， 2,3-二氢吡嗪并[2,3-b]吡嗪-2（1H） - 酮公开(公告)号：US09359364B2
公开(公告)日：2016-06-07
申请号：US14254023
申请日：2014-04-16
发明人： Anil Menon , Darshan K. Parikh , Dora Visky , Matthew Michael Kreilein , Nathan Boersen , Thomas Lee , Ying Li , Jean Xu , Xiaozhang Liang , William Wei-Hwa Leong , Benjamin Cohen
IPC分类号： C07D487/04 , A61K31/4985 , C07D471/04 , A61K9/20 , A61K9/48
CPC分类号： A61K31/4985 , A61K9/2018 , A61K9/2054 , A61K9/4858 , C07D471/04 , C07D487/04
摘要： Provided herein are formulations, processes, solid forms and methods of use relating to 1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one.
摘要翻译： 本文提供了涉及1-乙基-7-（2-甲基-6-（1H-1,2,4-三唑-3-基）吡啶-3-基） - 哌嗪的制剂，方法，固体形式和使用方法 3,4-二氢吡嗪并[2,3-b]吡嗪-2（1H） - 酮。
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![Pharmaceutical formulations, processes, solid forms and methods of use relating to 1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one](/abs-image/US/2018/08/21/US10052322B2/abs.jpg.150x150.jpg)
公开(公告)号：US10052322B2
公开(公告)日：2018-08-21
申请号：US15790177
申请日：2017-10-23
发明人： Anil Menon , Darshan K. Parikh , Dora Visky , Nathan Boersen , Thomas Lee , Xiaozhang Liang
IPC分类号： A61K31/4985 , A61K9/48 , A61K9/20 , C07D471/04 , C07D487/04
CPC分类号： A61K31/4985 , A61K9/2018 , A61K9/2054 , A61K9/4858 , A61P35/00 , C07D471/04 , C07D487/04
摘要： Provided herein are formulations, processes, solid forms and methods of use relating to 1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one.
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![Pharmaceutical compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino[2,3- B]pyrazin-2(1H)-one, a solid form there of and methods of their use](/abs-image/US/2018/05/22/US09974786B2/abs.jpg.150x150.jpg)
公开(公告)号：US09974786B2
公开(公告)日：2018-05-22
申请号：US15708222
申请日：2017-09-19
发明人： Marie Georges Beauchamps , Antonio Christian Ferretti , Juan Antonio Gamboa , Kevin Klopfer , William Edward Konnecke , Matthew Michael Kreilein , Anil Menon , Amanda Nicole Miklos , John Fitzgerald Traverse
IPC分类号： A61K31/4985 , C07D487/04 , A61K9/20 , A61K9/28
CPC分类号： A61K31/4985 , A61K9/2013 , A61K9/2018 , A61K9/2054 , A61K9/28 , A61K9/2866 , C07B59/00 , C07B2200/13 , C07D241/20 , C07D487/04
摘要： Provided herein are compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one, solid forms, isotopologs and metabolites thereof, and methods of their use for the treatment of a disease, disorder, or condition.
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![PHARMACEUTICAL FORMULATIONS, PROCESSES, SOLID FORMS AND METHODS OF USE RELATING TO 1-ETHYL-7-(2-METHYL-6-(1H-1,2,4-TRIAZOL-3-YL)PYRIDIN-3-YL)-3,4-DIHYDROPYRAZINO[2,3-b]PYRAZIN-2(1H)-ONE](/abs-image/US/2016/09/01/US20160250210A1/abs.jpg.150x150.jpg)
6.发明申请PHARMACEUTICAL FORMULATIONS, PROCESSES, SOLID FORMS AND METHODS OF USE RELATING TO 1-ETHYL-7-(2-METHYL-6-(1H-1,2,4-TRIAZOL-3-YL)PYRIDIN-3-YL)-3,4-DIHYDROPYRAZINO[2,3-b]PYRAZIN-2(1H)-ONE 审中-公开药用制剂，方法，固体形式和与1-乙基-7-（2-甲基-6-（1H-1,2,4-三唑-3-基）吡啶-3-基）-3， [2,3-b]吡嗪-2（1H） - 酮公开(公告)号：US20160250210A1
公开(公告)日：2016-09-01
申请号：US15150577
申请日：2016-05-10
发明人： Anil Menon , Darshan K. Parikh , Dora Visky , Matthew Michael Kreilein , Nathan Boersen , Thomas Lee , Ying Li , Jean Xu , Xiaozhang Liang , William Wei-Hwa Leong , Benjamin Cohen
IPC分类号： A61K31/4985
CPC分类号： A61K31/4985 , A61K9/2018 , A61K9/2054 , A61K9/4858 , C07D471/04 , C07D487/04
摘要： Provided herein are formulations, processes, solid forms and methods of use relating to 1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one.
