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公开(公告)号：US10513519B2
公开(公告)日：2019-12-24
申请号：US16027503
申请日：2018-07-05
发明人： Zheng Chen , Paul F. Fernandez , Tracy L. Gaebele , Lianfeng Huang , Matthew J. Jackson , Matthew M. Kreilein , Xiaoling Lu , Wenju Wu , Jean Xu
IPC分类号： C07D473/32
摘要： Provided herein are formulations, solid forms and methods of use relating to (1s,4s)-4-(2-(((3S,4R)-3-fluorotetrahydro-2H-pyran-4-yl)amino)-8-((2,4,6-trichlorophenyl)amino)-9H-purin-9-yl)-1-methylcyclohexane-1-carboxamide.
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公开(公告)号：US10047090B2
公开(公告)日：2018-08-14
申请号：US15475836
申请日：2017-03-31
发明人： Zheng Chen , Paul F. Fernandez , Tracy L. Gaebele , Lianfeng Huang , Matthew J. Jackson , Matthew M. Kreilein , Xiaoling Lu , Wenju Wu , Jean Xu
IPC分类号： C07D473/32
摘要： Provided herein are formulations, solid forms and methods of use relating to (1s,4s)-4-(2-(((3S,4R)-3-fluorotetrahydro-2H-pyran-4-yl)amino)-8-((2,4,6-trichlorophenyl)amino)-9H-purin-9-yl)-1-methylcyclohexane-1-carboxamide.
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公开(公告)号：US20170283418A1
公开(公告)日：2017-10-05
申请号：US15475836
申请日：2017-03-31
发明人： Zheng Chen , Paul F. Fernandez , Tracy L. Gaebele , Lianfeng Huang , Matthew J. Jackson , Matthew M. Kreilein , Xiaoling Lu , Wenju Wu , Jean Xu
IPC分类号： C07D473/32
CPC分类号： C07D473/32 , C07B2200/13
摘要： Provided herein are formulations, solid forms and methods of use relating to (1s,4s)-4-(2-(((3S,4R)-3-fluorotetrahydro-2H-pyran-4-yl)amino)-8-((2,4, 6-trichlorophenyl)amino)-9H-purin-9-yl)-1-methylcyclohexane-1-carboxamide.
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4.发明授权Solid forms of 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide, compositions thereof and methods of their use 有权固体形式的2-（叔丁基氨基）-4 - （（1R，3R，4R）-3-羟基-4-甲基环己基氨基） - 嘧啶-5-甲酰胺及其使用方法公开(公告)号：US09365524B2
公开(公告)日：2016-06-14
申请号：US14608314
申请日：2015-01-29
发明人： Hon-Wah Man , Jean Xu , Marie Georges Beauchamps , Mohit Atul Kothare , Nanfei Zou , Ying Li , Lianfeng Huang , Daozhong Zou
IPC分类号： A61K31/505 , C07D239/48 , C07D239/42
CPC分类号： A61K31/505 , C07D239/42 , C07D239/48
摘要： Provided herein are formulations, processes, solid forms and methods of use relating to 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide.
摘要翻译： 本文提供了与2-（叔丁基氨基）-4 - （（1R，3R，4R）-3-羟基-4-甲基环己基氨基） - 嘧啶-5-甲酰胺相关的制剂，方法，固体形式和使用方法。
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公开(公告)号：US20180362529A1
公开(公告)日：2018-12-20
申请号：US16027503
申请日：2018-07-05
发明人： Zheng Chen , Paul F. Fernandez , Tracy L. Gaebele , Lianfeng Huang , Matthew J. Jackson , Matthew M. Kreilein , Xiaoling Lu , Wenju Wu , Jean Xu
IPC分类号： C07D473/32
摘要： Provided herein are formulations, solid forms and methods of use relating to (1s,4s)-4-(2-(((3S,4R)-3-fluorotetrahydro-2H-pyran-4-yl)amino)-8-((2,4,6-trichlorophenyl)amino)-9H-purin-9-yl)-1-methylcyclohexane-1-carboxamide.
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![PHARMACEUTICAL FORMULATIONS, PROCESSES, SOLID FORMS AND METHODS OF USE RELATING TO 1-ETHYL-7-(2-METHYL-6-(1H-1,2,4-TRIAZOL-3-YL)PYRIDIN-3-YL)-3,4-DIHYDROPYRAZINO[2,3-b]PYRAZIN-2(1H)-ONE](/abs-image/US/2016/09/01/US20160250210A1/abs.jpg.150x150.jpg)
6.发明申请PHARMACEUTICAL FORMULATIONS, PROCESSES, SOLID FORMS AND METHODS OF USE RELATING TO 1-ETHYL-7-(2-METHYL-6-(1H-1,2,4-TRIAZOL-3-YL)PYRIDIN-3-YL)-3,4-DIHYDROPYRAZINO[2,3-b]PYRAZIN-2(1H)-ONE 审中-公开药用制剂，方法，固体形式和与1-乙基-7-（2-甲基-6-（1H-1,2,4-三唑-3-基）吡啶-3-基）-3， [2,3-b]吡嗪-2（1H） - 酮公开(公告)号：US20160250210A1
公开(公告)日：2016-09-01
申请号：US15150577
申请日：2016-05-10
发明人： Anil Menon , Darshan K. Parikh , Dora Visky , Matthew Michael Kreilein , Nathan Boersen , Thomas Lee , Ying Li , Jean Xu , Xiaozhang Liang , William Wei-Hwa Leong , Benjamin Cohen
IPC分类号： A61K31/4985
CPC分类号： A61K31/4985 , A61K9/2018 , A61K9/2054 , A61K9/4858 , C07D471/04 , C07D487/04
摘要： Provided herein are formulations, processes, solid forms and methods of use relating to 1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one.
