-
公开(公告)号：US5858799A
公开(公告)日：1999-01-12
申请号：US738445
申请日：1996-10-25
IPC分类号： G01N21/55 , G01N27/416
CPC分类号： G01N21/7703 , G01N21/553 , G01N27/42
摘要： This disclosure describes new methods and devices for sensing redox-active analytes in solution. The invention combines a surface plasmon resonance (SPR) sensor and a chemical electrode sensor. A conducting layer which supports SPR is attached to a voltage source. The voltage source is also connected to a reference electrode, which is in the aqueous solution with the SPR sensor. As the voltage is varied, the analytes undergo oxidation and reduction at the surface of the conducting film. The current is measured, just as it would be in a standard chemical electrode, with current peaks appearing at different potentials indicating different ions in the solution. Unlike a standard chemical electrode, the surface of the conducting film is also used to excite a surface plasmon wave (SPW). The SPW provides new information which is not available from any standard chemical electrode, such as the effective index of refraction at the surface of the conducting film as the analytes are being oxidized and/or reduced. This additional source of information can be used to minimize the effects of overlapping stripping peaks and interspecies compound formation as well as determine the thickness of surface layers during measurements. Additionally, the simultaneous determination of reaction properties and optical properties of reaction products can provide additional information about the aqueous support solution such as the quantity and types of natural oxidants in solution, such as oxygen or hydroxides. The formation of oxides and hydroxides will lead to measurably different optical properties.
摘要翻译： 本公开描述了用于在溶液中感测氧化还原活性分析物的新方法和装置。 本发明结合了表面等离子体共振（SPR）传感器和化学电极传感器。 支持SPR的导电层连接到电压源。 电压源也连接到参考电极，参考电极与SPR传感器在水溶液中。 随着电压的变化，分析物在导电膜的表面经历氧化和还原。 测量电流，就像在标准化学电极中一样，电流峰出现在不同的电位，表示溶液中的不同离子。 与标准化学电极不同，导电膜的表面也用于激发表面等离子体波（SPW）。 SPW提供了不能从任何标准化学电极获得的新信息，例如当分析物被氧化和/或还原时在导电膜的表面处的有效折射率。 这种额外的信息来源可用于最小化重叠剥离峰和种间化合物形成的影响，以及确定测量期间表面层的厚度。 此外，反应产物的反应性质和光学性质的同时测定可以提供关于水性载体溶液的附加信息，例如溶液中的天然氧化剂的量和类型，例如氧气或氢氧化物。 氧化物和氢氧化物的形成将导致可测量的不同的光学性质。
-
公开(公告)号：US06790341B1
公开(公告)日：2004-09-14
申请号：US09650075
申请日：2000-08-29
申请人： Steven Saban , Robert B. Darling , Paul Yager
发明人： Steven Saban , Robert B. Darling , Paul Yager
IPC分类号： G01N2726
CPC分类号： G01N27/42 , G01N27/27 , G01N33/1813
摘要： The present invention provides microband electrode array sensors for detecting the presence and measuring the concentration of analytes in a sample. The microband electrodes of the invention have both a width and thickness of microscopic dimensions. Preferably the width and thickness of the microbrand electrodes are less than the diffusion length of the analyte(s) of interest. In general, both the thickness and width of the electrodes are less than about 25 micrometers. The electrodes are separated by a gap insulating material that is large enough that the diffusion layers of the electrodes do not overlap such that there is no interference and the currents at the electrodes are additive. Microband electrode arrays of this invention exhibit true steady-state amperometric behavior.
摘要翻译： 本发明提供了用于检测样品中分析物的存在和测量浓度的微带电极阵列传感器。 本发明的微带电极具有微观尺寸的宽度和厚度。 优选地，微型串电极的宽度和厚度小于感兴趣的分析物的扩散长度。 通常，电极的厚度和宽度均小于约25微米。 电极被间隙绝缘材料分开，该间隙绝缘材料足够大，使得电极的扩散层不重叠，使得不存在干扰并且电极处的电流是相加的。 本发明的微带电极阵列表现出真正的稳态电流分析特性。
-
公开(公告)号：US6110354A
公开(公告)日：2000-08-29
申请号：US963678
申请日：1997-10-31
申请人： Steven Saban , Robert B. Darling , Paul Yager
发明人： Steven Saban , Robert B. Darling , Paul Yager
IPC分类号： G01N27/403 , G01N27/26
CPC分类号： G01N27/42 , G01N27/27 , G01N33/1813
摘要： The present invention provides microband electrode array sensors for detecting the presence and measuring the concentration of analytes in a sample. The microband electrodes of the invention have both a width and a thickness of microscopic dimensions. Preferably the width and thickness of the microband electrodes are less than the diffusion length of the analyte(s) of interest. In general, both the thickness and width of the electrodes are less than about 25 micrometers. The electrodes are separated by a gap insulating material that is large enough that the diffusion layers of the electrodes do not overlap such that there is no interference and the currents at the electrodes are additive. Microband electrode arrays of this invention exhibit true steady-state amperometric behavior.
摘要翻译： 本发明提供了用于检测样品中分析物的存在和测量浓度的微带电极阵列传感器。 本发明的微带电极具有微观尺寸的宽度和厚度。 优选地，微带电极的宽度和厚度小于感兴趣的分析物的扩散长度。 通常，电极的厚度和宽度均小于约25微米。 电极被间隙绝缘材料分开，该间隙绝缘材料足够大，使得电极的扩散层不重叠，使得不存在干扰并且电极处的电流是相加的。 本发明的微带电极阵列表现出真正的稳态电流分析特性。
-
公开(公告)号：US5130563A
公开(公告)日：1992-07-14
申请号：US713550
申请日：1991-06-07
IPC分类号： G06N3/067
CPC分类号： G06N3/0675
摘要： A neural network for processing sensory information. The network comprise one or more layers including interconnecting cells having individual states. Each cell is connected to one or more neighboring cells. Sensory signals and signals from interconnected neighboring cells control a current or a conductance within a cell to influence the cell's state. In some embodiments, the current or conductance of a cell can be controlled by a signal arising externally of the layer. Each cell can comprise an electrical circuit which receives an input signal and causes a current corresponding to the signal to pass through a variable conductance. The conductance is a function of the states of the one or more interconnecting neighboring cells. Proper interconnection of the cells on a layer can produce a neural network which is sensitive to predetermined patterns or the passage of such patterns across a sensor array whose signals are input into the network. The layers in the network can be made sensitive to distinct sensory parameters, so that networks which are sensitive to different wavelengths or polarizations of light energy can be produced.
摘要翻译： 一种用于处理感觉信息的神经网络。 网络包括一个或多个层，包括具有单独状态的互连单元。 每个单元连接到一个或多个相邻单元。 来自互连的相邻单元的感觉信号和信号控制单元内的电流或电导以影响单元的状态。 在一些实施例中，电池的电流或电导可以由在该层外部产生的信号来控制。 每个单元可以包括接收输入信号并且使与信号相对应的电流通过可变电导的电路。 电导是一个或多个互连相邻单元的状态的函数。 层上的单元的适当互连可以产生对预定图案敏感的神经网络或者这些图案跨过其信号被输入网络的传感器阵列的通过。 可以使网络中的层对不同的感官参数敏感，从而可以产生对不同波长或光能的偏振敏感的网络。
-
-
-
搜索结果
4 条记录 (耗时 0.033 秒)
