公开(公告)号：US12257348B2

公开(公告)日：2025-03-25

申请号：US17327724

申请日：2021-05-23

Applicant: Sol-Gel Technologies Ltd.

Inventor： Ofer Toledano ,  Karine Neimann ,  Danil Finkel-Moiseev ,  Maya Erlich ,  Dorit Marco

IPC: A61K9/48 ,  A61K9/00 ,  A61K9/50 ,  A61K31/202 ,  A61K31/203 ,  A61K31/235 ,  A61K31/327 ,  A61K31/336

Abstract: The present application is directed to stabilized core-shell microcapsules comprising a core of benzoyl peroxide (BPO) or all trans retinoic acid (ATRA) and a metal-oxide shell; and to pharmaceutical compositions and methods of use thereof.

公开(公告)号：US12133919B2

公开(公告)日：2024-11-05

申请号：US17327729

申请日：2021-05-23

Applicant: Sol-Gel Technologies Ltd.

Inventor： Ofer Toledano ,  Karine Neimann ,  Danil Finkel-Moiseev ,  Maya Erlich ,  Dorit Marco

IPC: A61K9/48 ,  A61K9/00 ,  A61K9/50 ,  A61K31/202 ,  A61K31/203 ,  A61K31/235 ,  A61K31/327 ,  A61K31/336

Abstract: The present application is directed to stabilized core-shell microcapsules comprising a core of benzoyl peroxide (BPO) or all trans retinoic acid (ATRA) and a metal-oxide shell; and to pharmaceutical compositions and methods of use thereof.

公开(公告)号：US11865100B2

公开(公告)日：2024-01-09

申请号：US17154689

申请日：2021-01-21

Applicant: Sol-Gel Technologies Ltd.

Inventor： Ofer Toledano ,  Ofra Levy-Hacham ,  Ori Nov ,  Vered Ram

IPC: A61K31/327 ,  A61P17/10 ,  A61K9/00 ,  A61K9/06 ,  A61K9/107 ,  A61P17/00 ,  A61K9/50 ,  A61K9/10

CPC classification number: A61K31/327 ,  A61K9/0014 ,  A61K9/06 ,  A61K9/10 ,  A61K9/107 ,  A61K9/50 ,  A61P17/00 ,  A61P17/10

Abstract: A regimen for the therapeutic treatment of rosacea in subjects aged 65 years and older, the regimen comprising topically applying to the skin of a subject aged 65 years and older in need of said treatment a pharmaceutical composition, the pharmaceutical composition comprising about 1% w/w to about 10% w/w benzoyl peroxide as an active ingredient, and a pharmaceutically acceptable carrier or excipient, wherein the benzoyl peroxide is the only active ingredient in said pharmaceutical composition, wherein said pharmaceutical composition is applied once daily for a period of at least about 2 weeks, to achieve, in a group of such subjects, a success rate of at least about 15%, wherein the success rate is defined as the number of subjects achieving clear or almost clear skin on the investor global assessment (IGA) scale after treatment with the pharmaceutical composition.

公开(公告)号：US20210361586A1

公开(公告)日：2021-11-25

申请号：US17327724

申请日：2021-05-23

Applicant: Sol-Gel Technologies Ltd.

Inventor： Ofer Toledano ,  Karine Neimann ,  Danil Finkel-Moiseev ,  Maya Erlich ,  Dorit MARCO

IPC: A61K9/50 ,  A61K31/327 ,  A61K31/203 ,  A61K9/00

Abstract: The present application is directed to stabilized core-shell microcapsules comprising a core of benzoyl peroxide (BPO) or all trans retinoic acid (ATRA) and a metal-oxide shell; and to pharmaceutical compositions and methods of use thereof.

公开(公告)号：US10653899B2

公开(公告)日：2020-05-19

申请号：US16052635

申请日：2018-08-02

Applicant: SOL-GEL TECHNOLOGIES LTD.

