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公开(公告)号：US20170340647A1
公开(公告)日：2017-11-30
申请号：US15528452
申请日：2015-11-15
Applicant: SteadyMed Ltd.
Inventor： Jonathan Rigby , Peter Noymer , Robert Zwolinski
IPC: A61K31/5575 , C07C39/17 , A61K9/00 , A61M5/142 , C07C405/00 , C07C59/72
CPC classification number: A61K31/5575 , A61K9/0019 , A61M5/14248 , C07C39/17 , C07C59/72 , C07C405/0075
Abstract: This invention provides for a unit dosage form of treprostinil at a dosage of between 0.1 mg/mL and 25 mg/mL in a sterile fluid composition formulated for subcutaneous or intravenous injection, which composition does not comprise an antimicrobial preservative. Selectively activatable patch-pump assemblies comprising a sealed prefilled drug-reservoir containing the unit dosage form is described as are methods for reducing pain at a site of subcutaneous or intravenous infusion of treprostinil in a subject in need thereof, and methods of reducing irritation, inflammation or a combination thereof at a site of subcutaneous or intravenous infusion of treprostinil in a subject in need thereof. The invention also provides a method of treating pulmonary hypertension, and methods for treating, or reducing the severity or reducing the pathogenesis of Pulmonary arterial hypertension (PAH) in a subject making use of the compositions as herein described.
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公开(公告)号：US10071209B2
公开(公告)日：2018-09-11
申请号：US14384131
申请日：2013-03-11
Applicant: SteadyMed Ltd.
Inventor： Ian Solomon , Jacob Rand , Jonathan Rigby
CPC classification number: A61M5/422 , A61M5/14248 , A61N1/0456 , A61N1/0476 , A61N1/0492 , A61N1/36021
Abstract: The present invention provides an infusion-patch comprising; a cannula; a base; at least one adhesive region in said base suitable for skin attachment; at least one skin-access area within said base; and at least one conduit in fluid connection with said at least one skin access area, wherein said at least one conduit in fluid connection with said at least one skin access area facilitates the transfer of an anesthetic substance within at least a first anesthetic-reservoir which may be removably attached and in fluid connection with said at least one contact area, promoting delivery of said anesthetic substance to said at least one skin-access areas, and wherein said anesthetic substance delivered to said skin-access areas may be at least partially replenished without removing said infusion-patch.
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Patent Agency Ranking
公开(公告)号：US20150045718A1
公开(公告)日：2015-02-12
申请号：US14384131
申请日：2013-03-11
Applicant: SteadyMed Ltd.
Inventor： Ian Shlomo , Jacob Rand , Jonathan Rigby
CPC classification number: A61M5/422 , A61M5/14248 , A61N1/0456 , A61N1/0476 , A61N1/0492 , A61N1/36021
Abstract: The present invention provides an infusion-patch comprising; a cannula; a base; at least one adhesive region in said base suitable for skin attachment; at least one skin-access area within said base; and at least one conduit in fluid connection with said at least one skin access area, wherein said at least one conduit in fluid connection with said at least one skin access area facilitates the transfer of an anesthetic substance within at least a first anesthetic-reservoir which may be removably attached and in fluid connection with said at least one contact area, promoting delivery of said anesthetic substance to said at least one skin-access areas, and wherein said anesthetic substance delivered to said skin-access areas may be at least partially replenished without removing said in fusion-patch.
Abstract translation: 本发明提供了一种灌注补片，其包括： 套管 一个基地 所述基底中的至少一个粘合剂区域适于皮肤附着; 所述基座内的至少一个皮肤接近区域; 以及至少一个与所述至少一个皮肤接近区域流体连接的导管，其中与所述至少一个皮肤接近区域流体连接的所述至少一个导管便于在至少第一麻醉容器内的麻醉物质的转移 可以可移除地附接并与所述至少一个接触区域流体连接，促进所述麻醉物质递送到所述至少一个皮肤接近区域，并且其中输送到所述皮肤接近区域的所述麻醉物质可以至少部分补充 没有在融合贴片中去除。
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公开(公告)号：US11318148B2
公开(公告)日：2022-05-03
申请号：US16828145
申请日：2020-03-24
Applicant: SteadyMed, Ltd.
Inventor： Jonathan Rigby , Peter Noymer , Robert Zwolinski
IPC: A61K31/5575 , A61K9/00 , A61M5/142 , C07C39/17 , C07C59/72 , C07C405/00
Abstract: Embodiments include a system including a sealed prefilled drug-reservoir. The drug-reservoir may include a unit dosage of treprostinil in a sterile fluid composition. The composition may not include an antimicrobial preservative. The treprostinil may be present at a dosage of between 0.1 mg/mL and 25 mg/mL. In addition, the treprostinil may be treprostinil sodium Furthermore, the composition may include sodium chloride. The composition may also include a sodium ion from sodium chloride in a concentration from 3000 to 4500 ppm. The composition may not include metacresol.
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公开(公告)号：US10912896B2
公开(公告)日：2021-02-09
申请号：US16126036
申请日：2018-09-10
Applicant: SteadyMed Ltd.
Inventor： Ian Solomon , Jacob Rand , Jonathan Rigby
Abstract: The present invention provides an infusion-patch comprising; a cannula; a base; at least one adhesive region in said base suitable for skin attachment; at least one skin-access area within said base; and at least one conduit in fluid connection with said at least one skin access area, wherein said at least one conduit in fluid connection with said at least one skin access area facilitates the transfer of an anesthetic substance within at least a first anesthetic-reservoir which may be removably attached and in fluid connection with said at least one contact area, promoting delivery of said anesthetic substance to said at least one skin-access areas, and wherein said anesthetic substance delivered to said skin-access areas may be at least partially replenished without removing said infusion-patch. Embodiments of the present invention include methods of administering a drug using the infusion-patch.
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公开(公告)号：US20200237780A1
公开(公告)日：2020-07-30
申请号：US16828145
申请日：2020-03-24
Applicant: SteadyMed, Ltd.
Inventor： Jonathan Rigby , Peter Noymer , Robert Zwolinski
IPC: A61K31/5575 , C07C405/00 , C07C59/72 , C07C39/17 , A61M5/142 , A61K9/00
Abstract: Embodiments include a system including a sealed prefilled drug-reservoir. The drug-reservoir may include a unit dosage of treprostinil in a sterile fluid composition. The composition may not include an antimicrobial preservative. The treprostinil may be present at a dosage of between 0.1 mg/mL and 25 mg/mL. In addition, the treprostinil may be treprostinil sodium Furthermore, the composition may include sodium chloride. The composition may also include a sodium ion from sodium chloride in a concentration from 3000 to 4500 ppm. The composition may not include metacresol.
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公开(公告)号：US20190001076A1
公开(公告)日：2019-01-03
申请号：US16126036
申请日：2018-09-10
Applicant: SteadyMed Ltd.
Inventor： Ian Solomon , Jacob Rand , Jonathan Rigby
Abstract: The present invention provides an infusion-patch comprising; a cannula; a base; at least one adhesive region in said base suitable for skin attachment; at least one skin-access area within said base; and at least one conduit in fluid connection with said at least one skin access area, wherein said at least one conduit in fluid connection with said at least one skin access area facilitates the transfer of an anesthetic substance within at least a first anesthetic-reservoir which may be removably attached and in fluid connection with said at least one contact area, promoting delivery of said anesthetic substance to said at least one skin-access areas, and wherein said anesthetic substance delivered to said skin-access areas may be at least partially replenished without removing said infusion-patch. Embodiments of the present invention include methods of administering a drug using the infusion-patch.
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