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![ALKYNYL PYRROLO[2,3-d]PYRIMIDINES AND RELATED ANALOGS AS HSP90-INHIBITORS](/abs-image/US/2009/12/24/US20090318387A1/abs.jpg.150x150.jpg)
1.发明申请ALKYNYL PYRROLO[2,3-d]PYRIMIDINES AND RELATED ANALOGS AS HSP90-INHIBITORS 有权亚苄基吡咯并[2,3-d]嘧啶和相关模拟物作为HSP90-抑制剂公开(公告)号：US20090318387A1
公开(公告)日：2009-12-24
申请号：US12471298
申请日：2009-05-22
IPC分类号： A61K31/675 , A61K31/5377 , A61K31/519 , A61P35/00 , A61P35/02
CPC分类号： C07D487/02 , C07D487/04
摘要： Alkynyl pyrrolo[2,3-d]pyrimidines and related analogs are described and demonstrated to have utility as Heat Shock Protein 90 (HSP90) inhibiting agents used in the treatment and prevention of various HSP90 mediated disorders. Methods of synthesis and use of such compounds are also described and claimed.
摘要翻译： 描述和证明了炔基吡咯并[2,3-d]嘧啶和相关的类似物作为用于治疗和预防各种HSP90介导的病症的热休克蛋白90（HSP90）抑制剂。 还描述和要求保护这些化合物的合成和使用方法。
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![Alkynyl pyrrolo[2,3-d]pyrimidines and related analogs as HSP90-inhibitors](/abs-image/US/2012/01/10/US08093229B2/abs.jpg.150x150.jpg)
2.发明授权Alkynyl pyrrolo[2,3-d]pyrimidines and related analogs as HSP90-inhibitors 有权炔基吡咯并[2,3-d]嘧啶和相关类似物作为HSP90-抑制剂公开(公告)号：US08093229B2
公开(公告)日：2012-01-10
申请号：US12471298
申请日：2009-05-22
IPC分类号： A61K31/519 , A61K31/661 , A61P35/00 , C07F9/113 , C07D487/04
CPC分类号： C07D487/02 , C07D487/04
摘要： Alkynyl pyrrolo [2,3-d] pyrimidines of Formula I are described and demonstrated to have utility as Heat Shock Protein 90 (HSP90) inhibiting agents used in the treatment and prevention of various HSP90 mediated disorders. Methods of synthesis and use of such compounds are also described and claimed.
摘要翻译： 描述了式I的炔基吡咯并[2,3-d]嘧啶，并证明其可用作用于治疗和预防各种HSP90介导的病症的热休克蛋白90（HSP90）抑制剂。 还描述和要求保护这些化合物的合成和使用方法。
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公开(公告)号：US07241890B2
公开(公告)日：2007-07-10
申请号：US10494414
申请日：2002-10-30
申请人： Srinivas Rao Kasibhatla , Kevin Hong , Lin Zhang , Marco Antonio Biamonte , Marcus F. Boehm , Jiandong Shi , Junhua Fan
发明人： Srinivas Rao Kasibhatla , Kevin Hong , Lin Zhang , Marco Antonio Biamonte , Marcus F. Boehm , Jiandong Shi , Junhua Fan
IPC分类号： C07D473/40 , C07D473/24 , C07D473/34 , A61K31/52 , A61P35/00
CPC分类号： C07D473/00 , C07D473/16 , C07D473/24 , C07D473/34 , C07D473/40
摘要： Novel purine compounds of Formula I. and tautomers, pharmaceutically acceptable salts, and prodrugs thereof, wherein X is S, S(O), or S(O)2; and O is selected from alkyl, cycloalkyl, arylalkyl, aryl, heteroaryl, and heterocyclic, all optionally substituted, are described, as are pharmaceutical compositions comprising the same, complexes comprising the same, e.g., HSP90 complexes, and methods of using the same.
摘要翻译： 式I的新型嘌呤化合物及其互变异构体，其药学上可接受的盐和前药，其中X是S，S（O）或S（O）2。 以及O选自烷基，环烷基，芳基烷基，芳基，杂芳基和杂环，全部是任选取代的，以及包含其的药物组合物，包含其的复合物，例如HSP90复合物，及其使用方法。
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![Alkynyl pyrrolo[2,3-d]pyrimidines and related analogs as HSP90-inhibitors](/abs-image/US/2009/06/09/US07544672B2/abs.jpg.150x150.jpg)
4.发明授权Alkynyl pyrrolo[2,3-d]pyrimidines and related analogs as HSP90-inhibitors 有权炔基吡咯并[2,3-d]嘧啶和相关类似物作为HSP90-抑制剂公开(公告)号：US07544672B2
公开(公告)日：2009-06-09
申请号：US11277918
申请日：2006-03-29
IPC分类号： C07D487/04 , C07F9/38 , A61K31/519 , A61K31/662
CPC分类号： C07D487/02 , C07D487/04
摘要： Alkynyl pyrrolo[2,3-d]pyrimidines and related analogs are described and demonstrated to have utility as Heat Shock Protein 90 (HSP90) inhibiting agents used in the treatment and prevention of various HSP90 mediated disorders. Methods of synthesis and use of such compounds are also described and claimed.