Inventor： Ofer Toledano ,  Haim Bar-Simantov ,  Hanan Sertchook ,  Sharon Fireman-Shoresh ,  Dorit Marco

IPC: A01N25/28 ,  A61Q19/00 ,  B01J13/14 ,  A61K9/51 ,  A61K9/00 ,  A61K8/67 ,  A61K8/38 ,  A61K8/26 ,  A61K8/25 ,  A61K8/11 ,  A61K9/50 ,  A61K9/06 ,  A61K8/28 ,  A61K8/29 ,  A61K8/27 ,  A61K8/73 ,  A61K47/02 ,  A61K8/06 ,  F28D20/02

Abstract: The present invention provides core-stabilized microcapsules, wherein said core comprises at least one active agent encapsulated within an inorganic oxide shell, processes for their preparations, comparisons comprising them and uses thereof.

公开(公告)号：US10420743B2

公开(公告)日：2019-09-24

申请号：US16033257

申请日：2018-07-12

Applicant: SOL-GEL TECHNOLOGIES LTD.

Inventor： Ofer Toledano ,  Ori Nov

IPC: A61K9/50 ,  A61K31/203 ,  A61K31/327 ,  A61P17/10 ,  A61K9/00

Abstract: The present application is directed to regimens, methods of treatment, and compositions for the treatment of acne in a subject suffering therefrom.

公开(公告)号：US20180117369A1

公开(公告)日：2018-05-03

申请号：US15834805

申请日：2017-12-07

Applicant: SOL-GEL TECHNOLOGIES LTD.

Inventor： Ofer Toledano ,  Haim Bar-Simantov ,  Hanan Sertchook ,  Sharon Fireman-Shoresh ,  Dorit Marco

IPC: A61Q19/00 ,  B01J13/14 ,  A61K9/51 ,  A61K8/11 ,  A61K8/67 ,  A61K8/38 ,  A61K8/26 ,  A61K8/25 ,  A61K9/00

CPC classification number: A61Q19/00 ,  A61K8/11 ,  A61K8/25 ,  A61K8/26 ,  A61K8/38 ,  A61K8/671 ,  A61K9/0014 ,  A61K9/5115 ,  A61K9/5192 ,  A61K2800/412 ,  B01J13/14

Abstract: The present invention provides core-stabilized microcapsules, wherein said core comprises at least one active agent encapsulated within a metal oxide shell, processes for their preparations, comparisons comprising them and uses thereof.

公开(公告)号：US11628155B2

公开(公告)日：2023-04-18

申请号：US16794692

申请日：2020-02-19

Applicant: Sol-Gel Technologies Ltd.

Inventor： Ofer Toledano ,  Ori Nov

IPC: A61K31/327 ,  A61P17/10 ,  A61K9/00 ,  A61K9/06 ,  A61K9/107 ,  A61P17/00 ,  A61K9/50 ,  A61K9/10

Abstract: A regimen and a pharmaceutical composition for the treatment of rosacea are described. The regimen includes topically applying to the skin of a subject in need of such treatment a pharmaceutical composition comprising about 1% w/w to about 10% w/w benzoyl peroxide as an active ingredient, and the pharmaceutically acceptable carrier or excipient, where the benzoyl peroxide is the only active ingredient in the pharmaceutical composition, and the pharmaceutical composition is a cream or an emulsion.

公开(公告)号：US20210290985A1

公开(公告)日：2021-09-23

申请号：US17340334

申请日：2021-06-07

Applicant: Sol-Gel Technologies Ltd.

Inventor： Ofer Toledano ,  Haim Bar-Simantov ,  Hanan Sertchook ,  Sharon Fireman-Shoresh ,  Dorit Marco

IPC: A61Q19/00 ,  B01J13/14 ,  A61K9/51 ,  A61K9/00 ,  A61K8/67 ,  A61K8/38 ,  A61K8/26 ,  A61K8/25 ,  A61K8/11 ,  A61K9/06 ,  A61K9/50 ,  B01J13/18 ,  F28D20/02 ,  A61K9/10

Abstract: The present invention provides core-stabilized microcapsules, wherein said core comprises at least one active agent encapsulated within an inorganic oxide shell, processes for their preparations, comparisons comprising them and uses thereof.

公开(公告)号：US20200316005A1

公开(公告)日：2020-10-08

申请号：US16897308

申请日：2020-06-10

Applicant: SOL-GEL TECHNOLOGIES LTD.

Inventor： Ofer Toledano ,  Ori Nov

IPC: A61K31/203 ,  A61K9/00 ,  A61P17/10 ,  A61K9/50 ,  A61K31/327

Abstract: The present application is directed to regimens, methods of treatment, and compositions for the treatment of acne in a subject suffering therefrom.