摘要翻译： 本文提供了涉及1-乙基-7-（2-甲基-6-（1H-1,2,4-三唑-3-基）吡啶-3-基） - 哌嗪的制剂，方法，固体形式和使用方法 3,4-二氢吡嗪并[2,3-b]吡嗪-2（1H） - 酮。
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![Pharmaceutical compositions of 7-(6-(2-hydroxypropan-2-YL)pyridin-3-YL)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino [2,3-B]pyrazin-2(1H)-one, a solid form thereof and methods of their use](/abs-image/US/2017/03/28/US09604939B2/abs.jpg.150x150.jpg)
公开(公告)号：US09604939B2
公开(公告)日：2017-03-28
申请号：US14288521
申请日：2014-05-28
发明人： Marie Georges Beauchamps , Antonio Christian Ferretti , Juan Antonio Gamboa , Kevin Klopfer , William Edward Konnecke , Matthew Michael Kreilein , Anil Menon , Amanda Nicole Miklos , John Fitzgerald Traverse
IPC分类号： C07D241/20 , A61K9/28 , C07B59/00 , A61K9/20 , A61K31/4985 , C07D487/04
CPC分类号： A61K31/4985 , A61K9/2013 , A61K9/2018 , A61K9/2054 , A61K9/28 , A61K9/2866 , C07B59/00 , C07B2200/13 , C07D241/20 , C07D487/04
摘要： Provided herein are compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one, solid forms, isotopologs and metabolites thereof, and methods of their use for the treatment of a disease, disorder, or condition.
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![Pharmaceutical compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino [2,3-b]pyrazin-2(1H)-one, a solid form thereof and methods of their use](/abs-image/US/2016/08/02/US09403829B2/abs.jpg.150x150.jpg)
8.发明授权Pharmaceutical compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino [2,3-b]pyrazin-2(1H)-one, a solid form thereof and methods of their use 有权将（7-（6-羟基丙-2-基）吡啶-3-基）-1 - （（反式）-4-甲氧基环己基）-3,4-二氢吡嗪并[2,3-b] 2（1H） - 酮，其固体形式及其使用方法公开(公告)号：US09403829B2
公开(公告)日：2016-08-02
申请号：US13689972
申请日：2012-11-30
发明人： Terrence Joseph Connolly , Kevin Joseph Klopfer , William Wei-Hwa Leong , Anil Menon , Amanda Nicole Miklos , Nathan Boersen , Benjamin Cohen , Juan Antonio Gamboa , Ho-Wah Hui , Matthew Michael Kreilein , Thomas Lee , Ying Li , Jean Xu
IPC分类号： A61K9/20 , C07D487/04 , A61K31/4985
CPC分类号： C07D487/04 , A61K9/2013 , A61K9/2018 , A61K9/2054 , A61K9/2095 , A61K31/4985
摘要： Provided herein are compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one, solid forms, isotopologues and metabolites thereof, and methods of their use for the treatment of a disease, disorder, or condition.
摘要翻译： 本文提供的是7-（6-（2-羟基丙-2-基）吡啶-3-基）-1 - （（反式）-4-甲氧基环己基）-3,4-二氢吡嗪并[2,3-b] 吡嗪-2（1H） - 酮，其形式，同位素和代谢物及其用于治疗疾病，病症或病症的方法。
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![PHARMACEUTICAL FORMULATIONS, PROCESSES, SOLID FORMS AND METHODS OF USE RELATING TO 1-ETHYL-7-(2-METHYL-6-(1H-1,2,4-TRIAZOL-3-YL)PYRIDIN-3-YL)-3,4-DIHYDROPYRAZINO[2,3-b]PYRAZIN-2(1H)-ONE](/abs-image/US/2014/10/23/US20140315908A1/abs.jpg.150x150.jpg)
9.发明申请PHARMACEUTICAL FORMULATIONS, PROCESSES, SOLID FORMS AND METHODS OF USE RELATING TO 1-ETHYL-7-(2-METHYL-6-(1H-1,2,4-TRIAZOL-3-YL)PYRIDIN-3-YL)-3,4-DIHYDROPYRAZINO[2,3-b]PYRAZIN-2(1H)-ONE 有权药用制剂，方法，固体形式和与1-乙基-7-（2-甲基-6-（1H-1,2,4-三唑-3-基）吡啶-3-基）-3， [2,3-b]吡嗪-2（1H） - 酮公开(公告)号：US20140315908A1
公开(公告)日：2014-10-23
申请号：US14254023
申请日：2014-04-16
发明人： Anil Menon , Darshan K. Parikh , Dora Visky , Matthew Michael Kreilein , Nathan Boersen , Thomas Lee , Ying Li , Jean Xu , Xiaozhang Liang , William Wei-Hwa Leong , Benjamin Cohen
IPC分类号： C07D487/04
CPC分类号： A61K31/4985 , A61K9/2018 , A61K9/2054 , A61K9/4858 , C07D471/04 , C07D487/04
摘要： Provided herein are formulations, processes, solid forms and methods of use relating to 1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one.
摘要翻译： 本文提供了涉及1-乙基-7-（2-甲基-6-（1H-1,2,4-三唑-3-基）吡啶-3-基） - 哌嗪的制剂，方法，固体形式和使用方法 3,4-二氢吡嗪并[2,3-b]吡嗪-2（1H） - 酮。
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