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公开(公告)号：US20200376109A1
公开(公告)日：2020-12-03
申请号：US16879668
申请日：2020-05-20
发明人： Oreola Donini , Axel Lehrer
摘要： Disclosed is a stable immunogenic composition capable of eliciting a robust and durable immune response, comprising at least one antigen consisting of a filovirus glycoprotein and at least one nano-emulsion adjuvant which are co-lyophilized and can be reconstituted immediately prior to use. Also disclosed is a vaccine composition comprising at least two antigens, wherein each antigen is specific to a different genus of filovirus and which also comprises at least one nano-emulsion adjuvant.
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2.发明公开公开(公告)号：US20240009297A1
公开(公告)日：2024-01-11
申请号：US18017752
申请日：2021-07-26
发明人： Oreola Donini , Axel Lehrer
IPC分类号： A61K39/215 , A61K39/39 , A61P31/14
CPC分类号： A61K39/215 , A61K39/39 , A61P31/14 , A61K2039/55583
摘要： Recombinant vaccine compositions combined with a specified adjuvant to deliver a robust immune response against coronaviruses for inducing protective immunity to a coronavirus comprising providing a stable immunogenic composition capable of eliciting a robust and durable immune response to the coronavirus, wherein the composition comprises a protein subunit comprising a recombinant protein specific to the coronavirus and at least one adjuvant.
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公开(公告)号：US11433129B2
公开(公告)日：2022-09-06
申请号：US16879668
申请日：2020-05-20
发明人： Oreola Donini , Axel Lehrer
摘要： Disclosed is a stable immunogenic composition capable of eliciting a robust and durable immune response, comprising at least one antigen consisting of a filovirus glycoprotein and at least one nano-emulsion adjuvant which are co-lyophilized and can be reconstituted immediately prior to use. Also disclosed is a vaccine composition comprising at least two antigens, wherein each antigen is specific to a different genus of filovirus and which also comprises at least one nano-emulsion adjuvant.
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公开(公告)号：US20240189413A1
公开(公告)日：2024-06-13
申请号：US18376177
申请日：2023-10-03
发明人： Oreola Donini , Axel Lehrer
CPC分类号： A61K39/12 , A61K39/39 , A61P31/14 , C12N7/00 , A61K2039/55566 , A61K2039/575 , A61K2039/70
摘要： Disclosed is a stable immunogenic composition capable of eliciting a robust and durable immune response, comprising at least one antigen consisting of a filovirus glycoprotein and at least one nano-emulsion adjuvant which are co-lyophilized and can be reconstituted immediately prior to use. Also disclosed is a vaccine composition comprising at least two antigens, wherein each antigen is specific to a different genus of filovirus and which also comprises at least one nano-emulsion adjuvant.
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公开(公告)号：US11771757B2
公开(公告)日：2023-10-03
申请号：US17902662
申请日：2022-09-02
发明人： Oreola Donini , Axel Lehrer
CPC分类号： A61K39/12 , A61K39/39 , A61P31/14 , C12N7/00 , A61K2039/55566 , A61K2039/575 , A61K2039/70
摘要： Disclosed is a stable immunogenic composition capable of eliciting a robust and durable immune response, comprising at least one antigen consisting of a filovirus glycoprotein and at least one nano-emulsion adjuvant which are co-lyophilized and can be reconstituted immediately prior to use. Also disclosed is a vaccine composition comprising at least two antigens, wherein each antigen is specific to a different genus of filovirus and which also comprises at least one nano-emulsion adjuvant.
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公开(公告)号：US20230093418A1
公开(公告)日：2023-03-23
申请号：US17902662
申请日：2022-09-02
发明人： Oreola Donini , Axel Lehrer
摘要： Disclosed is a stable immunogenic composition capable of eliciting a robust and durable immune response, comprising at least one antigen consisting of a filovirus glycoprotein and at least one nano-emulsion adjuvant which are co-lyophilized and can be reconstituted immediately prior to use. Also disclosed is a vaccine composition comprising at least two antigens, wherein each antigen is specific to a different genus of filovirus and which also comprises at least one nano-emulsion adjuvant.
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