摘要翻译： 本文提供了涉及1-乙基-7-（2-甲基-6-（1H-1,2,4-三唑-3-基）吡啶-3-基） - 哌嗪的制剂，方法，固体形式和使用方法 3,4-二氢吡嗪并[2,3-b]吡嗪-2（1H） - 酮。
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7.发明申请SOLID FORMS OF 2-(TERT-BUTYLAMINO)-4-((1R,3R,4R)-3-HYDROXY-4-METHYLCYCLOHEXYLAMINO)-PYRIMIDINE-5-CARBOXAMIDE, COMPOSITIONS THEREOF AND METHODS OF THEIR USE 有权2-（叔丁基氨基）-4 - （（1R，3R，4R）-3-羟基-4-甲基环己基氨基） - 嘧啶-5-羧酰胺的固体形式及其组合物及其使用方法公开(公告)号：US20150210650A1
公开(公告)日：2015-07-30
申请号：US14608314
申请日：2015-01-29
发明人： Antonio Christian Ferretti , Hon-Wah Man , Jale Muslehiddinoglu , Jean Xu , Kelvin Hin-Yeong Yong , Marie Georges Beauchamps , Mohit Atul Kothare , Nanfei Zou , Nathan Andrew Boersen , Ying Li , Ying Ye
IPC分类号： C07D239/48 , C07D239/42
CPC分类号： A61K31/505 , C07D239/42 , C07D239/48
摘要： Provided herein are formulations, processes, solid forms and methods of use relating to 2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide.
摘要翻译： 本文提供了与2-（叔丁基氨基）-4 - （（1R，3R，4R）-3-羟基-4-甲基环己基氨基） - 嘧啶-5-甲酰胺相关的制剂，方法，固体形式和使用方法。
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![Pharmaceutical formulations, processes, solid forms and methods of use relating to 1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one](/abs-image/US/2017/11/28/US09827243B2/abs.jpg.150x150.jpg)
公开(公告)号：US09827243B2
公开(公告)日：2017-11-28
申请号：US15150577
申请日：2016-05-10
发明人： Matthew Michael Kreilein , Thomas Lee , Ying Li , Jean Xu , William Wei-Hwa Leong , Benjamin Cohen
IPC分类号： C07D487/04 , A61K31/4985 , C07D471/04 , A61K9/20 , A61K9/48
CPC分类号： A61K31/4985 , A61K9/2018 , A61K9/2054 , A61K9/4858 , C07D471/04 , C07D487/04
摘要： Provided herein are formulations, processes, solid forms and methods of use relating to 1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one.
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![Pharmaceutical formulations, processes, solid forms and methods of use relating to 1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b] pyrazin-2(1H)-one](/abs-image/US/2016/06/07/US09359364B2/abs.jpg.150x150.jpg)
9.发明授权Pharmaceutical formulations, processes, solid forms and methods of use relating to 1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b] pyrazin-2(1H)-one 有权涉及1-乙基-7-（2-甲基-6-（1H-1,2,4-三唑-3-基）吡啶-3-基）-3的药物制剂，方法，固体形式和使用方法， 2,3-二氢吡嗪并[2,3-b]吡嗪-2（1H） - 酮公开(公告)号：US09359364B2
公开(公告)日：2016-06-07
申请号：US14254023
申请日：2014-04-16
发明人： Anil Menon , Darshan K. Parikh , Dora Visky , Matthew Michael Kreilein , Nathan Boersen , Thomas Lee , Ying Li , Jean Xu , Xiaozhang Liang , William Wei-Hwa Leong , Benjamin Cohen
IPC分类号： C07D487/04 , A61K31/4985 , C07D471/04 , A61K9/20 , A61K9/48
CPC分类号： A61K31/4985 , A61K9/2018 , A61K9/2054 , A61K9/4858 , C07D471/04 , C07D487/04
摘要： Provided herein are formulations, processes, solid forms and methods of use relating to 1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one.
摘要翻译： 本文提供了涉及1-乙基-7-（2-甲基-6-（1H-1,2,4-三唑-3-基）吡啶-3-基） - 哌嗪的制剂，方法，固体形式和使用方法 3,4-二氢吡嗪并[2,3-b]吡嗪-2（1H） - 酮。
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![PHARMACEUTICAL FORMULATIONS, PROCESSES, SOLID FORMS AND METHODS OF USE RELATING TO 1-ETHYL-7-(2-METHYL-6-(1H-1,2,4-TRIAZOL-3-YL)PYRIDIN-3-YL)-3,4-DIHYDROPYRAZINO[2,3-b]PYRAZIN-2(1H)-ONE](/abs-image/US/2018/02/15/US20180042924A1/abs.jpg.150x150.jpg)
公开(公告)号：US20180042924A1
公开(公告)日：2018-02-15
申请号：US15790177
申请日：2017-10-23
发明人： Anil Menon , Darshan K. Parikh , Dora Visky , Matthew Michael Kreilein , Nathan Boersen , Thomas Lee , Ying Li , Jean Xu , Xiaozhang Liang , William Wei-Hwa Leong , Benjamin Cohen
IPC分类号： A61K31/4985 , A61K9/48 , A61K9/20 , C07D487/04 , C07D471/04
CPC分类号： A61K31/4985 , A61K9/2018 , A61K9/2054 , A61K9/4858 , C07D471/04 , C07D487/04
摘要： Provided herein are formulations, processes, solid forms and methods of use relating to 1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2 (1H)-one.
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