公开(公告)号：US20240300947A1

公开(公告)日：2024-09-12

申请号：US18665823

申请日：2024-05-16

Applicant: Solventum Intellectual Properties Company

Inventor： George W. Griesgraber ,  Bryon A. Merrill ,  Michael J. Rice

IPC: C07D471/04 ,  A61K31/4745 ,  A61P37/04

CPC classification number: C07D471/04 ,  A61K31/4745 ,  A61P37/04

Abstract: Imidazo[4,5-c]quinoline compounds having a substituent that is attached at the N-1 position by a branched group, single enantiomers of the compounds, pharmaceutical compositions containing the compounds, and methods of making the compounds are disclosed. Methods of use of the compounds as immune response modifiers, for inducing cytokine biosynthesis in humans and animals, and in the treatment of diseases including infectious and neoplastic diseases are also disclosed.

公开(公告)号：US12024514B2

公开(公告)日：2024-07-02

申请号：US17309216

申请日：2019-11-11

Applicant: Solventum Intellectual Properties Company

Inventor： George W. Griesgraber ,  Bryon A. Merrill ,  Michael J. Rice

IPC: C07D471/04 ,  A61K31/4745 ,  A61P37/04

CPC classification number: C07D471/04 ,  A61K31/4745 ,  A61P37/04

Abstract: Imidazo[4,5-c]quinoline compounds having a substituent that is attached at the N−1 position by a branched group, single enantiomers of the compounds, pharmaceutical compositions containing the compounds, and methods of making the compounds are disclosed. Methods of use of the compounds as immune response modifiers, for inducing cytokine biosynthesis in humans and animals, and in the treatment of diseases including infectious and neoplastic diseases are also disclosed.

公开(公告)号：US12064730B2

公开(公告)日：2024-08-20

申请号：US15733205

申请日：2018-12-14

Applicant: Solventum Intellectual Properties Company

Inventor： Jerald K. Rasmussen ,  Stephen B. Roscoe ,  Babu N. Gaddam ,  George W. Griesgraber ,  Daniel J. O'Neal ,  Eli P. Narveson

IPC: B01D67/00 ,  B01D69/02 ,  B01D69/10 ,  C08J7/18 ,  C12M1/00 ,  G01N33/543 ,  G01N33/545

CPC classification number: B01D67/0006 ,  B01D67/00931 ,  B01D69/02 ,  B01D69/105 ,  B01D69/1071 ,  C08J7/18 ,  C12M29/04 ,  G01N33/54393 ,  G01N33/545 ,  B01D2323/38 ,  C08J2377/02

Abstract: Articles with covalently attached thiocarbonylthio-containing groups are provided. More specifically, the articles include a solid polymeric substrate with a plurality of thiocarbonylthio-containing groups covalently attached directly to a carbon atom in a polymeric backbone of the solid polymeric substrate. Methods of making the articles with covalently attached thiocarbonylthio-containing are provided. Additionally, methods of using these articles to generate further articles with covalently attached polymeric chains are provided.