公开(公告)号：US20210188777A1

公开(公告)日：2021-06-24

申请号：US17192683

申请日：2021-03-04

申请人： St. Jude Children's Research Hospital

发明人： R. Kip Guy ,  P. Jake Slavish ,  William Robert Shadrick ,  Brandon M. Young ,  Vincent A. Boyd ,  Nagakumar Bharatham ,  Jeanine E. Price ,  Anang Shelat

IPC分类号： C07D215/42 ,  C07D215/44 ,  C07D215/46 ,  C07D401/10 ,  C07D401/12 ,  C07D405/10 ,  C07D405/12 ,  C07D409/10 ,  C07D413/12

摘要： In one aspect, compounds and compositions that modulate a bromodomain and methods of making and using same are disclosed. The disclosed compounds and compositions can be useful for disorders associated with inhibition of a bromodomain such as, for example, cancer. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

公开(公告)号：US20200079739A1

公开(公告)日：2020-03-12

申请号：US16468657

申请日：2017-12-12

申请人： St. Jude Children's Research Hospital

发明人： R. Kip Guy ,  P. Jake Slavish ,  William Robert Shadrick ,  Brandon M. Young ,  Vincent A. Boyd ,  Nagakumar Bharatham ,  Jeanine E. Price ,  Anang Shelat

IPC分类号： C07D215/42 ,  C07D215/44 ,  C07D405/12 ,  C07D401/12 ,  C07D413/12 ,  C07D401/10 ,  C07D405/10 ,  C07D409/10 ,  C07D215/46

摘要： In one aspect, compounds and compositions that modulate a bromodomain and methods of making and using same are disclosed. The disclosed compounds and compositions can be useful for disorders associated with inhibition of a bromodomain such as, for example, cancer. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

公开(公告)号：US11787768B2

公开(公告)日：2023-10-17

申请号：US17192683

申请日：2021-03-04

申请人： St. Jude Children's Research Hospital

发明人： R. Kip Guy ,  P Jake Slavish ,  William Robert Shadrick ,  Brandon M. Young ,  Vincent A. Boyd ,  Nagakumar Bharatham ,  Jeanine E. Price ,  Anang Shelat

IPC分类号： C07D215/42 ,  C07D215/44 ,  C07D215/46 ,  C07D401/10 ,  C07D401/12 ,  C07D405/10 ,  C07D405/12 ,  C07D409/10 ,  C07D413/12

CPC分类号： C07D215/42 ,  C07D215/44 ,  C07D215/46 ,  C07D401/10 ,  C07D401/12 ,  C07D405/10 ,  C07D405/12 ,  C07D409/10 ,  C07D413/12

摘要： In one aspect, compounds and compositions that modulate a bromodomain and methods of making and using same are disclosed. The disclosed compounds and compositions can be useful for disorders associated with inhibition of a bromodomain such as, for example, cancer. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

公开(公告)号：US11028051B2

公开(公告)日：2021-06-08

申请号：US16468657

申请日：2017-12-12

申请人： St. Jude Children's Research Hospital

发明人： R. Kip Guy ,  P. Jake Slavish ,  William Robert Shadrick ,  Brandon M. Young ,  Vincent A. Boyd ,  Nagakumar Bharatham ,  Jeanine E. Price ,  Anang Shelat

IPC分类号： C07D215/42 ,  C07D215/44 ,  C07D215/46 ,  C07D401/10 ,  C07D401/12 ,  C07D405/10 ,  C07D405/12 ,  C07D409/10 ,  C07D413/12

摘要： In one aspect, compounds and compositions that modulate a bromodomain and methods of making and using same are disclosed. The disclosed compounds and compositions can be useful for disorders associated with inhibition of a bromodomain such as, for example, cancer. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.