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公开(公告)号:US5496564A
公开(公告)日:1996-03-05
申请号:US296403
申请日:1994-08-26
申请人: Sotoo Asakura , Yasuto Koyama , Youhei Kiyota , Kiyoko Akashi , Akira Kagayama , Yoshio Murakami , Toshiomi Nakate
发明人: Sotoo Asakura , Yasuto Koyama , Youhei Kiyota , Kiyoko Akashi , Akira Kagayama , Yoshio Murakami , Toshiomi Nakate
IPC分类号: A61K9/107 , A61K9/00 , A61K31/40 , A61K31/435 , A61K31/55 , A61K47/26 , A61P27/02 , A61P31/04 , A61P37/06 , C07D498/18 , A61K9/10 , A61K9/14 , A61K47/00
CPC分类号: A61K31/70 , A61K47/26 , A61K9/0048 , Y10S514/885 , Y10S514/912 , Y10S514/937 , Y10S514/951 , Y10S514/952 , Y10S514/97 , Y10S514/975
摘要: A suspendible composition comprising a tricyclic compound such as FK 506 substance which is 17-allyl-1,14-dihydroxy-12-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0.sup.4,9 ]octacos-18-ene-2,3,10,16-tetraone, or the like, and a pharmaceutically acceptable surfactant, which can be used as an orally administrable agent or eye drops and is useful for treating various diseases.
摘要翻译: 含有17-烯丙基-1,14-二羟基-12- [2-(4-羟基-3-甲氧基环己基)-1-甲基乙烯基] -23,25-二甲氧基 - 环己基的三环化合物如FK 506物质的悬浮组合物, 13,19,21,27-四甲基-11,28-二氧杂-4-氮杂三环[22.3.1.04,9]二十八烷-18-烯-2,3,10,16-四酮等,和药学上 可接受的表面活性剂,其可用作口服给药剂或滴眼剂,并且可用于治疗各种疾病。
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公开(公告)号:US5368865A
公开(公告)日:1994-11-29
申请号:US97617
申请日:1993-07-27
申请人: Sotoo Asakura , Yasuto Koyama , Youhei Kiyota , Kiyoko Akashi , Akira Kagayama , Yoshio Murakami , Toshiomi Nakate
发明人: Sotoo Asakura , Yasuto Koyama , Youhei Kiyota , Kiyoko Akashi , Akira Kagayama , Yoshio Murakami , Toshiomi Nakate
IPC分类号: A61K9/107 , A61K9/00 , A61K31/40 , A61K31/435 , A61K31/55 , A61K47/26 , A61P27/02 , A61P31/04 , A61P37/06 , C07D498/18 , A61K9/10 , A61K9/14
CPC分类号: A61K31/70 , A61K47/26 , A61K9/0048 , Y10S514/885 , Y10S514/912 , Y10S514/937 , Y10S514/951 , Y10S514/952 , Y10S514/97 , Y10S514/975
摘要: A suspendible composition comprising a tricyclic compound such as FK 506 substance which is 17-allyl-1,14-dihydroxy-12-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylviny1]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0.sup.4,9 ]octacos-18-ene-2,3,10,16-tetraone, or the like, and a pharmaceutically acceptable surfactant, which can be used as an orally administrable agent or eye drops and is useful for treating various diseases.
摘要翻译: 包含17-烯丙基-1,14-二羟基-12- [2-(4-羟基-3-甲氧基环己基)-1-甲基乙烯基] -23,25-二甲氧基 - 13,19,21,27-四甲基-11,28-二氧杂-4-氮杂三环[22.3.1.04,9]二十八-18-烯-2,3,10,16-四酮等,以及药学上可接受的 表面活性剂,其可以用作口服给药剂或滴眼剂,并且可用于治疗各种疾病。
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