公开(公告)号：US12257348B2

公开(公告)日：2025-03-25

申请号：US17327724

申请日：2021-05-23

Applicant: Sol-Gel Technologies Ltd.

Inventor： Ofer Toledano ,  Karine Neimann ,  Danil Finkel-Moiseev ,  Maya Erlich ,  Dorit Marco

IPC: A61K9/48 ,  A61K9/00 ,  A61K9/50 ,  A61K31/202 ,  A61K31/203 ,  A61K31/235 ,  A61K31/327 ,  A61K31/336

Abstract: The present application is directed to stabilized core-shell microcapsules comprising a core of benzoyl peroxide (BPO) or all trans retinoic acid (ATRA) and a metal-oxide shell; and to pharmaceutical compositions and methods of use thereof.

公开(公告)号：US20190015366A1

公开(公告)日：2019-01-17

申请号：US16033260

申请日：2018-07-12

Applicant: SOL-GEL TECHNOLOGIES LTD.

Inventor： Ofer TOLEDANO ,  Karine Neimann ,  Maya Erlich ,  Dorit Marco

IPC: A61K31/202 ,  A61K9/50 ,  A61K9/00 ,  A61K9/107 ,  A61K9/06

Abstract: The present application is directed to compositions comprising microcapsules comprising encapsulated tretinoin, wherein the microcapsule size is less than 50 μm; and to methods of use thereof.

公开(公告)号：US12133919B2

公开(公告)日：2024-11-05

申请号：US17327729

申请日：2021-05-23

Applicant: Sol-Gel Technologies Ltd.

Inventor： Ofer Toledano ,  Karine Neimann ,  Danil Finkel-Moiseev ,  Maya Erlich ,  Dorit Marco

IPC: A61K9/48 ,  A61K9/00 ,  A61K9/50 ,  A61K31/202 ,  A61K31/203 ,  A61K31/235 ,  A61K31/327 ,  A61K31/336

Abstract: The present application is directed to stabilized core-shell microcapsules comprising a core of benzoyl peroxide (BPO) or all trans retinoic acid (ATRA) and a metal-oxide shell; and to pharmaceutical compositions and methods of use thereof.

公开(公告)号：US20210361586A1

公开(公告)日：2021-11-25

申请号：US17327724

申请日：2021-05-23

Applicant: Sol-Gel Technologies Ltd.

Inventor： Ofer Toledano ,  Karine Neimann ,  Danil Finkel-Moiseev ,  Maya Erlich ,  Dorit MARCO

IPC: A61K9/50 ,  A61K31/327 ,  A61K31/203 ,  A61K9/00

Abstract: The present application is directed to stabilized core-shell microcapsules comprising a core of benzoyl peroxide (BPO) or all trans retinoic acid (ATRA) and a metal-oxide shell; and to pharmaceutical compositions and methods of use thereof.