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公开(公告)号:US20230219958A1
公开(公告)日:2023-07-13
申请号:US18095429
申请日:2023-01-10
申请人: Southern Research Institute , UAB Research Foundation , The United States Government as represented by the Department of Veterans Affairs
发明人: Mark J. Suto , Bini Mathew , Corinne E. Augelli-Szafran , Marina Fosso Yatchang , Mohammad Athar , Anupam Agarwal , Ritesh Kumar Srivastava , Suhail Muzaffar , Jasim Khan
IPC分类号: C07D473/32 , A61P39/02
CPC分类号: C07D473/32 , A61P39/02
摘要: The present disclosure is concerned with purine diamine compounds for the treatment of conditions associated with BRD4, RIP3K, and/or IL6 signaling dysfunction such as, for example, cancer (e.g., lung cancer, skin cancer, bladder cancer, kidney cancer, liver cancer), arsenicosis, arsenic poisoning, inflammation, skin lesions, dysfunction of systemic organs, and skin blisters. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.