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公开(公告)号：US20250136706A1
公开(公告)日：2025-05-01
申请号：US18904965
申请日：2024-10-02
Applicant: Novartis AG , Emory University , The UAB Research Foundation
Inventor： Guido JUNGE , James RUSH , Andrew B. ADAMS , Alfred Joseph TECTOR, III
Abstract: The present invention relates to methods, treatment regimens, uses, kits and therapies for prevention of graft rejection in solid organ transplantation, particularly solid organ xenotransplantation, by administering an anti-CD40 antibody or a combination of an anti-CD40 antibody and an anti-C5 antibody.
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公开(公告)号：US20250134752A1
公开(公告)日：2025-05-01
申请号：US18836134
申请日：2023-03-03
Applicant: THE UAB RESEARCH FOUNDATION
Inventor： Timothy J. Gawne , Thomas T. Norton
Abstract: The present disclosure relates to techniques for anti-myopia visual display therapy using a simulated myopic blur. In one particular aspect, a method is provided that includes obtaining a pattern for a digital image, selecting a color channel of the digital image, applying a blur effect to the color channel that modifies the digital image to have a simulated blur, and providing anti-myopia visual display therapy to a subject using the modified digital image. The therapy comprises: (i) rendering the modified digital image on a display of a computing device within a visual environment of the subject, or (ii) placing the modified digital image within the visual environment of the subject, based on an optimal viewing time.
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公开(公告)号：US20250116036A1
公开(公告)日：2025-04-10
申请号：US18915925
申请日：2024-10-15
Applicant: THE UAB RESEARCH FOUNDATION
Inventor： Andrei V. Stanishevsky , Riley Yager , Courtney Severino
Abstract: An AC-electrospinning system and a method are provided for fabricating inorganic fiber tubular structures. The AC-electrospinning system preferably uses an electrode system that comprises an electrical charging component electrode and at least one of an AC field attenuating component and a precursor liquid attenuating component. Use of the AC-electrospinning process to fabricate the inorganic fiber tubular structures allows the structures to be made with high porosities that are not achievable using the conventional approach.
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公开(公告)号：US12271057B1
公开(公告)日：2025-04-08
申请号：US17129727
申请日：2020-12-21
Applicant: The UAB Research Foundation , Board of Trustees of the University of Albama, for and behalf of the University of Albama in Huntsville
Inventor： Patrick John Reardon , Timothy Jerner Gawne , Thomas Tolles Norton
Abstract: The present disclosure is directed to methods of tuning chromatic aberration of the eyes of a subject for the treatment of myopia. Refractive errors of an eye of the subject are assessed in the presence of one or more of red, blue, or green colored light, individually. A hybrid achromatic lens having a refractive portion and a diffractive portion is then designed, with the hybrid lens having a distribution of power varied between the refractive portion and diffractive portion. As such, the hybrid lens produces a state of chromatic aberration for the eyes of the subject capable of reducing or eliminating myopia advancement for the eyes of the subject.
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公开(公告)号：US20250101636A1
公开(公告)日：2025-03-27
申请号：US18906524
申请日：2024-10-04
Applicant: THE UAB RESEARCH FOUNDATION
Inventor： Andrei V. STANISHEVSKY , William Anthony BRAYER
IPC: D01D5/00
Abstract: An electrode system for use in an AC-electrospinning process comprises an electrical charging component electrode and at least one of an AC field attenuating component and a precursor liquid attenuating component. The electrical charging component electrode is electrically coupled to an AC source that places a predetermined AC voltage on the electrical charging component electrode. In cases in which the electrode system includes the AC field attenuating component, it attenuates the AC field generated by the electrical charging component electrode to better shape and control the direction of the fibrous flow. In cases in which the electrode system includes the precursor liquid attenuating component, it serves to increase fiber generation, even if the top surface of the liquid precursor is not ideally shaped or is below a rim or lip of the reservoir that contains the liquid on the electrical charging component electrode.
