摘要:
A suspendible composition comprising a tricyclic compound such as FK 506 substance which is 17-allyl-1,14-dihydroxy-12-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo-[22.3.1.0.sup.4,9 ]octacos-18-ene-2,3,10,16-tetraone, or the like, and a pharmaceutically acceptable surfactant, which can be used as an orally administrable agent or eye drops and is useful for treating various diseases.
摘要:
A suspendible composition comprising a tricyclic compound such as FK 506 substance which is 17-allyl-1,14-dihydroxy-12-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylviny1]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0.sup.4,9 ]octacos-18-ene-2,3,10,16-tetraone, or the like, and a pharmaceutically acceptable surfactant, which can be used as an orally administrable agent or eye drops and is useful for treating various diseases.
摘要:
The invention relates to a novel prodrug compound useful in the treatment of tumors, of the formula:A--CO(CH.sub.2).sub.m (NHCO).sub.n --RwhereinA is a residue of an antitumor substance having >NH or --NH.sub.2 group in the molecule,R is a residue of cholesterol,m is an integer of 1 or 2 andn is 0 or 1,and its salts.
摘要:
A fluid vessel which include a drug storing chamber, a capping member for hermetically sealing the mouth portion of the drug storing chamber, and a solvent chamber joined to the bottom of the drug storing chamber, wherein the drug storing chamber is provided with a communication hole at the bottom thereof for communicating with the solvent chamber and includes a protruding piece which hermetically seals the communication hole, protrudes into the drug storing chamber, and is movable so as to open the communication hole, while the capping member has an engaging portion to be engaged with the tip of the protruding piece whereby the protruding piece is moved to open the communication hole by rotation of the capping member. This vessel serves to simplify the manufacturing process and reduces the number of components, is readily disposed of, facilitates mixing the drug with the solvent, and is easy to store and handle in hospitals and other facilities.
摘要:
A lotion comprising a tricyclic compound, typically 17-allyl-1,14-dihydroxy-12-�2-(4-hydroxy-3-methoxycyclohexyl)-1-methylvinyl!-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo �22.3.1.0.sup.4,9 !octacos-18-ene-2,3,10,16-tetraone, or a pharmaceutically acceptable salt thereof, a solubilizing and/or absorption-promoting agent, a liquid medium, and optionally an emulsifier and/or a viscosity increasing agent. The lotion is stable, excellent in absorption and has less irritation against the skin and sustained release. Also, the lotion is effective for the treatment and/or prophylaxis of inflammatory and hyperproliferative skin diseases and cutaneous manifestations of immunologically-mediated illnesses.
摘要:
A sustained release medicinal preparation is produced by enclosing a macrocyclic compound represented by 17-allyl-1,14-dihydroxy-12-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylvinyl)-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0.sup.4,9 ]octacos-18-ene-2,3,10,16-tetraone or 17-ethyl-1,14-dihydroxy-12-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylvinyl]-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.0.sup.4,9 ]octacos-18-ene-2,3,10,16-tetraone, into the fine particles generally called microspheres which arc made of biodegradable polymer. This preparation, when, for example, given by injection, appreciably improves the transferance of said macrocyclic compound into the blood. Further, this is also used as an agent suitable for topical administration.
摘要:
Process for producing a hydrochloride of a vancomycin antibiotic, comprising subjecting an aqueous solution of a hydrochloride of a vancomycin antibiotic to a primary freezing at from −1° C. to −20° C. for a time sufficient to grow ice crystals, to form a primarily frozen substance, then subjecting said primarily frozen substance to a secondary freezing at from −25° C. to −80° C. to form a completely frozen solid, and then drying the resulting frozen solid in vacuo; and product obtained by the process.
摘要:
A fluid vessel including a drug vessel with a mouth portion sealed with a penetrable plug, a vial guide which holds the drug vessel and a flexible solvent vessel. The flexible solvent vessel has a drug solution outlet port and a communication port to the drug vessel, and an integrally molded tubular guide portion concentrically surrounding the communication port. Also included is a slidable communication mechanism housed in the tubular guide portion for communicating an inside of the solvent vessel and an inside of the drug vessel. Furthermore, also included is a cap for housing the vial guide and for rotatably sealing an opening of the guide portion, and a drug vessel push-down mechanism for moving the drug vessel down towards the communication port of the solvent vessel. The fluid vessel further includes a communication sequence control device for controlling a communication sequence so that, when the cap is rotated, the vial guide is moved down, without rotating, and the plug of the drug vessel is first pierced, and then a thin film of the communication port of the solvent vessel is pierced, thus communicating the drug vessel with the solvent vessel.
摘要:
A liposome preparation containing an immunosuppresive tricylic compound or a pharmaceutically acceptable salt thereof. Since the tricyclic compound is entrapped stably and quantitatively into the liposomes, a broad variety of drug forms and pharmaceutical preparations insuring a long duration of efficacy can be provided.
摘要:
The invention relates to a delayed action preparation which comprises a core comprising a drug and a swelling agent and an outer membrane comprising a biodegradable high molecular weight substance characterized in that the swelling agent is contained in a sufficient amount to cause a explosion of the outer membrane of biodegradable high molecular weight substance at a definite time after administration. This preparation provides for free control over the timing of drug release and is suited for administration not only by the oral route but also by the intramuscular, subcutaneous and other routes.