公开(公告)号：US10022471B2

公开(公告)日：2018-07-17

申请号：US13800694

申请日：2013-03-13

Applicant: Skeletal Kinetics, LLC

Inventor： Brent R. Constantz ,  David Delaney ,  Duran N. Yetkinler

IPC: A61L27/12

Abstract: Methods and compositions for producing flowable compositions, e.g. pastes, that set into calcium phosphate products are provided. In the subject methods, dry reactants that include a calcium source and a phosphate source are combined with a setting fluid to produce the flowable composition. A feature of the subject methods is that the dry reactants include a particulate calcium and/or phosphate reactant having a mean particle size of less than about 8 μm and narrow size distribution. Also provided are the compositions themselves as well as kits for use in practicing the subject methods. The subject methods and compositions produced thereby find use in a variety of applications, including the repair of hard tissue defects, e.g., bone defects.

公开(公告)号：US20130273118A1

公开(公告)日：2013-10-17

申请号：US13800694

申请日：2013-03-13

Applicant: Skeletal Kinetics, LLC

Inventor： Brent R. Constantz ,  David Delaney ,  Duran N. Yetkinler

IPC: A61L27/12

CPC classification number: A61L27/12 ,  Y10S514/951 ,  Y10S514/955

Abstract: Methods and compositions for producing flowable compositions, e.g. pastes, that set into calcium phosphate products are provided. In the subject methods, dry reactants that include a calcium source and a phosphate source are combined with a setting fluid to produce the flowable composition. A feature of the subject methods is that the dry reactants include a particulate calcium and/or phosphate reactant having a mean particle size of less than about 8 μm and narrow size distribution. Also provided are the compositions themselves as well as kits for use in practicing the subject methods. The subject methods and compositions produced thereby find use in a variety of applications, including the repair of hard tissue defects, e.g., bone defects.

Abstract translation: 用于生产可流动组合物的方法和组合物，例如 提供了设置成磷酸钙产品的糊剂。 在本发明方法中，包括钙源和磷酸盐源的干燥反应物与固化流体组合以产生可流动组合物。 本发明方法的特征在于干燥反应物包括平均粒径小于约8μm并具有窄尺寸分布的颗粒状钙和/或磷酸盐反应物。 还提供了组合物本身以及用于实践本发明方法的试剂盒。 由此产生的主题方法和组合物可用于各种应用，包括修复硬组织缺陷，例如骨缺损。