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1.发明申请NANOPARTICLES BASED ON GADOLIIUM COORDINATION POLYMERS AS HIGHLY SENSITIVE T1 MRI CONTRAST AGENTS 有权基于GADOLIIUM协调聚合物的纳米粒子作为敏感性T1 MRI对比剂公开(公告)号：US20130209369A1
公开(公告)日：2013-08-15
申请号：US13819018
申请日：2011-09-08
IPC分类号： A61K49/08
摘要： An agent for imaging of a biological system or delivering drugs to a biological system including one or more nanoparticles formed of at least one gadolinium coordination polymer.
摘要翻译： 用于生物系统成像或将药物递送到包括由至少一种钆配位聚合物形成的一种或多种纳米颗粒的生物系统的试剂。
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2.发明授权Nanoparticles based on gadolinium coordination polymers as highly sensitive T1 MRI contrast agents 有权基于钆配位聚合物的纳米颗粒作为高灵敏度T1 MRI造影剂公开(公告)号：US08940275B2
公开(公告)日：2015-01-27
申请号：US13819018
申请日：2011-09-08
摘要： An agent for imaging of a biological system or delivering drugs to a biological system including one or more nanoparticles formed of at least one gadolinium coordination polymer.
摘要翻译： 用于生物系统成像或将药物递送到包括由至少一种钆配位聚合物形成的一种或多种纳米颗粒的生物系统的试剂。
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3.发明申请Gadolinium containing prussian blue nanoparticles as nontoxic MRI contrast agents having high relaxivity 有权含有普鲁士蓝色纳米粒子的钆，作为具有高弛豫性的无毒的MRI造影剂公开(公告)号：US20100254912A1
公开(公告)日：2010-10-07
申请号：US12384391
申请日：2009-04-03
CPC分类号： C01C3/12 , B82Y30/00 , C01P2002/54 , C01P2004/64 , C01P2006/42
摘要： Gadolinium+3 (Gd3+) containing (or incorporated) Prussian blue lattice contrast agents that can be used as an MRI contrast agent have unexpectedly improved r1 relaxivities of 1 or 2 magnitudes higher than the commercial Gd3+-chelates as well as exceedingly, non-toxic, low release of the Gd3+ ions into an aqueous environment at a pH of about 2 to about 7.5. The Prussian blue lattice containing Gd3+ ions therein can be used for clinical diagnosis intravenously to human beings for medical imaging. The particle sizes of the doped Prussian blue lattices are of a nanosize scale and are very stable against agglomeration.
摘要翻译： 含有（或并入的）的钆+ 3（Gd3 +）可以用作MRI造影剂的普鲁士蓝色晶格造影剂意外地提高了比商业Gd3 +切片高1或2倍的r1松弛度，以及非常无毒的 ，在约2至约7.5的pH下将Gd 3+离子低释放到水性环境中。 其中含有Gd3 +离子的普鲁士蓝色晶格可用于静脉内给人类进行医学成像的临床诊断。 掺杂的普鲁士蓝色晶格的粒度是纳米尺度，并且对于聚集是非常稳定的。
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4.发明授权Gadolinium containing prussian blue nanoparticles as nontoxic MRI contrast agents having high relaxivity 有权含有普鲁士蓝色纳米粒子的钆，作为具有高弛豫性的无毒的MRI造影剂公开(公告)号：US08092783B2
公开(公告)日：2012-01-10
申请号：US12384391
申请日：2009-04-03
IPC分类号： A61B5/055
CPC分类号： C01C3/12 , B82Y30/00 , C01P2002/54 , C01P2004/64 , C01P2006/42
摘要： Gadolinium+3 (Gd3+) containing (or incorporated) Prussian blue lattice contrast agents that can be used as an MRI contrast agent have unexpectedly improved r1 relaxivities of 1 or 2 magnitudes higher than the commercial Gd3+-chelates as well as exceedingly, non-toxic, low release of the Gd3+ ions into an aqueous environment at a pH of about 2 to about 7.5. The Prussian blue lattice containing Gd3+ ions therein can be used for clinical diagnosis intravenously to human beings for medical imaging. The particle sizes of the doped Prussian blue lattices are of a nanosize scale and are very stable against agglomeration.
摘要翻译： 含有（或并入的）的钆+ 3（Gd3 +）可以用作MRI造影剂的普鲁士蓝色晶格造影剂意外地提高了比商业Gd3 +切片高1或2倍的r1松弛度，以及非常无毒的 ，在约2至约7.5的pH下将Gd 3+离子低释放到水性环境中。 其中含有Gd3 +离子的普鲁士蓝色晶格可用于静脉内给人类进行医学成像的临床诊断。 掺杂的普鲁士蓝色晶格的粒度是纳米尺度，并且对于聚集是非常稳定的。
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