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1.发明授权1-substituted-2-diphenylphosphinonaphthalene and transition metal complex comprising the same as a ligand 失效1-取代-2-二苯基膦基萘和与配体相同的过渡金属络合物
公开(公告)号：US5756760A
公开(公告)日：1998-05-26
申请号：US812549
申请日：1997-03-07
CPC分类号： C07F9/5721 , C07F15/0046 , C07F15/006 , C07F15/008 , Y02P20/55
摘要： A 1-substituted-2-diphenylphosphinonaphthalene represented by formula (I): ##STR1## wherein at least one of R.sup.1, R.sup.2, R.sup.3, and R.sup.4, which may be the same or different, represents a lower alkyl group having 1 to 4 carbon atoms which may be substituted with an alkoxy group, a phenyl group or --OR.sup.6 (wherein R.sup.6 represents a hydrogen atom, a lower alkyl group having 1 to 4 carbon atoms or an alcohol-protective group), and the rest of them represent a hydrogen atom; A represents a single bond or a methylene group; and R.sup.5 represents a substituted or unsubstituted phenyl group; and a transition metal complex comprising the 1-substituted-2-diphenylphosphinonaphthalene as a ligand. The transition metal complex is useful as a catalyst in asymmetric synthesis.
摘要翻译： 由式（I）表示的1-取代-2-二苯基膦基萘：其中R 1，R 2，R 3和R 4中至少有一个可以相同或不同，表示具有1 至4个可被烷氧基取代的碳原子，苯基或-OR 6（其中R6表示氢原子，碳原子数1〜4的低级烷基或醇保护基），其余的 表示氢原子; A表示单键或亚甲基; R5表示取代或未取代的苯基; 以及包含1-取代-2-二苯基膦基萘作为配体的过渡金属络合物。 过渡金属络合物可用作不对称合成中的催化剂。
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公开(公告)号：US6040465A
公开(公告)日：2000-03-21
申请号：US265371
申请日：1999-03-10
申请人： Sotaro Miyano , Tetsutaro Hattori , Osamu Uesugi , Yasufumi Tamai , Noboru Sayo
发明人： Sotaro Miyano , Tetsutaro Hattori , Osamu Uesugi , Yasufumi Tamai , Noboru Sayo
IPC分类号： B01J31/22 , C07D305/12 , B01J20/00
CPC分类号： C07D305/12
摘要： Disclosed is a process for producing an optically active .beta.-lactone represented by the general formula (I): ##STR1## wherein R.sup.1 represents an alkyl group having 1-9 carbon atoms which can be branched or a cycloalkyl group having 5-7 carbon atoms. The process comprises reacting an aldehyde represented by the general formula (II):R.sup.1 CHO (II)wherein R.sup.1 is the same as defined above, with a ketene represented by the general formula (III):CH.sub.2 .dbd.C.dbd.O (III)in the presence of a bissulfonamide/aluminum complex represented by the general formula (IV): ##STR2## wherein Ar represents 2,4,6-(R.sup.2).sub.3 C.sub.6 H.sub.2 (wherein R.sup.2 represents an alkyl group having 2-4 carbon atoms), Et represents an ethyl group and Ph represents a phenyl group.
摘要翻译： 公开了由通式（I）表示的光学活性β-内酯的制备方法：其中R1表示可以是支链或具有5-7个碳原子的环烷基的具有1-9个碳原子的烷基。 该方法包括使由通式（II）表示的醛：其中R 1与上述定义相同的R 1 CHO（II）与通式（III）表示的乙烯酮：CH 2 = C = O（III） 由通式（IV）表示的双磺酰胺/铝络合物的存在：其中Ar表示2,4,6-（R2）3C6H2（其中R2表示具有2-4个碳原子的烷基），Et表示乙基， Ph表示苯基。
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公开(公告)号：US5998635A
公开(公告)日：1999-12-07
申请号：US265694
申请日：1999-03-10
申请人： Sotaro Miyano , Tetsutaro Hattori , Yutaka Suzuki , Shuichi Oi , Takashi Miura , Tsutomu Hashimoto
发明人： Sotaro Miyano , Tetsutaro Hattori , Yutaka Suzuki , Shuichi Oi , Takashi Miura , Tsutomu Hashimoto
IPC分类号： C07D315/00 , C07D305/12
CPC分类号： C07D315/00
摘要： The present invention provides a process for producing a .beta.-lactone derivative by reacting an aldehyde represented by formula (1):RCHO (1)wherein R represents a C1-C15 alkyl group which may be substituted by an aryl group, a C2-C15 alkenyl group, a 5-7-membered alicyclic group, or a phenyl group which may be substituted by a C1-C4 alkyl group; and ketene in the presence of a transition metal-phosphine complex. An industrially valuable .beta.-lactone can be efficiently produced at high yield.
摘要翻译： 本发明提供了通过使由式（1）表示的醛：RCHO（1）反应制备β-内酯衍生物的方法，其中R表示可被芳基取代的C 1 -C 15烷基，C 2 -C 15 烯基，5-7元脂环基或可被C1-C4烷基取代的苯基; 和烯酮在过渡金属 - 膦配合物的存在下。 工业上有价值的β-内酯可以高产率有效生产。
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4.发明授权Optically active 1,1'-biphenanthryl-2,2'-diol, process for preparing the same, and resolving reagent comprising the same 失效光学活性1,1'-联蒽醌-2,2'-二醇，其制备方法和包含其的拆分试剂
公开(公告)号：US5849961A
公开(公告)日：1998-12-15
申请号：US812543
申请日：1997-03-07
CPC分类号： C07C39/12 , C07B57/00 , C07C2103/26
摘要： The novel optically active 1,1'-biphenanthryl-2,2'-diol is disclosed, which is obtained by preparing N((S)-1-phenylethyl)-1,1'-biphenanthryl-2,2'-diylthiophosphorylamide by using optically active phenylethylamine, recrystallizing the compound into an optically active compound, followed by reduction with a reducing agent. The diol compound according to the present invention is useful as a resolving reagent, a starting material of an optically active phosphine compound or a ligand in asymmetric synthesis, forming a complex with a transition metal or a rare earth element to provide a useful catalyst.
摘要翻译： 公开了通过制备N（（S）-1-苯基乙基）-1,1'-联苯-2,2'-二基硫代磷酰胺得到的新型光学活性1,1'-联蒽醌-2,2'-二醇 使用光学活性苯乙胺，将化合物重结晶为光学活性化合物，然后用还原剂还原。 根据本发明的二醇化合物可用作拆分试剂，光学活性膦化合物的原料或不对称合成中的配体，与过渡金属或稀土元素形成络合物以提供有用的催化剂。
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