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1.发明公开公开(公告)号：US20240009297A1
公开(公告)日：2024-01-11
申请号：US18017752
申请日：2021-07-26
发明人： Oreola Donini , Axel Lehrer
IPC分类号： A61K39/215 , A61K39/39 , A61P31/14
CPC分类号： A61K39/215 , A61K39/39 , A61P31/14 , A61K2039/55583
摘要： Recombinant vaccine compositions combined with a specified adjuvant to deliver a robust immune response against coronaviruses for inducing protective immunity to a coronavirus comprising providing a stable immunogenic composition capable of eliciting a robust and durable immune response to the coronavirus, wherein the composition comprises a protein subunit comprising a recombinant protein specific to the coronavirus and at least one adjuvant.
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公开(公告)号：US12097291B2
公开(公告)日：2024-09-24
申请号：US17316585
申请日：2021-05-10
IPC分类号： A61K39/395 , A61K9/19 , A61K39/00 , A61K39/39 , A61K47/26
CPC分类号： A61K9/19 , A61K39/00 , A61K39/39 , A61K47/26 , A61K2039/55505 , A61K2039/55572 , Y02A50/30
摘要： Compositions relating to thermostable vaccines and methods of preparing the same. Specifically, methods of preparing thermostable vaccines based on a recombinant ricin neurotoxin protein and uses of co-adjuvants to develop a composition capable of eliciting an immune response in a subject.
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公开(公告)号：US20210361579A1
公开(公告)日：2021-11-25
申请号：US17316585
申请日：2021-05-10
摘要： Compositions relating to thermostable vaccines and methods of preparing the same. Specifically, methods of preparing thermostable vaccines based on a recombinant ricin neurotoxin protein and uses of co-adjuvants to develop a composition capable of eliciting an immune response in a subject.
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公开(公告)号：US20240189413A1
公开(公告)日：2024-06-13
申请号：US18376177
申请日：2023-10-03
发明人： Oreola Donini , Axel Lehrer
CPC分类号： A61K39/12 , A61K39/39 , A61P31/14 , C12N7/00 , A61K2039/55566 , A61K2039/575 , A61K2039/70
摘要： Disclosed is a stable immunogenic composition capable of eliciting a robust and durable immune response, comprising at least one antigen consisting of a filovirus glycoprotein and at least one nano-emulsion adjuvant which are co-lyophilized and can be reconstituted immediately prior to use. Also disclosed is a vaccine composition comprising at least two antigens, wherein each antigen is specific to a different genus of filovirus and which also comprises at least one nano-emulsion adjuvant.
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公开(公告)号：US20230024050A1
公开(公告)日：2023-01-26
申请号：US17860599
申请日：2022-07-08
申请人： Soligenix, Inc.
IPC分类号： A61K31/122 , A61K41/00 , A61N5/06
摘要： A method of treating CTCL comprising applying a combination of an effective amount of hypericin together with a form of visible light photodynamic therapy. Preferably, the effective amount of hypericin is an ointment comprising less than 1% hypericin. More preferably, the form of photodynamic therapy comprises an administration of escalating doses of visible light. Optionally, the escalating doses of visible light starts at about 5 J/cm2 and increases to a maximum dose of about 12 J/cm2.
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公开(公告)号：US20200376109A1
公开(公告)日：2020-12-03
申请号：US16879668
申请日：2020-05-20
发明人： Oreola Donini , Axel Lehrer
摘要： Disclosed is a stable immunogenic composition capable of eliciting a robust and durable immune response, comprising at least one antigen consisting of a filovirus glycoprotein and at least one nano-emulsion adjuvant which are co-lyophilized and can be reconstituted immediately prior to use. Also disclosed is a vaccine composition comprising at least two antigens, wherein each antigen is specific to a different genus of filovirus and which also comprises at least one nano-emulsion adjuvant.
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公开(公告)号：US20200155571A1
公开(公告)日：2020-05-21
申请号：US16448526
申请日：2019-06-21
申请人： Soligenix, Inc.
IPC分类号： A61K31/573 , A61K33/00 , A61K45/06 , A61K38/17 , A61K38/18
摘要： Methods of delivering corticosteroids or metabolites thereof for treating and preventing tissue damage resulting from acute radiation injury in the gastrointestinal tract with locally effective therapeutic agents.
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公开(公告)号：US10526268B2
公开(公告)日：2020-01-07
申请号：US16107047
申请日：2018-08-21
申请人： Soligenix, Inc.
IPC分类号： C07C46/10
摘要： Improved systems and methods for producing synthetic hypericin at high volume and high purity. In particular, systems and methods of preparing a purified synthetic hypericin resulting from irradiation, wherein the irradiation step is performed in a continuous flow micro-reactor. The process of manufacturing purified synthetic hypericin results in the synthetic yield of 30-100% of the dry product.
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公开(公告)号：US20190135724A1
公开(公告)日：2019-05-09
申请号：US16107047
申请日：2018-08-21
申请人： Soligenix, Inc.
IPC分类号： C07C46/10
CPC分类号： C07C46/10 , C07C2603/54 , C07C50/36
摘要： Improved systems and methods for producing synthetic hypericin at high volume and high purity.
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公开(公告)号：US20170333448A1
公开(公告)日：2017-11-23
申请号：US15495798
申请日：2017-04-24
申请人： Soligenix, Inc.
IPC分类号： A61K31/573 , A61K38/18 , A61K38/17 , A61K45/06 , A61K33/00
CPC分类号： A61K31/573 , A61K33/00 , A61K38/1709 , A61K38/1825 , A61K45/06 , A61K2300/00
摘要： Methods of delivering corticosteroids or metabolites thereof for treating and preventing tissue damage resulting from acute radiation injury in the gastrointestinal tract with locally effective therapeutic agents.
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