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Patent Agency Ranking
公开(公告)号：US20250090730A1
公开(公告)日：2025-03-20
申请号：US18726587
申请日：2023-01-03
Applicant: THE UAB RESEARCH FOUNDATION
Inventor： Vinoy Thomas , Jesse George Atherton Jones
Abstract: Various examples are provided related to blood-interface materials for metallic biomedical implants and devices. In one example, a bio-compatible implant or device includes an organosilane plasma polymerization (OPP) coating disposed on a surface of a metallic structure. The OPP coating can include inorganic silica disposed on bare metal of the metallic structure and forming a nano-textured surface. In another example, a biocompatible implant or device includes a composite coating disposed on a surface of the metallic structure. The composite coating can include silica-DEA, silica-MEA or silica-TEA coating disposed on bare metal of the metallic structure and forming a nano-textured surface. In another example, a method includes providing a metallic structure and exposing it to an OPP process to form a coating on the surface of the metallic structure to form the bio-compatible implant or device.
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公开(公告)号：USRE50320E1
公开(公告)日：2025-03-04
申请号：US17748682
申请日：2022-05-19
Applicant: UAB Research Foundation , ANJI PHARMACEUTICALS INC.
Inventor： Gattadahalli M. Anantharamaiah , Dennis Goldberg
IPC: A61K38/17 , A61K38/00 , A61P3/06 , A61P9/10 , C07K14/775
Abstract: Disclosed are synthetic apolipoprotein E-mimicking peptides, derivatives thereof, and related peptides, which are useful as therapeutic agents for reducing plasma cholesterol; synthetic methods of making the peptides; pharmaceutical compositions comprising the peptides, and methods of treating lipid and metabolic disorders using the disclosed synthetic apolipoprotein E-mimicking peptides and compositions thereof. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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8.发明授权公开(公告)号：US12233051B2
公开(公告)日：2025-02-25
申请号：US18352721
申请日：2023-07-14
Applicant: VANDERBILT UNIVERSITY , The UAB Research Foundation , The United States of America, as Represented by the Secretary, Department of Health and Human Services
Inventor： Matthew Hall , Daniel J. Urban , John Knight , Ross Holmes , Kyle David Wood , Alex Waterson , Victor M. Darley-Usmar , Leonard M. Neckers
IPC: A61K31/427 , A61K31/4439 , A61K31/506
Abstract: The disclosure provides methods of treating a patient having primary hyperoxaluria or idiopathic hyperoxaluria comprising administering a therapeutically effective amount of compound of the formula and pharmaceutically acceptable salts, solvates, and hydrates thereof to the patient. The variables, e.g. ring A, n, R, R3, R10, X, Y, and Z are defined herein. These compounds act as lactate dehydrogenase inhibitors and are useful inhibiting the conversion of glyoxylate to oxalate. When administered to a patient having a disease or disorder associated with elevated oxalate levels, such as PH type 1, type 2, or type 3 or idiopathic hyperoxaluria the compounds prevent or substantially reduce the amount and buildup of oxalate the patient's kidneys, bladder, urinary tract and other parts of the patient's body.
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公开(公告)号：US12215108B2
公开(公告)日：2025-02-04
申请号：US18095429
申请日：2023-01-10
Applicant: Southern Research Institute , UAB Research Foundation , The United States Government as represented by the Department of Veterans Affairs
Inventor： Mark J. Suto , Bini Mathew , Corinne E. Augelli-Szafran , Marina Fosso Yatchang , Mohammad Athar , Anupam Agarwal , Ritesh Kumar Srivastava , Suhail Muzaffar , Jasim Khan
IPC: C07D473/32 , A61P39/02
Abstract: The present disclosure is concerned with purine diamine compounds for the treatment of conditions associated with BRD4, RIP3K, and/or IL6 signaling dysfunction such as, for example, cancer (e.g., lung cancer, skin cancer, bladder cancer, kidney cancer, liver cancer), arsenicosis, arsenic poisoning, inflammation, skin lesions, dysfunction of systemic organs, and skin blisters. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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公开(公告)号：US20240417426A1
公开(公告)日：2024-12-19
申请号：US18672712
申请日：2024-05-23
Applicant: THE UAB RESEARCH FOUNDATION
Inventor： Dmitry Vassylyev , Norman Patrick Higgins , Marina Vassylyeva , Alexey Vasiliev
Abstract: Provided herein are compositions and methods for protein purification.
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