摘要翻译： 描述和证明了炔基吡咯并[2,3-d]嘧啶和相关的类似物作为用于治疗和预防各种HSP90介导的病症的热休克蛋白90（HSP90）抑制剂。 还描述和要求保护这些化合物的合成和使用方法。
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公开(公告)号：US20080125446A1
公开(公告)日：2008-05-29
申请号：US11772496
申请日：2007-07-02
申请人： Srinivas Rao Kasibhatla , Kevin Hong , Lin Zhang , Marco Antonio Biamonte , Marcus F. Boehm , Jiandong Shi , Junhua Fan
发明人： Srinivas Rao Kasibhatla , Kevin Hong , Lin Zhang , Marco Antonio Biamonte , Marcus F. Boehm , Jiandong Shi , Junhua Fan
IPC分类号： A61K31/52 , C07D473/34 , C07K14/47 , C12N5/06
CPC分类号： C07D473/00 , C07D473/16 , C07D473/24 , C07D473/34 , C07D473/40
摘要： Novel purine compounds and tautomers and pharmaceutically acceptable salts thereof are described, as are pharmaceutical compositions comprising the same, complexes comprising the same, e.g., HSP90 complexes, and methods of using the same.
摘要翻译： 描述了新的嘌呤化合物和互变异构体及其药学上可接受的盐，以及包含其的药物组合物，包含其的复合物，例如HSP90复合物，及其使用方法。
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公开(公告)号：US07138402B2
公开(公告)日：2006-11-21
申请号：US10945851
申请日：2004-09-20
申请人： Srinivas R. Kasibhatla , Jiandong Shi , Jean-Yves Le Brazidec , Marco A. Biamonte , Kevin D. Hong , Marcus F. Boehm
发明人： Srinivas R. Kasibhatla , Jiandong Shi , Jean-Yves Le Brazidec , Marco A. Biamonte , Kevin D. Hong , Marcus F. Boehm
IPC分类号： C07D487/04 , A61K31/519 , A61P19/02 , A61P35/00 , A61P31/16
CPC分类号： C07D487/04 , C07D471/04 , C07D473/00
摘要： The present invention provides compounds represented by Formula I. R0 is selected from hydrogen, halogen, lower alkyl, —SR8, —OR8, —CN, and —NHR8, R1 is halogen, or lower alkyl; R2 is —NHR8; R3 is selected from the group consisting of hydrogen, halogen, —SR8, —OR8, —CN, —C(O)R9, —C(O)OH, —NO2, —NR8R10, lower alkyl, lower alkenyl, lower alkynyl, lower perhaloalkyl, aryl, heteroaryl, alicyclic and heterocyclic, all optionally substituted, and R5 is aryl, heteroaryl, alicyclic, or heterocyclic:
摘要翻译： 本发明提供由式I表示的化合物。R 0选自氢，卤素，低级烷基，-SR 8，-OR 8， ，-CN和-NHR 8，R 1是卤素或低级烷基; R 2是-NHR 8; R 3选自氢，卤素，-SR 8，-OR 8，-CN，-C（O） R 9，-C（O）OH，-NO 2，-NR 8 R 10，低级烷基 ，低级烯基，低级炔基，低级全卤代烷基，芳基，杂芳基，脂环族和杂环基，全部被取代，R 5是芳基，杂芳基，脂环族或杂环基：
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公开(公告)号：US20110164876A1
公开(公告)日：2011-07-07
申请号：US12985934
申请日：2011-01-06
申请人： Junichiro FUJITA , Reinald Gerhardt , Fang Wang , Jiandong Shi
发明人： Junichiro FUJITA , Reinald Gerhardt , Fang Wang , Jiandong Shi
IPC分类号： H04J14/02
CPC分类号： H04Q11/0005 , H04J14/0204 , H04J14/021 , H04J14/0212 , H04J14/0217 , H04J14/0219 , H04Q2011/0009 , H04Q2011/0015 , H04Q2011/0016
摘要： An optical switch system for dropping a ROADM node is presented. The switch system includes an N×M structure having two layers. A first layer includes optical splitters, each splitter receiving a multiplexed input signal and outputting a first multiplexed output signal. A second layer includes switches receiving the first multiplexed output signals from the optical splitters and generating a second multiplexed output signal. The second multiplexed output signal is typically one of the first multiplexed output signals. An optional third layer, which includes optical filters, receives the second multiplexed output signal from the switches and produces a non-multiplexed, single-wavelength output signal.
