公开(公告)号：US11071878B2

公开(公告)日：2021-07-27

申请号：US15924331

申请日：2018-03-19

Applicant: SOL-GEL TECHNOLOGIES LTD.

Inventor： Ofer Toledano ,  Haim Bar-Simantov ,  Hanan Sertchook ,  Sharon Fireman-Shoresh ,  Dorit Marco

IPC: A61Q19/00 ,  B01J13/14 ,  A61K9/51 ,  A61K9/00 ,  A61K8/67 ,  A61K8/38 ,  A61K8/26 ,  A61K8/25 ,  A61K8/11 ,  A61K9/06 ,  A61K9/50 ,  B01J13/18 ,  F28D20/02 ,  A61K9/10 ,  A61K47/38 ,  A61K47/32

Abstract: The present invention provides core-stabilized microcapsules, wherein said core comprises at least one active agent encapsulated within an inorganic oxide shell, processes for their preparations, comparisons comprising them and uses thereof.

公开(公告)号：US12070629B2

公开(公告)日：2024-08-27

申请号：US17340334

申请日：2021-06-07

Applicant: Sol-Gel Technologies Ltd.

Inventor： Ofer Toledano ,  Haim Bar-Simantov ,  Hanan Sertchook ,  Sharon Fireman-Shoresh ,  Dorit Marco

IPC: A61Q19/00 ,  A61K8/11 ,  A61K8/25 ,  A61K8/26 ,  A61K8/38 ,  A61K8/67 ,  A61K9/00 ,  A61K9/06 ,  A61K9/10 ,  A61K9/50 ,  A61K9/51 ,  B01J13/14 ,  B01J13/18 ,  F28D20/02 ,  A61K47/32 ,  A61K47/38

CPC classification number: A61Q19/00 ,  A61K8/11 ,  A61K8/25 ,  A61K8/26 ,  A61K8/38 ,  A61K8/671 ,  A61K9/0014 ,  A61K9/06 ,  A61K9/10 ,  A61K9/501 ,  A61K9/5115 ,  A61K9/5192 ,  B01J13/14 ,  B01J13/18 ,  F28D20/023 ,  A61K9/5026 ,  A61K47/32 ,  A61K47/38 ,  A61K2800/412

Abstract: The present invention provides core-stabilized microcapsules, wherein said core comprises at least one active agent encapsulated within an inorganic oxide shell, processes for their preparations, comparisons comprising them and uses thereof.

公开(公告)号：US12257348B2

公开(公告)日：2025-03-25

申请号：US17327724

申请日：2021-05-23

Applicant: Sol-Gel Technologies Ltd.

Inventor： Ofer Toledano ,  Karine Neimann ,  Danil Finkel-Moiseev ,  Maya Erlich ,  Dorit Marco

IPC: A61K9/48 ,  A61K9/00 ,  A61K9/50 ,  A61K31/202 ,  A61K31/203 ,  A61K31/235 ,  A61K31/327 ,  A61K31/336

Abstract: The present application is directed to stabilized core-shell microcapsules comprising a core of benzoyl peroxide (BPO) or all trans retinoic acid (ATRA) and a metal-oxide shell; and to pharmaceutical compositions and methods of use thereof.

公开(公告)号：US12133919B2

公开(公告)日：2024-11-05

申请号：US17327729

申请日：2021-05-23

Applicant: Sol-Gel Technologies Ltd.

Inventor： Ofer Toledano ,  Karine Neimann ,  Danil Finkel-Moiseev ,  Maya Erlich ,  Dorit Marco

IPC: A61K9/48 ,  A61K9/00 ,  A61K9/50 ,  A61K31/202 ,  A61K31/203 ,  A61K31/235 ,  A61K31/327 ,  A61K31/336

Abstract: The present application is directed to stabilized core-shell microcapsules comprising a core of benzoyl peroxide (BPO) or all trans retinoic acid (ATRA) and a metal-oxide shell; and to pharmaceutical compositions and methods of use thereof.

公开(公告)号：US10653899B2

公开(公告)日：2020-05-19

申请号：US16052635

申请日：2018-08-02

Applicant: SOL-GEL TECHNOLOGIES LTD.

Inventor： Ofer Toledano ,  Haim Bar-Simantov ,  Hanan Sertchook ,  Sharon Fireman-Shoresh ,  Dorit Marco

IPC: A01N25/28 ,  A61Q19/00 ,  B01J13/14 ,  A61K9/51 ,  A61K9/00 ,  A61K8/67 ,  A61K8/38 ,  A61K8/26 ,  A61K8/25 ,  A61K8/11 ,  A61K9/50 ,  A61K9/06 ,  A61K8/28 ,  A61K8/29 ,  A61K8/27 ,  A61K8/73 ,  A61K47/02 ,  A61K8/06 ,  F28D20/02

Abstract: The present invention provides core-stabilized microcapsules, wherein said core comprises at least one active agent encapsulated within an inorganic oxide shell, processes for their preparations, comparisons comprising them and uses thereof.

公开(公告)号：US20180117369A1

公开(公告)日：2018-05-03

申请号：US15834805

申请日：2017-12-07

Applicant: SOL-GEL TECHNOLOGIES LTD.

Inventor： Ofer Toledano ,  Haim Bar-Simantov ,  Hanan Sertchook ,  Sharon Fireman-Shoresh ,  Dorit Marco

IPC: A61Q19/00 ,  B01J13/14 ,  A61K9/51 ,  A61K8/11 ,  A61K8/67 ,  A61K8/38 ,  A61K8/26 ,  A61K8/25 ,  A61K9/00

CPC classification number: A61Q19/00 ,  A61K8/11 ,  A61K8/25 ,  A61K8/26 ,  A61K8/38 ,  A61K8/671 ,  A61K9/0014 ,  A61K9/5115 ,  A61K9/5192 ,  A61K2800/412 ,  B01J13/14

Abstract: The present invention provides core-stabilized microcapsules, wherein said core comprises at least one active agent encapsulated within a metal oxide shell, processes for their preparations, comparisons comprising them and uses thereof.

公开(公告)号：US20210290985A1

公开(公告)日：2021-09-23

申请号：US17340334

申请日：2021-06-07

Applicant: Sol-Gel Technologies Ltd.

Inventor： Ofer Toledano ,  Haim Bar-Simantov ,  Hanan Sertchook ,  Sharon Fireman-Shoresh ,  Dorit Marco

IPC: A61Q19/00 ,  B01J13/14 ,  A61K9/51 ,  A61K9/00 ,  A61K8/67 ,  A61K8/38 ,  A61K8/26 ,  A61K8/25 ,  A61K8/11 ,  A61K9/06 ,  A61K9/50 ,  B01J13/18 ,  F28D20/02 ,  A61K9/10

Abstract: The present invention provides core-stabilized microcapsules, wherein said core comprises at least one active agent encapsulated within an inorganic oxide shell, processes for their preparations, comparisons comprising them and uses thereof.

公开(公告)号：US20190015366A1

公开(公告)日：2019-01-17

申请号：US16033260

申请日：2018-07-12

Applicant: SOL-GEL TECHNOLOGIES LTD.

Inventor： Ofer TOLEDANO ,  Karine Neimann ,  Maya Erlich ,  Dorit Marco

IPC: A61K31/202 ,  A61K9/50 ,  A61K9/00 ,  A61K9/107 ,  A61K9/06

Abstract: The present application is directed to compositions comprising microcapsules comprising encapsulated tretinoin, wherein the microcapsule size is less than 50 μm; and to methods of use thereof.