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    Chemoablation of tissue using biodegradable, solid salt dosage forms
    1.
    发明授权
    Chemoablation of tissue using biodegradable, solid salt dosage forms 有权
    使用可生物降解的固体盐剂型对组织进行化学消融

    公开(公告)号：US08389023B2

    公开(公告)日：2013-03-05

    申请号：US13241952

    申请日：2011-09-23

    申请人： Joseph V. DiTrolio

    发明人： Joseph V. DiTrolio

    IPC分类号： A61K33/14 ,  A61B17/42 ,  A61M5/178 ,  A61M31/00 ,  A61M25/06 ,  A61M5/315

    CPC分类号： A61K9/0024 ,  A61K33/14 ,  A61M37/0069 ,  Y10S514/951 ,  Y10S514/955 ,  Y10S514/966 ,  Y10S514/968

    摘要： Novel methods for the chemical ablation of tissue (e.g. prostatic tissue) are described. These methods include the steps of: (a) providing one or more solid salt dosage form comprising 50-100% w/w salt; and (b) inserting one or more of such solid salt dosage forms into the tissue. The solid salt dosage form is optionally inserted into the tissue under real-time ultrasonic observation. An advantage of the present invention is its ability to eliminate toxic byproducts. For example, where NaCl-based solid salt dosage forms are used to effect localized chemical ablation, the concentration is ultimately reduced to the level of normal saline (i.e., about 0.9%) upon absorption by the body of the subject being treated.

    摘要翻译： 描述了用于组织（例如前列腺组织）的化学消融的新方法。 这些方法包括以下步骤：（a）提供一种或多种包含50-100％w / w盐的固体盐剂型; 和（b）将一种或多种这样的固体盐剂型插入组织中。 在实时超声波观察下，将固体盐剂型任选地插入组织。 本发明的优点是其消除有毒副产物的能力。 例如，当使用基于NaCl的固体盐剂型来实现局部化学消融时，在被被治疗的受试者的身体吸收时，浓度最终降低到生理盐水的水平（即约0.9％）。

    Long-acting galenical formulation for GRF peptides
    3.
    发明授权
    Long-acting galenical formulation for GRF peptides 失效
    GRF肽的长效盖仑制剂

    公开(公告)号：US06194384B1

    公开(公告)日：2001-02-27

    申请号：US09135738

    申请日：1998-08-18

    申请人： Paul Brazeau ,  Denis Gravel

    发明人： Paul Brazeau ,  Denis Gravel

    IPC分类号： A61K3702

    CPC分类号： A61K9/0024 ,  A61K38/25 ,  Y10S514/955 ,  Y10S514/96

    摘要： The present invention relates to a long-acting galenical formulation of GRF peptides, GRF and/or analogs thereof which comprises about 1 to about 100 mg of a GRF peptide, fragment or analog thereof pressed from about 1 to about 100 kg/mm2 in a tablet for parenteral administration, whereby these GRF peptides are released as the tablet is eroded.

    摘要翻译： 本发明涉及GRF肽，GRF和/或其类似物的长效盖仑制剂，其包含约1至约100mg在约1至约100kg / mm 2的约1至约100kg / mm 2的压制的GRF肽，其片段或类似物 用于肠胃外给药的片剂，由此当片剂被侵蚀时，这些GRF肽被释放。

    Protein matrix materials, devices and methods of making and using thereof
    7.
    发明授权
    Protein matrix materials, devices and methods of making and using thereof 有权
    蛋白质基质材料，其制备和使用方法

    公开(公告)号：US08871267B2

    公开(公告)日：2014-10-28

    申请号：US12700896

    申请日：2010-02-05

    申请人： David B. Masters

    发明人： David B. Masters

    IPC分类号： A61K9/00 ,  A61K9/70 ,  A61K38/16 ,  A61K47/42 ,  A61L27/38 ,  A61L27/50 ,  A61L27/54 ,  A61L27/58 ,  A61L31/16 ,  A61L31/10 ,  A61L27/22

    CPC分类号： A61K9/0024 ,  A61K9/0085 ,  A61K9/7007 ,  A61K47/42 ,  A61L27/227 ,  A61L27/54 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2300/622 ,  Y10S514/95 ,  Y10S514/953 ,  Y10S514/955 ,  Y10S514/964 ,  Y10S623/915 ,  C08L89/00

    摘要： The present invention relates to protein matrix materials and devices and the methods of making and using protein matrix materials and devices. More specifically the present invention relates to protein matrix materials and devices that may be utilized for various medical applications including, but not limited to, drug delivery devices for the controlled release of pharmacologically active agents, encapsulated or coated stent devices, vessels, tubular grafts, vascular grafts, wound healing devices including protein matrix suture material and meshes, skin/bone/tissue grafts, biocompatible electricity conducting matrices, clear protein matrices, protein matrix adhesion prevention barriers, cell scaffolding and other biocompatible protein matrix devices. Furthermore, the present invention relates to protein matrix materials and devices made by forming a film comprising one or more biodegradable protein materials, one or more biocompatible solvents and optionally one or more pharmacologically active agents. The film is then partially dried, rolled or otherwise shaped, and then compressed to form the desired protein matrix device.