摘要翻译： 提出了一种用于丢弃ROADM节点的光交换机系统。 开关系统包括具有两层的N×M结构。 第一层包括光分路器，每个分路器接收复用的输入信号并输出第一复用输出信号。 第二层包括接收来自光分路器的第一复用输出信号并产生第二复用输出信号的开关。 第二复用输出信号通常是第一复用输出信号之一。 包括滤光器的可选的第三层从开关接收第二多路复用输出信号，并产生非复用的单波长输出信号。
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公开(公告)号：US20100086301A1
公开(公告)日：2010-04-08
申请号：US12573063
申请日：2009-10-02
申请人： Junichiro FUJITA , Reinald Gerhardt , Fang Wang , Jiandong Shi
发明人： Junichiro FUJITA , Reinald Gerhardt , Fang Wang , Jiandong Shi
IPC分类号： H04J14/00
CPC分类号： H04Q11/0005 , H04J14/0204 , H04J14/021 , H04J14/0212 , H04J14/0217 , H04J14/0219 , H04Q2011/0009 , H04Q2011/0015 , H04Q2011/0016
摘要： An optical switch system for dropping a ROADM node is presented. The switch system includes an N×M structure having two layers. A first layer includes optical splitters, each splitter receiving a multiplexed input signal and outputting a first multiplexed output signal. A second layer includes switches receiving the first multiplexed output signals from the optical splitters and generating a second multiplexed output signal. The second multiplexed output signal is typically one of the first multiplexed output signals. An optional third layer, which includes optical filters, receives the second multiplexed output signal from the switches and produces a non-multiplexed, single-wavelength output signal.
摘要翻译： 提出了一种用于丢弃ROADM节点的光交换机系统。 开关系统包括具有两层的N×M结构。 第一层包括光分路器，每个分路器接收复用的输入信号并输出第一复用输出信号。 第二层包括接收来自光分路器的第一复用输出信号并产生第二复用输出信号的开关。 第二复用输出信号通常是第一复用输出信号之一。 包括滤光器的可选的第三层从开关接收第二多路复用输出信号，并产生非复用的单波长输出信号。
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公开(公告)号：US20070173483A1
公开(公告)日：2007-07-26
申请号：US11531218
申请日：2006-09-12
申请人： Srinivas Kasibhatla , Jiandong Shi , Jean-Yves Le Brazidec , Marco Biamonte , Kevin Hong , Marcus Boehm
发明人： Srinivas Kasibhatla , Jiandong Shi , Jean-Yves Le Brazidec , Marco Biamonte , Kevin Hong , Marcus Boehm
IPC分类号： A61K31/675 , A61K31/519 , C07F9/6512 , C07D487/02
CPC分类号： C07D487/04 , C07D471/04 , C07D473/00
摘要： Pyrrolopyrimidines and related analogs are described and demonstrated to have utility as Heat Shock Protein 90 (HSP90) inhibiting agents used in the treatment and prevention of various HSP90 mediated disorders, e.g., proliferative disorders. Methods of synthesis and use of such compounds are also described and claimed.
摘要翻译： 吡咯并嘧啶类和相关类似物被描述和证明可用作用于治疗和预防各种HSP90介导的病症例如增殖性疾病的热休克蛋白90（HSP90）抑制剂。 还描述和要求保护这些化合物的合成和使用方法。
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公开(公告)号：US09875119B2
公开(公告)日：2018-01-23
申请号：US14560416
申请日：2014-12-04
申请人： Johnson Wong , David Mosimann , Greg Golds , Jiandong Shi , Sebastien Foucault , Jonathan Heller
发明人： Johnson Wong , David Mosimann , Greg Golds , Jiandong Shi , Sebastien Foucault , Jonathan Heller
CPC分类号： G06F9/44521 , G06F9/44505
摘要： In an example embodiment, a bundle loader is run in response to a communication from an application. The communication may indicate that the plurality of bundles of components in the application is to be executed. The plurality of bundles may include at least one bundle having a component that depends on a dependency component in another of the plurality of bundles. A configuration file indicating a set of the plurality of bundles to load in the bundle loader is received. The bundle loader is operated to load a bundle manifest for each bundle in the set of the plurality of bundles to load. Then, for each of the bundles in the set of plurality of bundles to load, the bundle is activated if no unactivated dependency component exists for any component in the bundle.
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