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公开(公告)号：US20230159954A1
公开(公告)日：2023-05-25
申请号：US17912932
申请日：2021-03-25
摘要： A method and apparatus for improving transfection efficiency and/or an intra-cellular delivery process in one or more eukaryotic cells is provided. The method includes providing at least one naked agent suitable for transfection and/or intra-cellular delivery. Introducing the at least one naked agent to one or more eukaryotic cells to form a mixture or transfection mixture and allowing the mixture or transfection mixture to undergo a transfection process or intra-cellular delivery process to form one or more transfected or treated eukaryotic cells. The method includes directing pulsed electromagnetic signals provided at any or any combination of a pre-determined frequency, at a pre-determined pulse rate, or at a pre-determined power, at the at least one a naked agent at step (a) prior to creating the mixture or transfection mixture, at the mixture or transfection mixture in step (b), at the mixture or transfection mixture in step (c) and/or at the transfected or treated cell mixture after step (c).
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2.发明公开公开(公告)号：US20230151386A1
公开(公告)日：2023-05-18
申请号：US17912928
申请日：2021-03-25
CPC分类号： C12N15/85 , C12M35/02 , C12N2310/10 , C12N2529/00
摘要： A method and apparatus for improving transfection efficiency in eukaryotic cells including the steps of providing a transfection mixture including an agent associated with at least one amphiphilic construct suitable for transfection. Adding the transfection mixture to one or more eukaryotic cells to form a transfection complex and allowing the transfection complex to undergo a transfection process to form one or more transfected cells. The method also includes the step of directing pulsed electromagnetic signals provided at any or any combination of a pre-determined frequency, at a pre-determined pulse rate, or at a pre-determined power, at the transfection mixture at step (a) prior to creating the transfection complex, at the transfection complex in step (b), at the transfection complex in step (c) and/or at the transfected cell complex after step (c).
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