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    Spectroscopic methods to detect and characterize microorganisms
    6.
    发明授权
    Spectroscopic methods to detect and characterize microorganisms 有权

    公开(公告)号：US11105747B2

    公开(公告)日：2021-08-31

    申请号：US15925601

    申请日：2018-03-19

    Applicant: Spectral Platforms, Inc.

    Inventor： Ravi Verma ,  Changjun Yu

    IPC: G01N21/65 ,  C12Q1/04 ,  C12Q1/18 ,  G01N21/64 ,  C12Q1/14

    Abstract: Methods and systems for Resonant Raman spectroscopy are provided. Methods according to certain embodiments include irradiating a sample with a monochromatic light source at a first irradiation intensity and a second irradiation intensity, determining the intensity of one or more of the Resonant Raman scattering and fluorescence scattering at the first irradiation intensity and second irradiation intensity, calculating a rate of change of one or more of the intensity of Resonant Raman scattering and fluorescence in response to the change in irradiation intensity from the first irradiation intensity to the second irradiation intensity and comparing one or more of the rate of change in the intensity of Resonant Raman scattering and the rate of change in the intensity of fluorescence scattering with the rate of change in the irradiation intensity by the monochromatic light source to determine the Resonant Raman response of the sample. Methods also include determining the presence or absence of a microorganism in a sample and correcting for variations associated with measurement instrumentation (e.g., monochromatic light source) and variations associated with the sample (e.g., fluorescence from non-target compounds). Also provided are methods for determining the antimicrobial susceptibility of a microorganism to an antimicrobial agent as well as methods for characterizing a phenotype of an unknown microorganism in a sample. Systems for practicing the subject methods are also provided.

    ALBUMIN-BASED NON-COVALENT COMPLEXES AND METHODS OF USE THEREOF
    8.
    发明申请
    ALBUMIN-BASED NON-COVALENT COMPLEXES AND METHODS OF USE THEREOF 审中-公开
    基于ALBUMIN的非共价复合物及其使用方法

    公开(公告)号：US20160324933A1

    公开(公告)日：2016-11-10

    申请号：US15148587

    申请日：2016-05-06

    Applicant: Spectral Platforms, Inc.

    Inventor： Ravi Verma ,  Changjun Yu

    IPC: A61K38/38 ,  C12Q1/04 ,  A01N37/20

    CPC classification number: A61K38/385 ,  A01N43/90 ,  A61K9/00 ,  C12Q1/04 ,  A01N37/46

    Abstract: A non-covalent complex of an albumin molecule and a hydrophobic ligand, compositions containing the same, and methods of use thereof are provided. The present complex may find use in delivering the hydrophobic ligand to microorganisms that have albumin-binding outer surfaces, such as a cell wall.

    Abstract translation: 提供白蛋白分子和疏水性配体的非共价复合物，含有它们的组合物及其使用方法。 本发明的复合物可用于将疏水配体递送至具有白蛋白结合外表面的微生物，例如细胞壁。

    SPECTROSCOPIC METHODS, REAGENTS AND SYSTEMS TO DETECT, IDENTIFY, AND CHARACTERIZE BACTERIA FOR ANTIMICROBIAL SUSCEPTIBLITY
    9.
    发明公开
    SPECTROSCOPIC METHODS, REAGENTS AND SYSTEMS TO DETECT, IDENTIFY, AND CHARACTERIZE BACTERIA FOR ANTIMICROBIAL SUSCEPTIBLITY 审中-公开

    公开(公告)号：US20240344104A1

    公开(公告)日：2024-10-17

    申请号：US18389382

    申请日：2023-11-14

    Applicant: Spectral Platforms, Inc.

    Inventor： Ravi Verma

    IPC: C12Q1/04 ,  C12Q1/18 ,  G01N21/31

    CPC classification number: C12Q1/04 ,  C12Q1/18 ,  G01N21/31

    Abstract: Provided are methods of separating an absorption spectrum into a Rayleigh scattering contribution and an absorption contribution. By performing such separations and removing the influence of Rayleigh scattering, the absorption of a sample can be more accurately measured. Provided are additional methods that involve separating an absorption spectrum into a Rayleigh scattering contribution and an absorption contribution: assessing whether or not a microorganism is present in a biological fluid, assessing the effect of a pharmaceutical drug on a microorganism, and treating a subject suspected of having an infection. Provided are systems and non-transitory computer readable storage media for separating an absorption spectrum into a Rayleigh scattering and an absorption contribution.

    SPECTROSCOPIC METHODS TO DETECT AND CHARACTERIZE MICROORGANISMS
    10.
    发明申请
    SPECTROSCOPIC METHODS TO DETECT AND CHARACTERIZE MICROORGANISMS 有权

    公开(公告)号：US20220113256A1

    公开(公告)日：2022-04-14

    申请号：US17381563

    申请日：2021-07-21

    Applicant: Spectral Platforms, Inc.

    Inventor： Ravi Verma ,  Changjun Yu

    IPC: G01N21/65 ,  C12Q1/04 ,  C12Q1/18 ,  G01N21/64 ,  C12Q1/14

    Abstract: Methods and systems for Resonant Raman spectroscopy are provided. Methods according to certain embodiments include irradiating a sample with a monochromatic light source at a first irradiation intensity and a second irradiation intensity, determining the intensity of one or more of the Resonant Raman scattering and fluorescence scattering at the first irradiation intensity and second irradiation intensity, calculating a rate of change of one or more of the intensity of Resonant Raman scattering and fluorescence in response to the change in irradiation intensity from the first irradiation intensity to the second irradiation intensity and comparing one or more of the rate of change in the intensity of Resonant Raman scattering and the rate of change in the intensity of fluorescence scattering with the rate of change in the irradiation intensity by the monochromatic light source to determine the Resonant Raman response of the sample. Methods also include determining the presence or absence of a microorganism in a sample and correcting for variations associated with measurement instrumentation (e.g., monochromatic light source) and variations associated with the sample (e.g., fluorescence from non-target compounds). Also provided are methods for determining the antimicrobial susceptibility of a microorganism to an antimicrobial agent as well as methods for characterizing a phenotype of an unknown microorganism in a sample. Systems for practicing the subject methods are also provided.

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