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1.发明授权Oximes for treatment of peripheral and central nervous system exposure to acetyl cholinesterase inhibitors 有权用于治疗外周和中枢神经系统暴露于乙酰胆碱酯酶抑制剂的肟公开(公告)号：US08653108B1
公开(公告)日：2014-02-18
申请号：US13474399
申请日：2012-05-17
申请人： Stanton F. McHardy , Richard M. Corbett , Donald M. Maxwell , Michael W. Tidwell , Bismarck Campos , Christopher J. Bemben
发明人： Stanton F. McHardy , Richard M. Corbett , Donald M. Maxwell , Michael W. Tidwell , Bismarck Campos , Christopher J. Bemben
IPC分类号： A01N43/40 , A61K31/445
CPC分类号： C07D213/64 , A61K31/44 , A61K31/4427 , A61K31/4439 , A61K31/445 , A61K31/4453 , A61K31/4468 , A61K31/4545 , A61K31/472 , A61K31/473 , A61K31/506 , A61K45/06 , C07C251/38 , C07D211/26 , C07D211/34 , C07D211/58 , C07D217/16 , C07D219/12 , C07D401/12
摘要： The present invention relates to non-charged oxime compounds which are acetyl cholinesterase (AChE) reactivators of inhibited AChE and which protect against organophosphate poisoning both peripherally and in the central nervous system. Also disclosed are pharmaceutical compositions and methods for preparing the reactivator compounds and associated intermediates.
摘要翻译： 本发明涉及不含电荷的肟化合物，它们是乙酰胆碱酯酶（AChE）的抑制性AChE的再激活剂，并且能够在周围和中枢神经系统中保护有机磷中毒。 还公开了用于制备再活化剂化合物和相关中间体的药物组合物和方法。
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公开(公告)号：US08772345B2
公开(公告)日：2014-07-08
申请号：US13197550
申请日：2011-08-03
申请人： Stanton F. McHardy , Richard M. Corbett , Donald M. Maxwell , Michael W. Tidwell , Bismarck Campos , Christopher J. Bemben
发明人： Stanton F. McHardy , Richard M. Corbett , Donald M. Maxwell , Michael W. Tidwell , Bismarck Campos , Christopher J. Bemben
CPC分类号： C07D251/38 , A61K31/15 , A61K31/16 , A61K31/44 , A61K31/445 , A61K31/4453 , A61K31/4468 , A61K31/4545 , A61K31/473 , A61K31/506 , A61K31/513 , A61K45/06 , C07C251/38 , C07D211/26 , C07D211/34 , C07D211/58 , C07D213/64 , C07D219/12 , C07D401/12
摘要： The present invention relates to non-charged oxime compounds which are acetyl cholinesterase (AChE) reactivators of inhibited AChE and which protect against organophosphate poisoning both peripherally and in the central nervous system. Also disclosed are pharmaceutical compositions and methods for preparing the reactivator compounds and associated intermediates.
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3.发明申请OXIMES FOR TREATMENT OF PERIPHERAL AND CENTRAL NERVOUS SYSTEM EXPOSURE TO ACETYL CHOLINESTERASE INHIBITORS 有权用于治疗外周血和中枢神经系统暴露于乙酰胆碱酯酶抑制剂的毒素公开(公告)号：US20140066421A1
公开(公告)日：2014-03-06
申请号：US13474399
申请日：2012-05-17
申请人： Stanton F. McHardy , Richard M. Corbett , Donald M. Maxwell , Michael W. Tidwell , Bismarck Campos , Christopher J. Bemben
发明人： Stanton F. McHardy , Richard M. Corbett , Donald M. Maxwell , Michael W. Tidwell , Bismarck Campos , Christopher J. Bemben
IPC分类号： C07D213/64 , A61K31/506 , A61K31/473 , A61K31/472 , A61K31/4545 , A61K31/4468 , A61K31/445 , A61K31/4439 , A61K31/44 , C07D219/12 , C07D217/16 , C07D401/12 , C07D211/34 , A61K45/06 , A61K31/4427
CPC分类号： C07D213/64 , A61K31/44 , A61K31/4427 , A61K31/4439 , A61K31/445 , A61K31/4453 , A61K31/4468 , A61K31/4545 , A61K31/472 , A61K31/473 , A61K31/506 , A61K45/06 , C07C251/38 , C07D211/26 , C07D211/34 , C07D211/58 , C07D217/16 , C07D219/12 , C07D401/12
摘要： The present invention relates to non-charged oxime compounds which are acetyl cholinesterase (AChE) reactivators of inhibited AChE and which protect against organophosphate poisoning both peripherally and in the central nervous system. Also disclosed are pharmaceutical compositions and methods for preparing the reactivator compounds and associated intermediates.
摘要翻译： 本发明涉及不含电荷的肟化合物，它们是乙酰胆碱酯酶（AChE）的抑制性AChE的再激活剂，并且能够在周围和中枢神经系统中保护有机磷中毒。 还公开了用于制备再活化剂化合物和相关中间体的药物组合物和方法。
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