    摘要翻译： 本发明涉及蛋白质基质材料和装置，以及制备和使用蛋白质基质材料和装置的方法。 更具体地，本发明涉及可用于各种医学应用的蛋白质基质材料和装置，包括但不限于用于药理学活性剂的控制释放的药物递送装置，包封的或涂覆的支架装置，血管，管状移植物， 血管移植物，伤口愈合装置，包括蛋白质基质缝合材料和网眼，皮肤/骨/组织移植物，生物相容导电基质，透明蛋白质基质，蛋白质基质粘附防止屏障，细胞支架和其他生物相容性蛋白质基质装置。 此外，本发明涉及通过形成包含一种或多种可生物降解的蛋白质材料，一种或多种生物相容性溶剂和任选的一种或多种药理学活性剂的膜制备的蛋白质基质材料和装置。 然后将膜部分干燥，滚动或以其他方式成形，然后压缩以形成所需的蛋白质基质装置。

    CHEMOABLATION OF TISSUE USING BIODEGRADABLE, SOLID SALT DOSAGE FORMS
    8.
    发明申请
    CHEMOABLATION OF TISSUE USING BIODEGRADABLE, SOLID SALT DOSAGE FORMS 有权
    使用生物可降解的固体盐剂型进行组织化学

    公开(公告)号：US20120016338A1

    公开(公告)日：2012-01-19

    申请号：US13241952

    申请日：2011-09-23

    申请人： Joseph V. DiTrolio

    发明人： Joseph V. DiTrolio

    IPC分类号： A61M5/31 ,  A61M5/00 ,  A61K9/14 ,  A61P35/00 ,  A61K33/14 ,  A61K9/00

    CPC分类号： A61K9/0024 ,  A61K33/14 ,  A61M37/0069 ,  Y10S514/951 ,  Y10S514/955 ,  Y10S514/966 ,  Y10S514/968

    摘要： Novel methods for the chemical ablation of tissue (e.g. prostatic tissue) are described. These methods include the steps of: (a) providing one or more solid salt dosage form comprising 50-100% w/w salt; and (b) inserting one or more of such solid salt dosage forms into the tissue. The solid salt dosage form is optionally inserted into the tissue under real-time ultrasonic observation. An advantage of the present invention is its ability to eliminate toxic byproducts. For example, where NaCl-based solid salt dosage forms are used to effect localized chemical ablation, the concentration is ultimately reduced to the level of normal saline (i.e., about 0.9%) upon absorption by the body of the subject being treated.

    摘要翻译： 描述了用于组织（例如前列腺组织）的化学消融的新方法。 这些方法包括以下步骤：（a）提供一种或多种包含50-100％w / w盐的固体盐剂型; 和（b）将一种或多种这样的固体盐剂型插入组织中。 在实时超声波观察下，将固体盐剂型任选地插入组织。 本发明的优点是其消除有毒副产物的能力。 例如，当使用基于NaCl的固体盐剂型来实现局部化学消融时，在被被治疗的受试者的身体吸收时，浓度最终降低到生理盐水的水平（即约0.9％）。

    Chemoablation of tissue using biodegradable, solid salt dosage forms
    10.
    发明授权
    Chemoablation of tissue using biodegradable, solid salt dosage forms 有权
    使用可生物降解的固体盐剂型对组织进行化学消融

    公开(公告)号：US07226622B2

    公开(公告)日：2007-06-05

    申请号：US10940589

    申请日：2004-09-14

    申请人： Joseph V. DiTrolio

    发明人： Joseph V. DiTrolio

    IPC分类号： A61K33/14 ,  A61F13/00 ,  A61F2/00 ,  A01N59/08

    CPC分类号： A61K9/0024 ,  A61K33/14 ,  A61M37/0069 ,  Y10S514/951 ,  Y10S514/955 ,  Y10S514/966 ,  Y10S514/968

    摘要： Novel methods for the chemical ablation of tissue (e.g. prostatic tissue) are described. These methods include the steps of: (a) providing one or more solid salt dosage form comprising 50-100% w/w salt; and (b) inserting one or more of such solid salt dosage forms into the tissue. The solid salt dosage form is optionally inserted into the tissue under real-time ultrasonic observation. An advantage of the present invention is its ability to eliminate toxic byproducts. For example, where NaCl-based solid salt dosage forms are used to effect localized chemical ablation, the concentration is ultimately reduced to the level of normal saline (i.e., about 0.9%) upon absorption by the body of the subject being treated.

    摘要翻译： 描述了用于组织（例如前列腺组织）的化学消融的新方法。 这些方法包括以下步骤：（a）提供一种或多种包含50-100％w / w盐的固体盐剂型; 和（b）将一种或多种这样的固体盐剂型插入组织中。 在实时超声波观察下，将固体盐剂型任选地插入组织。 本发明的优点是其消除有毒副产物的能力。 例如，当使用基于NaCl的固体盐剂型来实现局部化学消融时，在被被治疗的受试者的身体吸收时，浓度最终降低到生理盐水的水平（即约0.9％）。